{"id":99,"date":"2026-09-18T18:17:14","date_gmt":"2026-09-18T18:17:14","guid":{"rendered":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/?page_id=99"},"modified":"2026-09-28T20:10:36","modified_gmt":"2026-09-28T20:10:36","slug":"pain-management","status":"publish","type":"page","link":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/publications\/pain-management\/","title":{"rendered":"Pain Management"},"content":{"rendered":"\n\n\n\n<blockquote class=\"wp-block-ncst-blockquote\">\n    <p>To read more about our research on pain management in dogs, explore the articles and abstracts below<\/p>\n  <\/blockquote>\n\n\n<div class=\"ncst-labeled-section wp-block-ncst-featured-content ncst-featured-content is-card-style layout-three-column\">\n  <div class=\"ncst-labeled-section__background\">\n    <div class=\"ncst-labeled-section__container\">\n             <div class=\"ncst-labeled-section__content\">\n        \n<div class=\"wp-block-ncst-featured-content\"><a\n    class=\"ncst-content-card wp-block-ncst-content-card with-image with-cta\"\n    href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40723489\/\"\n  >\n  \n          <div class=\"content-card__image-container\">\n        <div class=\"content-card__image-background\">\n          <img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"396\"\n            class=\"content-card__image wp-image-69\"\n            alt=\"canine clinical study participant smiles for the camera\"\n            src=\"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/Screenshot-2025-02-04-133839.png\"\n            style=\"aspect-ratio: 16\/9; object-fit: cover; \"\n srcset=\"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/Screenshot-2025-02-04-133839.png 720w, https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/Screenshot-2025-02-04-133839-300x165.png 300w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/>\n        <\/div>\n      <\/div>\n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Physical Activity Monitors in Companion Animal Chronic Pain Research-A Review Focused on Osteoarthritis Pain<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Thonen-Fleck C, Sharon KP, Enomoto M, LeBouef M, Roberts DL, Gruen ME, Lascelles<br>BDX. Animals (Basel). 2025 Jul 10;15(14):2025. doi: 10.3390\/ani15142025.\u00a0<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-image with-cta\"\n    href=\"https:\/\/www.frontiersin.org\/journals\/pain-research\/articles\/10.3389\/fpain.2025.1589082\/full\"\n  >\n  \n          <div class=\"content-card__image-container\">\n        <div class=\"content-card__image-background\">\n          <img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\"\n            class=\"content-card__image wp-image-158\"\n            alt=\"bull dog with its owner\"\n            src=\"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/NJL0112-CX-600x400-1.jpg\"\n            style=\"aspect-ratio: 16\/9; object-fit: cover; \"\n srcset=\"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/NJL0112-CX-600x400-1.jpg 600w, https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/NJL0112-CX-600x400-1-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/>\n        <\/div>\n      <\/div>\n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Tailoring treatment: dog breed status influences pain assessment and treatment in emergency veterinary care<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Caddiell RMP,\u00a0White PA, McNamee EH, Lynch AM, Lascelles BDX, Gruen ME. Front. Pain Res. 6:1589082.<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-image with-cta\"\n    href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40177669\/\"\n  >\n  \n          <div class=\"content-card__image-container\">\n        <div class=\"content-card__image-background\">\n          <img loading=\"lazy\" decoding=\"async\" width=\"646\" height=\"412\"\n            class=\"content-card__image wp-image-178\"\n            alt=\"pet in waiting room\"\n            src=\"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/Screenshot-2026-05-20-at-2.19.46-PM.png\"\n            style=\"aspect-ratio: 16\/9; object-fit: cover; \"\n srcset=\"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/Screenshot-2026-05-20-at-2.19.46-PM.png 646w, https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-content\/uploads\/sites\/565\/2026\/09\/Screenshot-2026-05-20-at-2.19.46-PM-300x191.png 300w\" sizes=\"auto, (max-width: 646px) 100vw, 646px\" \/>\n        <\/div>\n      <\/div>\n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Factors Influencing, and Associated with, Physical Activity Patterns in Dogs with Osteoarthritis-Associated Pain<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Stevens C, Kawecki-Wright E, Rowlison de Ortiz A, Thomson A, Aker S, Perry E, Haupt E, Mondino A, Enomoto M, Gruen ME , Lascelles BDX. (2025) Front Vet Sci. 2025 Mar 19;12:1503009<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.nature.com\/articles\/s41598-023-40671-y\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Veterinary Education and Experience Shape Beliefs About Dog Breeds. Part 1: Pain Sensitivity<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">\u00a0Caddiell RMP, White P, Lascelles BDX, Royal K, Ange van-Heugten, Gruen ME. <em><em>Sci Rep<\/em> 13, 13846 (2023).<\/em><\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.nature.com\/articles\/s41598-023-40464-3\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Veterinary Education and Experience Shape Beliefs About Dog Breeds. Part 2: Trust<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Caddiell RMP, White P, Lascelles BDX, Royal K, Ange van-Heugten, Gruen ME.\u00a0<em><em>Sci Rep 13<\/em>, 13847 (2023)<\/em><\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2023.1165340\/full\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Pain Sensitivity Differs Between Dog Breeds But Not in the Way Veterinarians Believe<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Caddiell RMP, Cunningham RM, White P, Lascelles BDX*, Gruen ME. (2023). <em>Frontiers in Pain Research<\/em>, <em>4<\/em>. <br><\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.aaha.org\/globalassets\/02-guidelines\/2022-pain-management\/resources\/2022-aaha-pain-management-guidelines-for-dog-and-cats_updated_060622.pdf\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">2022 AAHA Pain Management Guidelines for Dogs and Cats<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Gruen, M. E., Lascelles, B. D. X., Colleran, E., Gottlieb, A., Johnson, J., Lotsikas, P., . . . Wright, B. (2022).  <em>Journal of the American Animal Hospital Association<\/em>, <em>58<\/em>(2), 55-76. <\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34779443\/\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\"><strong>Assessment of Sensory Thresholds in Dogs Using Mechanical and Hot Thermal Quantitative Sensory Testing<\/strong><\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Cunningham, R. M., Park, R. M., Knazovicky, D., Lascelles, B. D. X., &amp; Gruen, M. E. (2021). <em>Journal of Visualized Experiments<\/em>, <em>176<\/em>(e62841), 1-17.<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7077843\/\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\"><strong>Do Dog Breeds Differ in Pain Sensitivity? Veterinarians and the Public Believe They Do<\/strong><\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Gruen, M. E., White, W., &amp; Hare, B. (2020). <em>PLoS ONE<\/em>,\u00a0<em>15<\/em>(3), 1-14.<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.nature.com\/articles\/s41598-019-50623-0\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\"><strong>Functional Linear Modeling of Activity Data Shows Analgesic-mediated Improved Sleep in Dogs with Spontaneous Osteoarthritis Pain<\/strong><\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Gruen, M. E., Samson, D. R., &amp; Lascelles, B. D. X. (2019). <em>Scientific Reports<\/em>, <em>9<\/em>(14192), 1-6.<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/html\/10.1055\/s-0038-1660882\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Replicate Effects and Test-Retest Reliability of Quantitative Sensory Threshold Testing in Dogs With and Without Chronic Pain<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Knazovixky, D., Helgeson, E. S., Case, B., Thomson, A., Gruen, M. E., Maixner, W., &amp; Lascelles, B. D. X. (2018). <em>Veterinary and Comparative Orthopaedics and Traumatology, 31<\/em>(S 01).<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1558787817300497\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\"><strong>The Use of Trazodone to Facilitate Calm Behavior After Elective Orthopedic Surgery in Dogs: Results and Lessons Learned from a Clinical Trial<\/strong><\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Gruen, M. E., Roe, S. C., Griffith, E. H., &amp; Sherman, B. L. (2017).<em> Journal of Veterinary Behavior, 22<\/em>, 41-45.<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4414248\/#:~:text=Results,to%20confinement%20tolerance%20and%20calmness.\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\"><strong>Use of Trazodone to Facilitate Postsurgical Confinement in Dogs<\/strong><\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Gruen, M. E., Roe, S. C., Griffish, E., Hamilton, A., &amp; Sherman, B. L. (2014). <em>Journal of the American Veterinary Medical Association, 245<\/em>(3), 296-301.<\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">View Article<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/drive.google.com\/file\/d\/16lOBD0vIqyrKjCHyJX-asqWbEExPBQsP\/view?usp=sharing\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Qualitative Exploration of the Hidden Curriculum in Communicating Dog Breed<br>Stereotypes During Veterinary Clinical Training<\/h3>\n              \n\n              \n\t      \t        <p class=\"content-card__teaser\">Caddiell, R. M. P., Gruen, M. E., Lascelles, B. D. X., &amp; Kedrowicz, A. A. (2024). <em>Journal of Veterinary Medical Education<\/em>. <\/p>\n\t      \t    \n              <p class=\"content-card__cta\"><span class=\"text\">Read more<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n<\/div>\n\n              <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6858,"featured_media":0,"parent":28,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_dynamicHeaderBlockName":"ncst\/default-header","ncst_dynamicHeaderData":"{}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"class_list":["post-99","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/99","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/users\/6858"}],"replies":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/comments?post=99"}],"version-history":[{"count":3,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/99\/revisions"}],"predecessor-version":[{"id":181,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/99\/revisions\/181"}],"up":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/pages\/28"}],"wp:attachment":[{"href":"https:\/\/cvm.ncsu.edu\/comparative-behavioral-research\/wp-json\/wp\/v2\/media?parent=99"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}