Dermatology - Autoimmune Clinic
Receiving Days: Monday (Dr. Olivry), appointments
Objectives
Dr. Olivry specializes in the diagnosis and treatment of small animal autoimmune skin diseases, especially pemphigus and other blistering diseases (bullous and mucous membrane pemphigoids, epidermolysis bullosa acquisita). Dr. Jackson has a special interest and expertise in cutaneous manifestations of lupus in small animals and autoimmune diseases of horses.
Our dermatology laboratory provides unique support to aid in the diagnosis of autoimmune diseases of animals, with the availability of direct and indirect immunofluorescence assays and identification of the antigen(s) targeted by circulating auto-antibodies. Currently, we investigate novel modalities for treatment of autoimmune skin diseases including oral glucocorticoid pulses, intravenous cyclophosphamide pulses, oral chlorambucil pulses and intravenous human immunoglobulins (on a limited basis).
English Bulldog with pemphigus foliaceus before (left) and after (right) immunosuppressive therapy
The presence of anti-basement membrane antibodies (green line) was revealed by indirect immunofluorescence in a dog with epidermolysis bullosa acquisita
In this dog with pemphigus foliaceus, the direct immunofluorescence method allowed to visualize auto-antibody deposition in the skin (fishnet-like green lines)