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Center for Comparative Medicine and Translational Research

Research Core: Clinical Genomics

Concentrates on the genetic and epigenetic mechanisms in disease states, and in the identification analysis of spontaneous and induced (transgenic) familial and congenital disorders. Areas of focus include cellular genomic basis of familial disorders, the role of the epigenome in congenital/familial abnormalities, and functional genomics through microarrays, bioinformatics, biostatistics, transgenics and molecular therapeutics.

Specific areas of research include:

  • Cellular genomic approaches for the study and treatment of congenital and/or familial disorders
  • Development and implementation of gene expression profiling approaches to understand normal and abnormal biological processes
  • Linkage and mapping analysis for studying the genetic basis of inherited disorders
  • Epigenetic and imprinting disregulation effects on abnormal fetal and placental development
  • Development of transgenic animal models of human and animal disease
  • Development of statistical approaches for the utilization of animal models in clinical trials
  • Development of novel therapeutic approaches to genetic diseases

Core Leader

Dr. Natasha Olby