{"id":96,"date":"2026-09-18T17:58:29","date_gmt":"2026-09-18T17:58:29","guid":{"rendered":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/?page_id=96"},"modified":"2026-09-28T18:40:12","modified_gmt":"2026-09-28T18:40:12","slug":"neuroaging-and-olfaction","status":"publish","type":"page","link":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/publications\/neuroaging-and-olfaction\/","title":{"rendered":"Neuroaging and Olfaction"},"content":{"rendered":"\n\n\n\n
\n To read more about our research on neuroaging and olfaction in dogs, explore the articles and abstracts below\n <\/blockquote>\n\n\n
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NEuroAging<\/h2>\n <\/div>\n
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A Reliable and Holistic Approach to Evaluating Hearing and Cognitive Auditory Processing in Adult and Aged Companion Dogs<\/strong><\/h3>\n \n\n \n\t \t

Yang CC, Ruggeri M, Simon KE, Case B, Griffith EH, Gruen ME, Olby NJ. Sci Rep. 2026 Feb 10;16(1):8192. doi: 10.1038\/s41598-026-39648-4.<\/p>\n\t \t \n

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Aging is Modifiable: Current Perspectives on Healthy Aging in Companion Dogs and Cats<\/strong><\/h3>\n \n\n \n\t \t

Moniot D. Allaway D, Bermingham E, Dowgray N, Gruen ME, Hoummady S, McKenzie B, Olby NJ, Schoeman T. J Am Vet Med Assoc. 2025 Oct 1;264(2):234-241. doi: 10.2460\/javma.25.06.0412.<\/p>\n\t \t \n

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Quantifying Placebo and Trial Participation Effects on Cognitive Outcome Measures in Aging Dogs<\/strong><\/h3>\n \n\n \n\t \t

Simon KE, Russell K, Mondino A, Yang C, Case BC, Anderson Z, Whitley C, Griffith E, Gruen ME, Olby NJ. Geroscience. 2025 Dec;47(6):6909-6926. doi: 10.1007\/s11357-025-01822-3.\u00a0<\/p>\n\t \t \n

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Establishing a Clinically Applicable Frailty Phenotype Screening Tool for Aging Dogs<\/h3>\n \n\n \n\t \t

Russell K, Mondino A, Fefer G, Saker K, Gruen ME, Olby N. (2024) Front. Vet. Sci. 11:1335463.<\/p>\n\t \t \n

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Voxelwise Analysis of the Central Hearing Pathway in Senior Dogs Reveals Changes Associated with Fractional Lifespan<\/h3>\n \n\n \n\t \t

Yang C-C, Yap P-T, Wu Y, Zidan N, Fefer G, Nelson NC, Gruen ME, Olby NJ. (2024) Scientific Reports 14(18121).<\/p>\n\t \t \n

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A Randomized, Controlled Clinical Trial Demonstrates Improved Owner-Assessed Cognitive Function in Senior Dogs Receiving a Senolytic and NAD+ Precursor Combination<\/h3>\n \n\n \n\t \t

Simon KE, Russell K, Mondino A, Yang C, Case BC, Anderson Z, Whitley C, , Griffith E,
Gruen ME , Olby NJ . Sci Rep<\/em>\u00a014<\/strong>, 12399 (2024).<\/p>\n\t \t \n

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Cross-sectional and Longitudinal Analysis of Health-Related Quality of Life (HRQoL) in Senior and Geriatric Dogs<\/h3>\n \n\n \n\t \t

Mondino A, Yang C, Simon KE, Fefer G, Robertson J, Gruen ME, Olby NJ. (2024) \u00a0PLOS ONE 19(9): e0301181<\/p>\n\t \t \n

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Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs<\/h3>\n \n\n \n\t \t

Templeton GB, Fefer G, Case BC, Roach R, Azcarate MA, Gruen ME, Callahan BJ, Olby N. (2023) Animals\u00a013(24), 3846<\/p>\n\t \t \n

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Winning the Race with Aging: Age-Related Changes in Gait Speed and Its Association with Cognitive Performance in Dogs<\/h3>\n \n\n \n\t \t

Mondino A, Khan M, Case B, Fefer G, Panek WK, Gruen ME, Olby N. (2023) Front. Vet. Sci. 10:1150590.<\/p>\n\t \t \n

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Age-Associated Changes in Electroretinography Measures in Companion Dogs<\/h3>\n \n\n \n\t \t

Salzman MM, Merten N, Panek WK, Fefer G, Mondino A, Westermeyer HD, Gruen ME, Olby NJ, Mowat FM. (2023) Documenta Ophthalmologica, 147(1): 15-28.<\/p>\n\t \t \n

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Sleep and Cognition in Aging Dogs. A Polysomnographic Study<\/h3>\n \n\n \n\t \t

Mondino A, Catanzariti M, Mateos DM, Khan M, Ludwig C, Kis A, Gruen ME, Olby NJ. (2023) Front. Vet. Sci. 10:1151266.<\/p>\n\t \t \n

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A Novel Task of Canine Olfaction for Use in Adult and Senior Pet Dogs<\/h3>\n \n\n \n\t \t

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME.\u00a0Sci Rep<\/em>\u00a013<\/strong>, 2224 (2023).<\/p>\n\t \t \n

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Activity Patterns are Associated with Fractional Lifespan, Memory, and Gait Speed in Aged Dogs<\/h3>\n \n\n \n\t \t

Mondino A, Khan M, Case B, Giovagnoli S, Thomson A, Lascelles BDX, Gruen ME, Olby N. \u00a02023 Feb 14;13:2588.\u00a0Nature Scientific Reports<\/p>\n\t \t \n

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Development and Validation of a Sleep Questionnaire, SNoRE 3.0, to Evaluate Sleep in Companion Dogs<\/h3>\n \n\n \n\t \t

Mondino, A., Ludwig, C., Menchaca, C.\u00a0et al.<\/em>\u00a0Sci Rep 13<\/em>, 13340 (2023).<\/p>\n\t \t \n

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Activity Patterns are Associated with Fractional Lifespan, Memory, and Gait Speed in Aged Dogs<\/h3>\n \n\n \n\t \t

Mondino A, Khan M, Case B, Giovagnoli S, Thomson A, Lascelles BDX, Gruen ME, Olby N. (2023). Nature Scientific Reports<\/em>, 13<\/p>\n\t \t \n

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Relationship Between Engagement with the Impossible Task, Cognitive Testing, and Cognitive Questionnaires in a Population of Aging Dogs<\/h3>\n \n\n \n\t \t

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. (2023). Frontiers in Veterinary Science<\/em> <\/p>\n\t \t \n

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Use of Cognitive Testing, Questionnaires and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population<\/h3>\n \n\n \n\t \t

Fefer G, Panek WK, Khan MZ, Singer M, Westermeyer H, Mowat FM, Murdoch DM, Case B, Olby NJ*, Gruen ME*. (2022). Journal of Alzheimers Disease<\/em>, Jan. 2022:1367 \u2013 1378.<\/p>\n\t \t \n

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Relationship Between Hearing, Cognitive Function, and Quality of Life in Aging Companion Dogs<\/h3>\n \n\n \n\t \t

Fefer G, Khan MZ, Panek WK, Case B, Gruen ME*, Olby NJ*. (2022). Journal of Veterinary Internal Medicine<\/em>, 36 (5), 1708-1718.<\/p>\n\t \t \n

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Static Posturography as a Novel Measure of the Effects of Aging on Postural Control in Dogs<\/h3>\n \n\n \n\t \t

Mondino\u00a0A., Wagner\u00a0G., Russell\u00a0K., Lobaton\u00a0E., Griffith\u00a0E, Gruen, M., . . . Olby, N. J. (2022). PLoS ONE<\/em>,\u00a01<\/em>7(7), 1-20.<\/p>\n\t \t \n

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Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population<\/h3>\n \n\n \n\t \t

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., . . . Gruen, M. E. (2022). Journal of Alzheimer’s Disease, 87<\/em>(3), 1367-1378.<\/p>\n\t \t \n

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Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience<\/h3>\n \n\n \n\t \t

McKenzie, B. A., Chen, F. L., Gruen, M. E., & Olby, N. J. (2022). Frontiers in Veterinary Science, <\/em>9, 1-13.<\/p>\n\t \t \n

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Age-related Visual Decline in Companion Dogs: A Cross-sectional ERG Study in a Translational Model Species<\/h3>\n \n\n \n\t \t

Mowat, F. M., Panek, W. K., Fefer, G., Banghart, M., Wagner, G., Westermeyer, H. D., . . . Olby, N. (2021). Investigative Ophthalmology & Visual Science, 62<\/em>(8), 500.<\/p>\n\t \t \n

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Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs<\/h3>\n \n\n \n\t \t

Panek, W. K., Murdoch, D. M., Gruen, M. E., Mowat, F. M., Marek, R. D., & Olby, N. J. (2021). Molecular Neurobiology, 58<\/em>(2), 483-489.<\/p>\n\t \t \n

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Sustained Gaze is a Reliable In-home Test of Attention for Aging Pet Dogs<\/strong><\/h3>\n \n\n \n\t \t

Hoel, J. A., Templeton, G. B., Fefer, G., Case, B. C., Shah, A., Gruen, M. E., & Olby, N. J. (2021). <\/strong>Frontiers in Veterinary Science, 8<\/em>, 1-9.<\/p>\n\t \t \n

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Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs<\/h3>\n \n\n \n\t \t

Panek, W. K., Gruen, M. E., Murdoch, D. M., Marek, R. D., Statchel, A. F., Mowat, F. M., . . . Olby, N. J. (2020). Molecular Neurobiology, 57<\/em>(7), 3143-3149.<\/p>\n\t \t \n

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Olfaction<\/h2>\n <\/div>\n
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A Novel Test of Canine Olfaction for Use in Adult and Senior Pet Dogs<\/h3>\n \n\n \n\t \t

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. (2023). Nature Scientific Reports<\/em><\/p>\n\t \t \n

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Olfactory Discrimination and Generalization of Ammonium Nitrate and Structurally Related Odorants in Labrador Retrievers<\/strong><\/h3>\n \n\n \n\t \t

Lazarowski, L., Foster, M. L., Gruen, M. E., Sherman, B. L., Fish, R. E, Milgram, N. W., & Dorman, D. C. (2015).\u00a0Animal Cognition, 18<\/em>(6), 1255-1265.<\/p>\n\t \t \n

View Article<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span><\/p>\n <\/div>\n\n <\/a>\n<\/div>\n\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6858,"featured_media":0,"parent":28,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_dynamicHeaderBlockName":"ncst\/default-header","ncst_dynamicHeaderData":"{}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"class_list":["post-96","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/96","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/users\/6858"}],"replies":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/comments?post=96"}],"version-history":[{"count":5,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/96\/revisions"}],"predecessor-version":[{"id":176,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/96\/revisions\/176"}],"up":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/28"}],"wp:attachment":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/media?parent=96"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}