arosari

Mar 18, 2025

Cats with Hypertrophic Cardiomyopathy: The HALT HCM Study

Principle Investigator Sandra Tou Description This is a blinded, randomized, placebo-controlled clinical field study to provide substantial evidence of effectiveness of a disease modifying drug intervention in the management of ventricular hypertrophy in cats with subclinical Hypertrophic Cardiomyopathy (HCM). The study will consist of up to a 14-day screening period, followed by a 12-month once-weekly…

Mar 13, 2025

Now Recruiting Dogs with Acute Blindness Suspected to be Due to Optic Neuritis

Principle Investigator Dr Annie Oh Description Ophthalmology at NC State College of Veterinary Medicine is enrolling in a clinical study to measure VEPs (visual evoked potentials) and RNFL (retinal nerve fiber layer) thickness in dogs within 2 weeks of the onset of acute optic neuritis suspected to be caused by meningoencephalitis. The goal is to…

Feb 17, 2025

Effect of Iron Supplementation on the response to Varenzin-CA1 in Cats with CKD and Anemia

Principle Investigators Autumn N. Harris and Shelly Vaden Description Anemia is common in feline chronic kidney disease (CKD) and several options are available for treatment including the medication Varenzin CA-1 ® . Iron supplementation is an important part of the treatment of anemia in some patients with CKD and is given as standard of care…

Jan 6, 2025

Research Study for Senior Dogs: Targeting Frailty To Improve Healthspan and Well-Being

Description Over the past decade, there has been an increased interest in assessing frailty in our aging companion animals. The goal of this study is to monitor how frailty in senior dogs progresses over time, and how activity impacts their well-being. We hope to use what we learn to better care for our aging four…

Nov 21, 2024

A Blinded, Randomized, and Placebo-Controlled Clinical Trial of a Novel Veterinary Product for the Management of Chronic Kidney Disease in Cats

Principle Investigator Dr. Autumn Harris Description Evidence exists to suggest that aging of the kidney may contribute to the onset and progression of chronic kidney disease (CKD). Rapamycin is a drug that is a known modulator of the aging process and additionally may decrease the formation of fibrosis (scarring) in the kidney. A feline formulation…

Aug 28, 2024

Novel Biomarker and Therapeutic Target for CKD in Dogs

Principle Investigator Dr. Harris Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. Serum creatinine is currently used as a marker of kidney function, but it cannot detect early changes in kidney function. Detecting CKD early has significant importance because…

Jul 11, 2024

Dogs with Non-Seasonal Atopic Dermatitis

Principle Investigator Ina Herrmann Description This study is looking for dogs that have non-seasonal atopic dermatitis for a trial to investigate a novel injectable medication similar to Xolair®/Omalizumab with the potential to control the disease for weeks to months. The goal of this study is to reduce the need for daily medications and improving the…

Jul 8, 2024

Pulse Therapy with Clorazepate or Levetiracetam for Cluster Seizures

Principle Investigator Dr. Karen Munana Description We are seeking dogs with idiopathic epilepsy that experience cluster seizures for a new study led by Drs. Karen Muñana and Alejandra Mondino, evaluating pulse therapy for the in-home treatment of cluster seizures. This study is funded by the AKC-Canine Health Foundation. Dogs will be recruited based on the…

Jun 19, 2024

The Pathogenesis of Immune-Mediated Hemolytic Anemia (IMHA)

Principle Investigator Erika Gruber Description NC State University College of Veterinary Medicine is looking for IMHA patients for a blood sample study. The purpose of this project is to investigate whether a key pathway that inhibits phagocytosis (cell ingestion) contributes to IMHA pathogenesis. CD47 (“don’t eat me” signal) is a marker of “self” that negatively…

Apr 12, 2024

Now Recruiting Dogs with Babesia gibsoni

Principle Investigator Dr. Birkenheuer Description NC State College of Veterinary Medicine is enrolling dogs with Babesia gibsoni in a trial to evaluate if the use of a new drug combination (atovaquone/proguanil hydrochloride, azithromycin, and artemisinin) can improve treatment outcomes. A new treatment regimen using atovaquone/proguanil hydrochloride, azithromycin, and an artemisinin derivative has recently been shown…