Dr. Anthony Blikslager, DVM, PhD, DACVS
Professor, Equine Surgery
Phone: 919.513.7725
Fax: 919.513.6717
Email: anthony_blikslager@ncsu.edu
Education
- PhD in Physiology (Gastroenterology), North Carolina State University, May 1997
- Doctor of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, May 1989
Specialty
Gastroenterology
Professional Experience & Qualifications
- Chair, Morris Animal Foundation Large Animal Scientific Advisory Board, 2007-2008
- Member, USDA National Research Initiative Review Panel, 2008
- Guest Editor, Special Edition on Colic, Equine Veterinary Journal, 2008
- Editorial Review Board, American Journal of Veterinary Research, 1999-2002; 2007-2010
- Editorial Review Board, Veterinary Surgery, 1995-1999
- Diplomate, American College of Veterinary Surgeons, 1995
- Resident, Large Animal Surgery, July 1990-July 1994, North Carolina State University, College of Veterinary Medicine, Raleigh, NC
- Intern, Equine Medicine and Surgery, June 1989-June 1990, University of Missouri, Equine Center, Columbia, MO
Research Area
Gastrointestinal Physiology, studying mechanisms responsible for maintenance and restoration of the intestinal barrier, with the ultimate objective of pharmacologically restoring the mucosal barrier in patients suffering from diseases associated with increased intestinal permeability. Restoring the intestinal barrier would be of particular significance in patients suffering from diseases such as intestinal ischemia/reperfusion injury and gastric ulcer disease because of the potential medical complications associated with these diseases.
Selected Publications
Original Research
Nighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT. Exp Cell Res. 2009;315:110-8.ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum.
Cook VL, Jones Shults J, McDowell MR, Campbell NB, Davis JL, Marshall JF, Blikslager AT. Am J Vet Res. 2009;70:1259-68. Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.
Wooten JG, Blikslager AT, Marks SL, Law JM, Graeber EC, Lascelles BD. Am J Vet Res. 2009 Oct;70(10):1243-9. Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs.
Cook VL, Meyer CT, Campbell NB, Blikslager AT. Am J Vet Res. 2009;70:992-1000. Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum.
Cook VL, Jones Shults J, McDowell M, Campbell NB, Davis JL, Blikslager AT. Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine. Equine Vet J 2008;40:353-7
Little D, Brown SA, Campbell NB, Moeser AJ, Davis JL, Blikslager AT. Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am J Vet Res 2007 Jun;68:614-24.
Moeser AJ, Nighot PK, Engelke KJ, Ueno R, Blikslager AT. Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol 2007;292:G647-56
Review Articles in Peer-reviewed Journals
Cook VL, Blikslager AT. Use of systemically administered lidocaine in horses with gastrointestinal tract disease. J Am Vet Med Assoc. 2008;232(:1144-8.
Blikslager AT. Life in the gut without oxygen: adaptive mechanisms and inflammatory bowel disease. Gastroenterology 2008;134:346-348
Blikslager AT. Equine colic: future prospects for an age-old problem. J Equine Vet Sc 2007;27:546-547
Blikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J. Restoration of barrier function in injured intestinal mucosa. Physiol Rev 2007;87:545-64.
Little D, Jones SL, Blikslager AT. Cyclooxygenase (COX) inhibitors and the intestine. J Vet Intern Med 2007;21:367-77.
Books and Book Chapters
Blikslager AT. Pathophysiology of gastrointestinal disease: obstruction and strangulation. In: White NA, Moore JN, Mair TS, Eds., The Equine Acute Abdomen, Teton New Media, Jackson WY, pp. 100-107.
Blikslager AT, Jones SL. Surgical disorders of the small intestine. In: Smith BP, Ed., Large Animal Internal Medicine, Mosby, St. Louis, 2009, pp. 732-737
Blikslager AT, Jones SL. Surgical disorders of the large intestine. In: Smith BP, Ed., Large Animal Internal Medicine, Mosby, St. Louis, 2009, pp. 750-755
Blikslager AT. Non-steroidal anti-inflammatory. In: Robinson NE, Sprayberry, KA Eds, Current Therapy in Equine Medicine, Saunders Elsevier, Philadelphia, 2008, pp. 7-10.
Blikslager AT. Cecal impaction. In: Robinson NE, Sprayberry, KA Eds, Current Therapy in Equine Medicine, Saunders Elsevier, Philadelphia, 2008, pp. 405-407.