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Comparative Pain Research Laboratory

Contact Information

Phone: 919.513.6854
Fax: 919.513.6336
Email: cvm_cprl@ncsu.edu

Dr. B. Duncan X. Lascelles,
PI and Director
Email: duncan_lascelles@ncsu.edu

Comparative Pain Research Laboratory Logo

Publications and Presentations

Student showing poster in exhibition hall
Morika Williams presents the summer research that she and Amy Kirkpatrick worked on at the National Veterinary Scholars Symposium in Orlando August 2011

Peer-reviewed Research Publications

  1. Aguado D, Abreu MB, Benito J, García-Fernández J, Gómez de Segura IA. Ketamine and Remifentanil Interactions on the Sevoflurane Minimum Alveolar Concentration and Acute Opioid Tolerance in the Rat.  Anesth Analg. 2011 Jul 21.
  2. Freire M, Robertson I, Bondell HD, Brown J, Hash J, Pease AP, Lascelles BD. Radiographic evaluation of feline appendicular degenerative joint disease vs. Macroscopic appearance of articular cartilage. Vet Radiology Ultrasound, 2011;52(3):239-47.
  3. Benito J, Aguado D, Abreu MB, García-Fernández J, Gómez de Segura IA. Remifentanil and Cyclooxygenase Inhibitors Interactions in the Minimum Alveolar Concentration of Sevoflurane in the Rat. Br J Anaesth. 2010 Dec;105(6):810-7. Epub 2010 Sep 22.
  4. Zamprogno H, Hash J, Hulse D, Lascelles BDX. Elbow Denervation in Dogs: Development of a surgical procedure and pilot testing in vivo. Accepted for publication, The Veterinary Journal
  5. Zamprogno H, Hansen BD, Bondell HD, Thomson Sumrell A, Simpson W, Robertson I, Brown J, Pease A, Roe SC, Hardie E, Lascelles BDX. Item generation and design testing of a questionnaire to assess degenerative joint disease-associated pain in cats. American Journal of Veterinary Research, 2010 Dec;71(12):1417-24.
  6. Trumpatori B, Carter JE, Hash J, Davidson GS, Mathews KG, Roe SC, Lascelles BDX. Evaluation of a mid-humeral block of the radial, ulnar, musculocutaneous and median nerves for analgesia of the distal forelimb in the dog. Veterinary Surgery, 2010;39: 785–796 [July 29, Epub ahead of print]
  7. Aguado D, Benito J, Gómez de Segura IA. Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine-ketamine in combination with either morphine or fentanyl. Vet J. 2011 Jul;189(1):63-6. Epub 2010 Jul 1.
  8. Gilor C, Graves TK, Lascelles BDX, Thomson AE, Simpson W, Halpern DS. Sex, body weight and body condition affect serum fructosamine concentrations in non-diabetic cats. Vet Clin Pathol. 2010 Apr 14. [Epub ahead of print]
  9. Lascelles BDX, Thomson Sumrell A, Henry III JB, Brown J, Simpson W, Wheeler S, Hansen BD, Robertson I, Zamprogno H, Freire M, Pease A. Cross-sectional study evaluating the prevalence of radiographic degenerative joint disease in domesticated cats. Veterinary Surgery 2010;39: 535-44.
  10. Wooten J, Lascelles BDX, Cook V, Law M, Blikslager AT. Evaluation of the Relationship between Gastrointestinal Injury and Cyclooxygenase (COX) Expression in Clinically Normal Dogs. American Journal of Veterinary Research 2010;71(6):630-635.
  11. Freire M, Brown J, Robertson I, Pease A, Hash J, Hunter S, Thomson Sumrell A, Simpson W, Lascelles BDX. Meniscal mineralization in domestic cats. Veterinary Surgery 2010;39(5):545-552.
  12. Lascelles BDX, DePuy V, Thomson Sumrell A, Hansen B, Marcellin-Little D, Bauer JE. Pain relieving and activity-enhancing properties of a putative therapeutic diet for feline degenerative joint disease associated pain. Journal of Veterinary Internal Medicine 2010; 24(3):487-95.
  13. Lascelles BDX, Friere M, DePuy V, Roe S, Smith E, Marcellin-Little D. Evaluation of functional outcome following BFX total hip replacement system using a pressure sensitive walkway. Veterinary Surgery 2010;39:71-77.
  14. Lascelles BDX, King S, Roe S, Marcellin-Little DJ, Jones S. Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of Orthopedic Research 2009;27:1204-1208.
  15. Hardie EM, Lascelles BD, Meuten T, Davidson GS, Papich MG, Hansen BD. Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively. Vet J. 2010 Dec 9. [Epub ahead of print].
  16. Wooten J, Blikslager AT, Marks S, Law M, Graeber E, Lascelles BDX. Effect of non-steroidal anti-inflammatory drugs with varying cyclooxygenase (COX)-2 selectivity on COX protein and prostanoid concentrations in canine pyloric and duodenal mucosa. American Journal of Veterinary Research 2009;70:1243-1249.
  17. Robertson SA, Wegner K, Lascelles BDX. Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats. Journal of Feline Medicine and Surgery 2009;11:76-81 [Jul 31, Epub ahead of print]
  18. Benito-de-la-Víbora J, Lascelles BDX, García-Fernández P, Friere M, Gómez de Segura IA. Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat. Veterinary Anaesthesia and Analgesia 2008;35:501-510.
  19. Vince KJ, Lascelles BDX, Mathews KG, , Altier C, Roe SC. Evaluation of distal leg wraps for the prevention of bacterial strike-through in an ex vivo canine model. Veterinary Surgery 2008;37:406-411.
  20. Wooten JG, Blikslager AT, Ryan KA, Marks SL, Law M, Lascelles BDX. Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. American Journal of Veterinary Research 2008;69(4):457-464.
  21. Lascelles BDX, Gaynor J, Smith ES, Roe SC, Marcellin-Little DJ, Davidson G, Carr J. Evaluation of amantadine as part of a multimodal analgesic regimen for the alleviation of refractory osteoarthritis pain. Journal of Veterinary Internal Medicine 2008;22(1):53-59.
  22. Robertson SA, Wegner K, Lascelles BDX. (2008) Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats. Journal of Feline Medicine and Surgery 2008 Aug 3.
  23. Benito-de-la-Víbora J, Lascelles BDX, García-Fernández P, Freire, M, Gómez de Segura IA. (2008) Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat. Epub 19th June 2008, Veterinary Anaesthesia and Analgesia.
  24. Wooten JG, Blikslager AT, Ryan KA, Marks SL, Law M, Lascelles BDX. (2008) Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. American Journal of Veterinary Research 69 (4): 457-464
  25. Lascelles BDX, Gaynor J, Smith ES, Roe SC, Marcellin-Little DJ, Davidson G, Carr J. (2008) Evaluation of amantadine as part of a multimodal analgesic regimen for the alleviation of refractory osteoarthritis pain. Journal of Veterinary Internal Medicine 22(1): 53-59
  26. Reid J, Nolan AM, Hughes JML, Lascelles BDX, Pawson P, Scott EM. (2007) Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Animal Welfare 16(S): 97-104
  27. Lascelles BDX, Hansen BD, Thomson A, Pierce CC, Rowinski E, Smith ES. (2008) Evaluation of a digitally integrated accelerometer-based activity monitor for the measurement of activity. Veterinary Anaesthesia and Analgesia 35(2):173-183. Epub 2007 Oct 10.
  28. Lascelles BDX, Gaynor J, Smith ES, Roe SC, Marcellin-Little DJ, Davidson G, Carr J. Evaluation of amantadine as part of a multimodal analgesic regimen for the alleviation of refractory osteoarthritis pain. Journal of Veterinary Internal Medicine Sept 2007
  29. Jaeger GH, Marcellin-Little DJ, DePuy V, Lascelles BDX. (2007) Validity of, Goniometric Measurements in Cats. American Journal of Veterinary Research 68:822-826.
  30. Hansen B, Lascelles BDX, Keene BW, Adams A, Thomson A. (2007) Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs. American Journal of Veterinary Research 68(5):468-475
  31. B. Duncan X. Lascelles, Bernie D. Hansen, Simon Roe, Venita DePuy, Andrea Thomson, Courtney C. Pierce, Eric S. Smith, Elizabeth Rowinski. (2007) Evaluation of client specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. Journal of Veterinary Internal Medicine 21(3):410-416
  32. Lascelles BDX, Findley K, Correa M, Roe S. (2007)Kinetic evaluation in normal cats using a pressure sensing walkway. Veterinary Record 160(15):512-516
  33. Thomas TM, Marcellin-Little DJ, Roe SC, Lascelles BDX, Brosey BP. (2006) Comparison of measurements obtained by use of an electrogoniometer and a universal plastic goniometer for the assessment of joint motion in dogs. American Journal of Veterinary Research 67(12):1974-9
  34. Lascelles BDX, Roe SC, Smith E, Reynolds BS, Markham J, Bergh MS, Marcellin D, Budsberg SC. (2006) Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs. American Journal of Veterinary Research 67(2):277-82.
  35. Morrow WE, Meyer RE, Roberts J and Lascelles BDX. (2006) Financial and welfare implications of immediate euthanasia of casualty nursery pigs. Journal of Swine Health Production 14(1):25-34.
  36. Lascelles BDX, Dernell W, Correa MT, Lafferty M, Devitt C, Kuntz C, Straw R and Withrow S. (2005) Improved Survival Associated with Postoperative Wound Infection in Dogs Treated with Limb-salvage Surgery for Osteosarcoma. Annals of Surgical Oncology 12:1-11.
  37. KuKanich B, Lascelles BDX, Aman A, Mealey AL and Papich MG. (2005) Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs. American Journal of Veterinary Research 66:1968-1974.
  38. Robertson SA, Lascelles BDX, Taylor PM and Sear JW. (2005) PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration. Journal of Veterinary Pharmacology and Therapeutics 28:453-460.
  39. Lascelles BDX, Blikslager A, Fox S and Reece D.(2005) Evaluation of 29 cases of duodenal perforation in dogs receiving a selective COX-2 inhibitor. Journal of American Veterinary Medical Association 227:1112-1117.
  40. Kukanich B, Lascelles BDX, Papich M. (2005) Pharmacokinetics and Pharmacodynamics of Morphine in Dogs following Intravenous Infusion and Multiple Intravenous Doses. American Journal of Veterinary Research 28:371-376.
  41. KuKanich B, Lascelles BDX and Papich MG. (2005) Evaluation of a von Frey Device for Pharmacodynamic Modeling of Morphine in Dogs. American Journal of Veterinary Research 66: 1616-1622.
  42. Kukanich B, Lascelles BDX and Papich M. (2005) Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs. Journal of Veterinary Pharmacology and Therapeutics 28: 371-376.
  43. Jaeger GH, Wosar MA, Marcellin-Little DJ and Lascelles BDX.(2005) Hinged Transarticular External Fixation for Joint Stabilization in Dogs. Journal of the American Veterinary Medical Association 227:586-91.
  44. Williams VM, Lascelles BDX and Robson MC. (2005) Current attitudes to, and use of, perioperative analgesia in dogs and cats by New Zealand veterinarians. New Zealand Veterinary Journal 53(3), 193-202.
  45. Kukanich B, Lascelles BDX and Papich M. (2005) Validation of a high pressure liquid chromatography and florescence polarization immunoassay for the determination of methadone in canine plasma. Therapeutic Drug Monitoring 27: 389-392.
  46. Hardie EM, Roe SC, Martin FR. Radiographic evidence of degenerative joint disease in 100 geriatric cats (1994-1997). JAVMA. 2002; 220:628-632.
  47. Lee DD, Papich MG, Hardie EM. A comparison of intravenous and transdermal fentanyl pharmacokinetics in cats. American Journal of Veterinary Research 2000:61, 672-677.
  48. Kyles AE, Hardie EM, Hansen BD, Papich MG. Comparison of transdermal fentanyl and intramuscular oxymorphone on post-operative behaviour after ovariohysterectomy in dogs. Research in Veterinary Science 1998; 65:245–251.
  49. Hardie EM, Hansen BD, Carroll GS. Behavior after ovariohysterectomy in the dog: what's normal? Applied Animal Behavioral Science 1997; 51:111–128.
  50. Hansen B, Hardie EM, Carroll GS. Physiology after ovariohysterectomy in the dog: what's normal? Applied Animal Behavioral Science 1997; 51:101–109.

Review Articles

  1. Sparkes AH, Heiene R, Lascelles BD, Malik R, Sampietro LR, Robertson S, Scherk M, Taylor P. ISFM and AAFP consensus guidelines: long-term use of NSAIDs in cats. Journal of Feline Medicine and Surgery 2010;12(7):521-538. [Lascelles assisted with manuscript planning, researching and writing]
  2. Lascelles BDX, Robertson SA. Diagnosing and treating degenerative joint disease associated pain. (Invited Review) Journal of Feline Medicine and Surgery 2010;12:200-212.
  3. Robertson SA, Lascelles BDX. Long term pain in cats – conditions, diagnosis and management. (Invited Review) Journal of Feline Medicine and Surgery 2010;12:188-199. [Lascelles assisted with manuscript planning, researching and writing]
  4. Lascelles BDX. Post-operative analgesia in the dog: a comparison of morphine, buprenorphine and pentazocine. Invited Commentary, 50th Issue of Journal of Small Animal Practice, Journal of Small Animal Practice 2010;51 (supplement 1):46-48.
  5. Innes JF, Clayton J, Lascelles BDX. Systematic review of the safety and efficacy of long-term NSAID use in the treatment of canine osteoarthritis. Veterinary Record 2010;166:226-230. [Lascelles assisted with manuscript planning, researching and writing]
  6. Lascelles BDX. Feline degenerative joint disease. (Invited Review) Veterinary Surgery 2010;39:2-13.
  7. Davis KM, Hardie EM, Lascelles BDX, Hansen B. Feline fibrosarcoma: Perioperative management. Compendium of Continuing Education, December 2007;712-732. [Lascelles assisted with mentoring of primary author (resident), manuscript planning, researching and writing]
  8. Lascelles BDX, Court MH, Hardie EM, Robertson SA. Nonsteroidal anti-inflammatory drugs in cats: a review. Veterinary Anaesthesia and Analgesia 2007;34(4):228-250. Review.

Recent Research Presentations

  1. Freire M, Brown J, Robertson I, Pease A, Hash J, Hunter S, Thomson Sumrell A, Simpson W, Lascelles BDX. Meniscal mineralization in domestic cats. Oral presentation at ACVS Scientific Symposium, Seattle, WA, USA, October 22, 2010 
  2. Zamprogno H, Hash J, Hulse D, Lascelles BDX. Elbow Denervation in Dogs: Development of a surgical procedure and pilot testing in vivo. Oral presentation at ACVS Scientific Symposium, Seattle, WA, USA, October 23, 2010 
  3. Lascelles BDX, DePuy V, Thomson Summrell A, Hansen B, Marcellin-Little D, Biourge V, Bauer JE. Pain relieving and activity-enhancing properties of a putative therapeutic diet for feline degenerative joint disease associated pain. Oral presentation at ACVS Scientific Symposium, Seattle, WA, USA, October 22, 2010
  4. Zamprogno H, Hansen BD, Bondell HD, Thomson Sumrell A, Simpson W, Robertson I, Brown J, Pease A, Roe SC, Hardie E, Lascelles BDX. Development of a questionnaire to assess degenerative joint disease-associated pain in cats: Item generation and questionnaire format. Oral presentation at ACVS Scientific Symposium, Seattle, WA, USA, October 22, 2010 
  5. Wernham BGJ, Trumpatori B, Hash J, Lipsett J, Davidson G, Wackerow P, Thomson Sumrell A, Lascelles BDX. Dose Titration Of Meloxicam In Dogs With Osteoarthritis-Associated Pain and Mobility Impairment. Oral presentation at ACVS Scientific Symposium, Seattle, WA, USA, October 23, 2010 
  6. Womack M, Robertson I, Freire M, Lascelles BDX. Evaluation of radius and ulna length and their relation to elbow degenerative joint disease in cats. Oral presentation at ACVS Scientific Symposium, Washington DC, USA, October 9, 2009
  7. Schultz A, Thomson A, Lascelles BDX. Assessment of the mobility enhancing effects of glucosamine hydrochloride, chondroitin sulfate and avocado/soybean unsaponifiables in cats with painful degenerative joint disease. Oral presentation at NCSU College of Veterinary Medicine Annual Research Forum, Raleigh, NC, USA, March 12, 2010.

 

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