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Canine Spinal Cord Injury- Past Studies

February 12, 2018

Predictors of response to potassium channel blockade in chronically paralyzed dogs.

Predictors of response to potassium channel blockade in chronically paralyzed dogs. In a previous clinical trial, we showed that chronically paralyzed dogs have better stepping scores when treated with 4-aminopyridine, a drug that blocks potassium channels. However, we also reported that the response to this drug varied widely between individuals and the current study tried
February 12, 2018

The Effect of Post-Operative Rehabilitation on Recovery from Acute Thoracolumbar Intervertebral Disc Herniations

Recovery from spinal cord injury relies in part on the plasticity of the central nervous system. Plasticity is the ability of uninjured parts of the nervous system to take over the functions of parts that have been injured. This process can be enhanced by rehabilitation but the impact of rehabilitation programs in dogs recovering from
February 12, 2018

The effect of electromagnetic fields on postoperative pain and locomotor recovery in dogs with acute, severe thoracolumbar intervertebral disc extrusion: a randomized placebo-controlled, prospective clinical trial.

This study was sponsored by Assisi Animal Health. There is growing interest in the therapeutic potential of electromagnetic fields. Pulsed electromagnetic fields (PEMF) can have an effect at a cellular level, triggering pathways that result in reductions in inflammation and increases in growth factors. Human clinical trials show PEMF reduce pain following surgery and new
October 29, 2015

A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disc Herniation

Thirteen different centers participated in the trial across the US, and submitted their data to our research group. The dogs recruited had suffered the most severe grade of spinal cord injury due to...
October 29, 2015

Comparison of the effect of potassium channel antagonists and placebo on pelvic limb and bladder function in chronically paraparetic dogs – a blinded study funded by Neurometrix Inc

This project evaluated the effect of potassium channel blockade on stepping ability in dogs that were unable to walk. The premise for this study is that following severe spinal cord injury, some anatomically intact but...