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CANINE GASTROINTESTINAL PERMEABILITY ASSESSMENT USING COMMERCIALLY AVAILABLE LACTULOSE SOLUTION

Principle Investigator

Katie Tolbert

Description

We are looking for three types of patients to participate in our study investigating the development of an in-clinic readily available sugar solution to assess gastrointestinal barrier function and permeability.
  • Soft-Coated Wheaten Terriers (SCWT) healthy or diagnosed with protein-losing enteropathy.
  • Patients of any breed diagnosed with protein-losing enteropathy.
  • Healthy controls of any breed.

Testing Requirements

For Soft-Coated Wheaten Terriers (SCWT) and Protein-Losing Enteropathy (PLE) patients the study consists of one visit which includes the following:
  • PE
  • CBC
  • Chemistry
  • GI panel
  • Urinalysis
  • +/- UPC
  • Fecal float
  • Fecal occult blood
  • Alpha one proteinase fecal assay
  • Administration of an oral endoscopy camera
  • Administration of oral lactulose
For the healthy controls, the study will be divided into two appointments to allow time for the bloodwork to return.
During the second visit we will be administering an oral endoscopy camera that is the size of a large pill (patients need to be fasted for 16 hours prior to administering the camera).  We will then administer an oral lactulose solution and pull blood at specific intervals over one hour. Once the camera has been administered the patient will need to fast an additional 8 hours to allow time for the camera to pass through the GI tract. Owners will also be required to return the endoscopy camera.

Enrollment Start

06/01/2022

Enrollment Finish

06/01/2023

Eligibility

You dog is eligible to participate in this study if he/she:

  • weighs between 7 and 28kg (15.5 – 61.5lbs)
  • falls into one of these categories:
    1. a healthy SCWT
    2. a dog with a diagnosis of protein-losing enteropathy
    3. a healthy dog of any other breed (between 1.5 – 10yrs of age)

Flyer

VIEW

Contact

Jewels Darrow: 919-515-9130 OR cvmclinicalstudies@ncsu.edu