Associate Professor of Radiology
Dr. Med. Vet: University of Bern, Switzerland
Diplomate, European College of Veterinary Diagnostic Imaging and American College of Veterinary Radiology
Phone (919) 513 6217
Use of imaging methods to investigate tumor perfusion in dogs and cats. Information about blood supply of a tumor is important for characterization of tumor type and selection of optimal treatment methods and response to treatment. Tumors with a low oxygen supply for example respond poorly to radiation therapy. Cancer research in dogs and cats is relevant to human patients as well as the spontaneous nature and the size of the patient closely resembles cancer in people. One method to investigate tumor perfusion non-invasively is contrast-enhanced ultrasound. Ultrasound contrast media are stabilized gas-filled microbubbles that are small enough to pass through capillaries. Their highly elastic shells are compressed or resonated when activated by an ultrasound beam, and they consequently produce a strong signal which can be registered by the ultrasound transducer. Vasculature and tissue perfusion of a tumor can thus be assessed repeatedly and non-invasively. Contrast-enhanced ultrasound has already been established as a safe imaging method in dogs and cats for assessment of various organs. It has been shown to accurately distinguish benign from malignant liver nodules in dogs. Furthermore, ultrasound contrast media can be used as a carrier for substances used for chemotherapy or gene therapy. Application of a strong ultrasound pulse in a specific location can burst the microbubbles and release the integrated substance in the target tissue.
- Seiler G, Ziemer L, Schultz S, Lee WMF, Sehgal CM. Dose Response Relationship of Ultrasound Contrast Agent In An In Vivo Murine Melanoma Model. Cancer Imaging 2007;7:216-223.
- Ivančić-Arndt M, Long F, Seiler G. Contrast Harmonic Ultrasound of Splenic Masses and Associated Liver Nodules in Dogs. J Am Vet Med Assoc 2009, 234: 88-94.
- Bagshaw H, Larenza M, Seiler G. A technique for ultrasound-guided paravertebral brachial plexus injections in dogs. Vet Radiol Ultrasound 2009, in press
- Kinns J, Aronson L, Hauptman J, Seiler G. Contrast enhanced ultrasound of the feline kidney. Vet Radiol Ultrasound 2009, in press