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Dr. Brian Gilger, DVM, MS, Dipl. ACVO, Dipl. ABT

Education

Doctor of Veterinary Medicine, Ohio State University, 1987
Masters of Science, Ophthalmology, Auburn University, 1992

Dr Gilger is a native of Akron, Ohio and received his veterinary degree from Ohio State University in Columbus, Ohio. After a one year internship in New York City, Dr. Gilger worked in a general small animal practice in Atlanta, Georgia. Following a 3 year Ophthalmology residency at Auburn University in Alabama, Dr. Gilger returned to Ohio State University as an Assistant Professor of Ophthalmology In 1992. In October 1995, Dr. Gilger joined the faculty at NC State University. His clinical interests include intraocular surgery such as cataract surgery, dry eye treatment and equine ocular disorders. His main research interest is ocular immunology. Brian is married and has one daughter, Katherine, and enjoys running and training for marathons.

Clinical Specialty

Ophthalmology, including equine ocular disorders, uveitis, immune-mediated ocular disease, and intraocular surgery such as cataract surgery.

Professional Experience & Qualifications

Diplomate, American Board of Toxicology, 2008
Diplomate, American College of Veterinary Ophthalmologists, 1993

Professor of Ophthalmology, NC State University, 2003-present
Associate Professor, Ophthalmology, NC State University, 1995-2003
Assistant Professor, Ophthalmology, Ohio State University, 1992-1995
Residency in Ophthalmology, Auburn University, 1989-1992
Graduate Student in Ophthalmology, Auburn University, 1989-1992
Internship, The Animal Medical Center, New York, New York, 1987-1988

Research Interests and Expertise

Ocular immunology, inflammation, toxicology, pharmacology, sustained ocular drug delivery.

In the Comparative Ophthalmology Research Laboratory, we study the pathogenesis of ocular immunologic and inflammatory disorders and have developed innovative methods to treat these potentially blinding diseases. We have been especially interested in the study of ocular toxicology and pharmacology of several medications. We are particularly interested in the two main causes of blindness in horses in the southern United States, equine recurrent uveitis and fungal keratitis. We are also interested in studying these naturally-occurring diseases, since they are models of common human diseases. Recently, we have explored methods to deliver therapeutic levels of medications to the eye for extended periods of time using micro-implant technology.

Recent and Selected Peer-Reviewed Publications (out of 85)

Douglass L, Davis JL, Salmon JH, Yi NY, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. Vet Pharm Ther 2008;31(6):511-516

Gilger BC, Bentley E. A moment of SCIENCE…please! Vet Ophthalmol 2008;11(5):279 Editorial.

McMullen RM, Clode AB, Pandiri AR, Malarkey D, Michau TM, Gilger BC.  Epibulbar melanoma in a foal. Vet Ophthalmol 2008;11(1):44-50

Gilger BC, Salmon JH, Yi NY, Barden CA, Chandler HL, Wendt J, Colitz CMH. Role of Bacteria in Recurrent Uveitis in Eyes of Horses from Southeastern United States.  Am J Vet Res 2008;69(10):1329-1335.

Yi NY, Davis JL. Salmon JH, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal injection of triamcinolone in horses. Vet Ophthalmol  

Chu PHW, Chan HHL, Ng Y, Brown B, Siu AW, Gilger BC, Wong F. Porcine global-flash multifocal electroretinogram: possible mechanisms for the glaucomatous changes in luminance-modulated adaptation. Invest Ophthalmol Vis Sci 2007 (In Press).

Ng YF, Chan HHL, Chu PHW, Beale BA, Gilger BC, Wong F. Retinal Pharmacologically defined components of the normal porcine multifocal ERG. Doc Ophthalmol. 2007; Aug 25; [Epub ahead of print]PMID: 17721791

Strobel BW, Wilkie DA, Gilger BC.  Retinal detachment in horses: 40 cases. Veterinary Ophthalmology, 2007;10(6):380-385.

Ollivier FJ, Gilger BC, Barrie K, Kallberg ME, Plummer CE, O’Reilly S, Gelatt KN, Brooks DE. Proteinases of the cornea and preocular tear film. Veterinary Ophthalmology 2007;10(4):199–206

Lee S, Kim H, Wang NS, Bungay PM, Gilger BC, Yaun P, Kim J, Csaky KG, Robinson MR. A pharmacokinetic and safety evaluation of an episcleral cyclosporine implant for potential use in high-risk keratoplasty rejection. Invest Ophthalmol Vis Sci 2007;48(5):2023-2029.

Acton AE, Beale AB, Gilger BC, Stoskopf MK. Sustained release cyclosporine therapy for bilateral keratoconjunctivitis sicca in a red wolf (Canis Rufus). Journal of Zoo and Wildlife Medicine 2006:37(4): 562–564.

Beale AB, Salmon JB, Michau TM, Gilger BC. Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in dogs. Vet Ophthalmol 2006;9:355-340.

McMullen RJ, Gilger BC. Keratometry, biometry, and prediction of intraocular lens power in the equine eye. Vet Ophthalmol 2006;9:357-360.

Gilger BC, Salmon, Wilkie DA, Cruysberg LP, Kim J, Hayat M, Kim H, Kim S, Yaun P, Lee S, Harrington SM, Murray PR, Edelhauser HF, Csasky KG, Robinson MR. A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis. Invest Ophthalmol Vis Sci 2006:47:2596-2605

Clode AB, Davis JL, Salmon J, Michau TM, Gilger BC. Aqueous humor concentration of voriconazole after topical and oral administration in horses. Am J Vet Res 2006;67;296-301.

Gilger BC, Michau TM, Salmon J.  Immune-mediated keratitis in horses: 19 cases (1998–2004).  Vet Ophthalmology 2005; 8(4):233-239.

Gilger BC, Reeves, KA, Salmon J. Ocular parameters related to drug delivery in the canine and equine eye: aqueous and vitreous humor volume and scleral surface area and thickness. Vet Ophthalmol 2005, 8(4):265-270.

Stoppini R, Gilger BC, Malarkey DE, et al. Bilateral nodular lymphocytic conjunctivitis in a horse. Vet Ophthalmology  2005; 8(2): 129-134.

Kim H, Csaky KG, Gilger BC, et al. Preclinical evaluation of a novel episcleral cyclosporine implant for ocular graft-versus-host disease. Invest Ophthalmol Vis Sci 2005; 46(2): 655-662.

Davis JL, Gilger BC, Robinson MR. Novel approaches to ocular drug delivery. Curr Opin Mol Ther. 2004;6(2):195-205

Davis JL, Stewart T, Brazik E, Gilger BC. The effect of topical administration of atropine sulfate on the normal equine pupil: influence of age, breed and gender. Vet Ophthalmol 2003;6(4):329-32.

Recent Research Presentations and Abstracts

McMullen RJ,  Salmon JH, Davidson MG, Gilger BC. In vitro and in vivo evaluation of an equine intraocular lens implant. American College of Veterinary Ophthalmologists, Boston, MA, October 2008.

Yi NY, Salmon JH, Gilger BC. Quantitative differences in mRNA expression of toll-like receptor (TLR)-2, -4, and -9 in normal equine eyes and eyes with equine recurrent uveitis. American College of Veterinary Ophthalmologists, Boston, MA, October 2008.

Gilger BC, Burleson GR. Evaluation of tonometer and intraocular pressure variability in Dutch Belted rabbits. American College of Veterinary Ophthalmologists, Boston, MA, October 2008.

Velagaleti P, Gilger BC, Moore CP, Liu J, Lawson C. Ocular distribution and pharmacokinetics of LX214, a clear, micellar topical formulation of voclosporin, a novel calcineurin inhibitor, after single or multiple ocular administrations in rabbit. Association of Research in Vision and Ophthalmology Summer Meeting, Monterey, CA, July 30, 2008.

Gilger BC, Moore CP, Narfstrom K, Liu J, Lawson C,  Cacek T, Anglade E, Velagaleti P. Preclinical Acute Toxicity and Pharmacokinetics of Episcleral LX201 Implants in Rabbits. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting, Ft Lauderdale, FL, May 2008.

Salmon JH, Douglass L, Yi NY, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2008.

McMullen RJ, Salmon JH, Davidson MG, Gilger BC. Refractive state of the enucleated equine eye after placement of a +30D intraocular lens.  Invest Ophthalmol Vis Sci. Abstract.  Association of Research in Vision and Ophthalmology Annual Meeting,  Ft Lauderdale, FL , May 2008.

Douglas L, Salmon JH, Yi NY, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal and subconjuctival injection of rapamycin (sirolimus) in horses. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Yi NY, Salmon JH, Gilger BC.  Ocular toxicity and pharmacokinetics of intravitreal injection of triamcinolone in horses. American College of Veterinary Ophthalmologists, Kona, Hawaii, October 2007.

Gilger BC, Salmon JH, Barden CA, Chandler HL, Wendt J, Colitz CMH. Bacteria in Eyes with Chronic Recurrent Uveitis from Southeastern United States. Annual Meeting of the ESVO – ECVO – ISVO – SOVI May 30 – June 3, Magazzini del Cotone, Genoa, Italy, May 2007.

Recent Books and Book Chapters

Books

Equine Ophthalmology, second edition. Edited by Brian C. Gilger, Published by Elsevier Science, In preparation. Expected publication date: September 2010.

Equine Ophthalmology, Edited by Brian C. Gilger, Published by Elsevier Science, February 25, 2005. 400 pages, 400 color photographs. http://www.us.elsevierhealth.com/product.jsp?isbn=0721605222

Book Chapters (selected from 40)

Gilger BC, Deeg CA.  Equine recurrent uveitis. Ed.: Gilger BC. Equine Ophthalmology Second Edition, Elsevier, Philadelphia. 2010 (in preparation). 

Gilger BC. Orbital disease. Ed.: Gilger BC. Equine Ophthalmology Second Edition, Elsevier, Philadelphia. 2010 (in preparation).

Gilger BC. Ophthalmic disorders. In, Wilson DA, Ed. Clinical Veterinary Advisor, The Horse.  Elsevier, 2008 In press (11 chapters).

Gilger BC.  Immunology of the ocular surface. In, Williams DA Ed, Veterinary Clinics of North America Small Animal. Elsevier, Phildelphia, 2008;38:223-231.

Gilger BC. Enucleation of the Equine Eye. In, Edward Robinson NE, Sprayberry KA, eds. Current Therapy in Equine Medicine 6th Edition.  In press.

Gilger BC. Equine Recurrent Uveitis. In, Edward Robinson NE, Sprayberry KA, eds. Current Therapy in Equine Medicine 6th Edition. In press.

Gilger BC.  Corneal diseases and surgery, In. Gelatt KN ed. Veterinary Ophthalmology 4th Edition. Philadelphia. Lippincott Williams & Wilkins. 2007

Links

• Comparative Ophthalmology Research Laboratory, Drs. Alison Clode and Brian Gilger, Principal Investigators
• About Equine Recurrent Uveitis
• American College of Veterinary Ophthalmologists
• Association in Research in Vision and Ophthalmology