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Paula Cray, PhD

Department Head, Population Health and Pathobiology

Contact:

pjcray@ncsu.edu
Office: 919.513.6440

Dr. Paula J. Fedorka-Cray is currently the Head of the Population Health and Pathobiology Department at the College of Veterinary Medicine, North Carolina State University, Raleigh, NC where the mission of the Department is to recruit, train, inspire, and graduate Doctors of Veterinary Medicine of exemplary knowledge, skill, and character. Formerly the Research Leader of the USDA-ARS Bacterial Epidemiology and Antimicrobial Resistance Research Unit in Athens, GA, Dr. Fedorka-Cray spent over 23 years in the government studying the ecology, pathogenesis, and antimicrobial resistance of food borne pathogens. She is most proud of her work as the Director of the animal arm of the National Antimicrobial Resistance Monitoring System (NARMS) from its inception in 1996 through 2012 and the USDA VetNet program from 2004 through 2012. She holds a BS degree from the Pennsylvania State University, a MS degree from North Dakota State University (Bacteriology), a MAS degree from The Johns Hopkins University (Administration) and a PhD from the University of Nebraska Medical School (Veterinary Medical Sciences Interdisciplinary Area – Microbiology/Immunology). She has received 17 awards, over 200 invited presentations and authored or co-authored more than 180 peer reviewed publications.
Infectious Diseases
  • Related antimicrobial resistance genes detected in different bacterial species co-isolated from swine fecal samples.Frye, J.G., Lindsey, R.L., Meinersmann, R.J., Berrang, M.E., Jackson, C.R., Englen, M.D., Turpin, J.B., Fedorka-Cray, P.J. | Foodborne Pathogens and Disease.   8(6):663-679. 2011.
  • Characterization of multidrug-resistant Escherichia coli by antimicrobial resistance profiles, plasmid replicon typing and pulsed-field gel electrophoresis.Lindsey, R.L., Frye, J.G., Thitaram, S.N., Meinersmann, R.J., Fedorka-Cray, P.J., Englen, M.D. | Microbial Drug Resistance. 17(2):157-163. 2011.
  • Application of chlorine dioxide to lessen bacterial contamination during broiler defeathering.Berrang, M.E., Meinersmann, R.J., Cox, N.A., Fedorka-Cray, P.J. | Journal of Applied Poultry Research. 20(1):33-39. 2011.
  • Anatomical distribution and genetic relatedness of antimicrobial-resistant Escherichia coli from healthy companion animals.Davis, J.A., Jackson, C.R., Fedorka-Cray, P.J., Barrett, J.B., Brousse, J.H., Gustafson, J., Kucher, M. | Journal of Applied Microbiology. 110(2):597-604. 2011.
  • Clostridium difficile from healthy food animals: Optimized isolation and prevalence.Thitaram, S.N., Frank, J.F., Lyon, S.A., Siragusa, G.R., Bailey, J.S., Lombard, J.E., Haley, C.A., Wagner, B.A., Dargatz, D.A., Fedorka-Cray, P.J. | Journal of Food Protection. 74(1):130-133. 2011.
  • Prevalence, species distribution and antimicrobial resistance of enterococci isolated from US dairy cattle.Jackson, C.R., Lombard, J.E., Dargatz, D.A., Fedorka-Cray, P.J. | Letters in Applied Microbiology. 52(1):41-48. 2011.
  • Plasmid-mediated quinolone resistance among non-typhi Salmonella enteric isolates, USA.Sjölund-Karlsson, M., Howie, R., Rickert, R., Krueger, A., Tran, T.T., Zhao, S., Ball, T., Haro, J., Pecic, G., Joyce, K., Fedorka-Cray, P.J., Whichard, J.M., McDermott, P.F. | Emerging Infectious Diseases. 16(11):1789-1791. 2010.
  • Evaluation of two commercial real-time PCR assays for detecting Campylobacter in broiler carcass rinses.Englen, M.D., Berrang, M.E., Meinersmann, R.J., Fedorka-Cray, P.J. | Journal of Food Safety. 30(3):732-739. 2010.
  • Analysis of risk factors associated with Salmonella spp. Isolated from U.S. feedlot cattle.Green, A.L., Dargatz, D.A., Wagner, B.A., Fedorka-Cray, P.J., Ladely, S.R., Kopral, C.A. | Foodborne Pathogens and Disease. 7(7):825-833. 2010.
  • An oligonucleotide microarray to characterize multidrug resistant plasmids.Lindsey, R.L., Frye, J.G., Fedorka-Cray, P.J., Welch, T.J., Meinersmann, R.J. | Journal of Microbiological Methods. 81(2):96-100. 2010.
  • Mechanisms of antimicrobial resistance and genetic relatedness among enterococci isolated from dogs and cats in the United States.Jackson, C.R., Fedorka-Cray, P.J., Davis, D.A., Barrett, J.B., Brousse, J.H., Gustafson, J., Kucher, M. | Journal of Applied Microbiology. 108(6):2171-2179. 2010.
  • Comparison of neck skin excision and whole carcass rinse sampling methods for microbiological evaluation of broiler carcasses before and after immersion chilling.Cox, N.A., Richardson, L.J., Cason, J.A., Buhr, R.J., Vizzier-Thaxton, Y., Smith, D.P., Fedorka-Cray, P.J., Romanenghi, C.P., Pereira, L.V.B., Doyle, M.P. | Veterinary Record, 73(5):976-980. 2010.
  • Frye, J.G., Lindsey, R.L., Rondeau, G., Porwollik, S., Long, F., McClelland, M., Jackson, C.R., Englen, M.D., Meinersmann, R.J., Berrang, M.E., Davis, J.A., Barrett, J.B., Turpin, J.B., Thitaram, S.N., Fedorka-Cray, P.J.Frye, J.G., Lindsey, R.L., Rondeau, G., Porwollik, S., Long, F., McClelland, M., Jackson, C.R., Englen, M.D., Meinersmann, R.J., Berrang, M.E., Davis, J.A., Barrett, J.B., Turpin, J.B., Thitaram, S.N., Fedorka-Cray, P.J. | Microbial Drug Resistance. 16(1):9-19. 2010.
  • Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enteric serotype Enteritidis: Reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes.O’Regan, E., Quinn, T., Frye, J.G., Pagés, J.M., Porwollik, S., Fedorka-Cray, P.J., McClelland, M., Fanning, S. | Antimicrobial Agents and Chemotherapy. 54(1):367-374. 2010.
  • Antibiotic-resistant organisms in relationship to meat. In Encyclopedia of Meat Sciences,Fedorka-Cray, P.J. | second edition (ed. M. Dikeman), Elsevier Limited, Oxford, UK, accepted 11/2013, publication 8/2014. (Book Chapter)
  • Characterication of blacmy plasmids and their possible role in source attribution of Salmonella enterica serotype Typhimurium infections.Folster, J.P., Tolar, B., Pecic, G., Sheehan, D., Rickert, R., Hise, K., Zhao, S., Fedorka-Cray, P.J., McDermott, P., Whichard, J.M. | Foodborne Pathogens and Disease. doi: 10.1089/fpd.2013.1670. 2014.
  • Survival of naturally occurring Campylobacter in refrigerated and frozen rinsates from a broiler carcass- a research note. Cox, N.A., Richardson, L.J., Berrang, M.E., Rigsby, L.L., Buhr, R.J., Plumblee., J.R., Fedorka-Cray, P.J. | Journal of Food Safety. 34(1):76-78. 2014.
  • Sampling naturally contaminated broiler carcasses for Salmonella by three different methods.Cox., N.A., Buhr, R.J., Smith, R.J., Smith, D.P., Cason, J.A., Rigsby, L.L., Bourassa, D.V., Fedorka-Cray, P.J., Cosby, D.E. | Journal of Food Protection. doi: 10.4315/0362-028.JFP-13-320. 2014.
  • A Comparison of non-typhoidal Salmonella from humans and food animals using pulsed-field gel electrophoresis and antimicrobial susceptibility patterns.Sandt, C.H., Fedorka-Cray, P.J., Tewari, D., Ostroff, S., Joyce, K., M’ikanatha, N.M. | PLoS ONE 8(10): e77836. doi.1371/journal.pone.0077836. 2013.
  • Antimicrobial resistance genes in multidrug-resistant Salmonella enterica isolated from animals, retail meats, and humans in the United States and Canada.Glenn, L.M., Lindsey, R.L., Folster, J.P., Pecic, G., Boerlin, P., Gilmour, M.W., Harbottle, H., Zhao, S., McDermott, P.F., Fedorka-Cray, P.J., Frye, J.G. | Microbial Drug Resistance. 19(3):175-184. 2013.
  • Occurrence of beta-lactamase genes among non-typhi Salmonella enterica isolated from humans, food animals, and retail meats in the United States and Canada.Sjolund-Karlsson, M., Howie, R.L., Blickenstaff, K., Boerlin, P., Ball, T., Chalmers, G., Duval, B., Haro, J., Rickert, R., Zhao, S.,  Fedorka-Cray, P.J., Whichard, J.M. | Microbial Drug Resistance. 19(3):191-197. 2013.
  • Variations in preenrichment pH of poultry feed and feed ingredients after incubation periods up to 48 hours. Cox, N.A., Cason, J.A., Buhr, R.J., Richardson, K.E., Richardson, L.J., Rigsby, L.L., Fedorka-Cray, P.J. | Journal of Applied Poultry Research. 22(2):190-195. 2013.
  • Evidence for horizontal and vertical transmission in Campylobacter passage from hen to her progeny. Cox, N.A., Richardson, L.J., Maurer, J.J., Berrang, M.E., Fedorka-Cray, P.J., Buhr, R.J., Byrd, J.A., Lee, M.D., Hofacre, C.L., O’Kane, P.M., Lammerding, A.M., Clark, A.G., Thayer, S.G., Doyle, M.P. | Food Protection Trends. 75(10):1896-1902. 2012.
  • Comparison of dkgB-linked intergenic sequence ribotyping to DNA microarray hybridization for assigning serotype to Salmonella enterica. Guard, J., Sanchez-Ingunza, R., Morales, C., Stewart, T., Liljebjelke, K., VanKessel, J., Ingram, K., Jones, D., Jackson, C., Fedorka-Cray, P.J., Frye, J., Gast, R., Hinton, Jr., A. | FEMS Microbiology Letters. 337(1):61-72. 2012.
  • Epidemiology and genotypic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) of porcine origin.Molla, B., Byrne, M., Abley, M., Mathews, J., Jackson, C., Fedorka-Cray, P., Sreevatsan, S., Wang, P., Gebreyes, W. | Journal of Clinical Microbiology.  50(11):3687-3693. 2012.
  • Comparison of individual, pooled, and composite fecal sampling for detection of Salmonella on U.S. dairy operations.Lombard, J.E., Beam, A.L., Nifong, E.M., Fossler, C.P., Kopral, C.A., Dargatz, D.A., Wagner, B.A., Erdman, M.M., Fedorka-Cray, P.J. | Journal of Food Protection. 75(9):1562-1571. 2012.
  • Characterization of extended-spectrum cephalosporin-resistant Salmonella enterica serovar Heidelberg isolated from food animals, retail meats, and humans in the United States 2009.Folster, J.P., Pecic, G., Singh, A., Duval, B., Rickert, Ayers, S., Abbott, J., McGlinchey, B., Baurt-Turpin, J., Haro, J., Hise, K., Fedorka-Cray, P.J., Whichard, J., McDermott, P. | Food borne Pathogens and Disease. 9(7):638-645. 2012.
  • Salmonella prevalence and antimicrobial susceptibility from the National Animal Health Monitoring System swine 2000 and 2006 studies.Haley, C.A., Dargatz, D.A., Bush, E.J., Erdman, M.M., Fedorka-Cray, P.J. | Journal of Food Protection. 75(3):428-436. 2012.
  • Analysis of Campylobacter jejuni whole genome DNA microarrays: Significance of prophage and hypervariable regions for discriminating isolates.Pittenger, L.G., Frye, J.G., McNerney, V., Reeves, J., Haro, J., Fedorka-Cray, P.J., Harrison, M.A., Englen, M.D. | Foodborne Pathogens and Disease. 9(5):473-479. 2012.
  • Characterization of multi-drug resistant Salmonella enterica serovar Heidelberg from a ground turkey-associated outbreak in the United States, 2011.Folster, J.P., Pecic, G., Rickert, R., Taylor, J., Zhao, S., Fedorka-Cray, P.J., Whichard, J., McDermott, P. | Antimicrobial Agents and Chemotherapy. 56(6):3465-3466. 2012.
  • Antimicrobial susceptibility to azithromycin among Salmonella enterica isolates from the United States.Sjölund-Karlsson, M., Joyce, K., Blickenstaff, K., Ball, T., Haro, J., Medalla, F.M., Fedorka-Cray, P.J., Zhao, S., Crump, J.A., Whichard, J.M. | Antimicrobial Agents and Chemotherapy. 55(9):3985-3989. 2011.
  • Single nucleotide polymorphisms that differentiate two subpopulations of Salmonella Enteritidis within phage type.Guard, J., Morales, C.A., Fedorka-Cray, P.J., Gast, R.K. | BMC Research Notes. 4:Article 369. 2011.
  • Prevalence, distribution, and molecular characterization of Salmonella recovered from swine finishing herds and a slaughter facility in Santa Catarina, Brazil.Kich, J.D., Coldebella, A., Morés, N., Nogueira, M.G., Cardoso, M., Fratamico, P.M., Call, J.E., Fedorka-Cray, P.J., Luchansky, J.B. | International Journal of Food Microbiology. 151(3):307-313. 2011.
  • Microarray-based analysis of incA/C plasmid-associated genes from multidrug-resistant Salmonella enterica.Lindsey, R.L., Frye, J.G., Fedorka-Cray, P.J., Meinersmann, R.J. | Applied and Environmental Microbiology. 77(19):6991-6999. 2011.
  • Analysis of antimicrobial resistance genes detected in multidrug-resistant Salmonella enterica serovar Typhimurium isolated from food animals.Glenn, L.M., Lindsey, R.L., Frank, J.F., Meinersmann, R.J., Englen, M.D., Fedorka-Cray, P.J., Frye, J.G. | Microbial Drug Resistance. 17(3):407-418. 2011.
  • Anatomical distribution and genetic relatedness of antimicrobial-resistant Escherichia coli from healthy companion animals.Davis, J.A., Jackson, C.R., Fedorka-Cray, P.J., Barrett, J.B., Brousse, J.H., Gustafson, J., Kucher, M. | Journal of Applied Microbiology. 110(2):597-604. 2011.
  • Clostridium difficile from healthy food animals: Optimized isolation and prevalence.Thitaram, S.N., Frank, J.F., Lyon, S.A., Siragusa, G.R., Bailey, J.S., Lombard, J.E., Haley, C.A., Wagner, B.A., Dargatz, D.A., Fedorka-Cray, P.J. | Journal of Food Protection. 74(1):130-133. 2011.
  • Prevalence, species distribution and antimicrobial resistance of enterococci isolated from US dairy cattle.Jackson, C.R., Lombard, J.E., Dargatz, D.A., Fedorka-Cray, P.J. | Letters in Applied Microbiology. 52(1):41-48. 2011.
  • Plasmid-mediated quinolone resistance among non-typhi Salmonella enteric isolates, USA. | Emerging Infectious Diseases. 16(11):1789-1791. 2010.
  • Evaluation of two commercial real-time PCR assays for detecting Campylobacter in broiler carcass rinses.Englen, M.D., Berrang, M.E., Meinersmann, R.J., Fedorka-Cray, P.J. | Journal of Food Safety. 30(3):732-739. 2010.
  • Analysis of risk factors associated with Salmonella spp. Isolated from U.S. feedlot cattle.Green, A.L., Dargatz, D.A., Wagner, B.A., Fedorka-Cray, P.J., Ladely, S.R., Kopral, C.A. | Foodborne Pathogens and Disease. 7(7):825-833. 2010.
  • An oligonucleotide microarray to characterize multidrug resistant plasmids.Lindsey, R.L., Frye, J.G., Fedorka-Cray, P.J., Welch, T.J., Meinersmann, R.J. | Journal of Microbiological Methods. 81(2):96-100. 2010.
  • Mechanisms of antimicrobial resistance and genetic relatedness among enterococci isolated from dogs and cats in the United States.Jackson, C.R., Fedorka-Cray, P.J., Davis, D.A., Barrett, J.B., Brousse, J.H., Gustafson, J., Kucher, M. | Journal of Applied Microbiology. 108(6):2171-2179. 2010.
  • Comparison of neck skin excision and whole carcass rinse sampling methods for microbiological evaluation of broiler carcasses before and after immersion chilling.Cox, N.A., Richardson, L.J., Cason, J.A., Buhr, R.J., Vizzier-Thaxton, Y., Smith, D.P., Fedorka-Cray, P.J., Romanenghi, C.P., Pereira, L.V.B., Doyle, M.P. | Veterinary Record, 73(5):976-980. 2010.
  • Frye, J.G., Lindsey, R.L., Rondeau, G., Porwollik, S., Long, F., McClelland, M., Jackson, C.R., Englen, M.D., Meinersmann, R.J., Berrang, M.E., Davis, J.A., Barrett, J.B., Turpin, J.B., Thitaram, S.N., Fedorka-Cray, P.J.Frye, J.G., Lindsey, R.L., Rondeau, G., Porwollik, S., Long, F., McClelland, M., Jackson, C.R., Englen, M.D., Meinersmann, R.J., Berrang, M.E., Davis, J.A., Barrett, J.B., Turpin, J.B., Thitaram, S.N., Fedorka-Cray, P.J. | Microbial Drug Resistance. 16(1):9-19. 2010.
  • Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enteric serotype Enteritidis: Reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes. | Antimicrobial Agents and Chemotherapy. 54(1):367-374. 2010.
  • Antibiotic-resistant organisms in relationship to meat. In Encyclopedia of Meat Sciences,Fedorka-Cray, P.J. | second edition (ed. M. Dikeman), Elsevier Limited, Oxford, UK, accepted 11/2013, publication 8/2014. (Book Chapter)
  • Characterication of blacmy plasmids and their possible role in source attribution of Salmonella enterica serotype Typhimurium infections.Folster, J.P., Tolar, B., Pecic, G., Sheehan, D., Rickert, R., Hise, K., Zhao, S., Fedorka-Cray, P.J., McDermott, P., Whichard, J.M. | Foodborne Pathogens and Disease. doi: 10.1089/fpd.2013.1670. 2014.
  • Sampling naturally contaminated broiler carcasses for Salmonella by three different methods.Cox., N.A., Buhr, R.J., Smith, R.J., Smith, D.P., Cason, J.A., Rigsby, L.L., Bourassa, D.V., Fedorka-Cray, P.J., Cosby, D.E. | Journal of Food Protection. doi: 10.4315/0362-028.JFP-13-320. 2014.
  • A Comparison of non-typhoidal Salmonella from humans and food animals using pulsed-field gel electrophoresis and antimicrobial susceptibility patterns. | PLoS ONE 8(10): e77836. doi.1371/journal.pone.0077836. 2013.
  • Antimicrobial resistance genes in multidrug-resistant Salmonella enterica isolated from animals, retail meats, and humans in the United States and Canada.Glenn, L.M., Lindsey, R.L., Folster, J.P., Pecic, G., Boerlin, P., Gilmour, M.W., Harbottle, H., Zhao, S., McDermott, P.F., Fedorka-Cray, P.J., Frye, J.G. | Microbial Drug Resistance. 19(3):175-184. 2013.
  • Occurrence of beta-lactamase genes among non-typhi Salmonella enterica isolated from humans, food animals, and retail meats in the United States and Canada. | Microbial Drug Resistance. 19(3):191-197. 2013.
  • Epidemiology and genotypic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) of porcine origin.Molla, B., Byrne, M., Abley, M., Mathews, J., Jackson, C., Fedorka-Cray, P., Sreevatsan, S., Wang, P., Gebreyes, W. | 50(11):3687-3693. 2012.
  • Comparison of individual, pooled, and composite fecal sampling for detection of Salmonella on U.S. dairy operations.Lombard, J.E., Beam, A.L., Nifong, E.M., Fossler, C.P., Kopral, C.A., Dargatz, D.A., Wagner, B.A., Erdman, M.M., Fedorka-Cray, P.J. | Journal of Food Protection. 75(9):1562-1571. 2012.
  • Characterization of extended-spectrum cephalosporin-resistant Salmonella enterica serovar Heidelberg isolated from food animals, retail meats, and humans in the United States 2009.Folster, J.P., Pecic, G., Singh, A., Duval, B., Rickert, Ayers, S., Abbott, J., McGlinchey, B., Baurt-Turpin, J., Haro, J., Hise, K., Fedorka-Cray, P.J., Whichard, J., McDermott, P. | Food borne Pathogens and Disease. 9(7):638-645. 2012.
  • Salmonella prevalence and antimicrobial susceptibility from the National Animal Health Monitoring System swine 2000 and 2006 studies.Haley, C.A., Dargatz, D.A., Bush, E.J., Erdman, M.M., Fedorka-Cray, P.J. | Journal of Food Protection. 75(3):428-436. 2012.
  • Analysis of Campylobacter jejuni whole genome DNA microarrays: Significance of prophage and hypervariable regions for discriminating isolates.Pittenger, L.G., Frye, J.G., McNerney, V., Reeves, J., Haro, J., Fedorka-Cray, P.J., Harrison, M.A., Englen, M.D. | Foodborne Pathogens and Disease. 9(5):473-479. 2012.
  • Characterization of multi-drug resistant Salmonella enterica serovar Heidelberg from a ground turkey-associated outbreak in the United States, 2011.Folster, J.P., Pecic, G., Rickert, R., Taylor, J., Zhao, S., Fedorka-Cray, P.J., Whichard, J., McDermott, P. | Antimicrobial Agents and Chemotherapy. 56(6):3465-3466. 2012.
  • Antimicrobial susceptibility to azithromycin among Salmonella enterica isolates from the United States. | Antimicrobial Agents and Chemotherapy. 55(9):3985-3989. 2011.
  • Single nucleotide polymorphisms that differentiate two subpopulations of Salmonella Enteritidis within phage type.Guard, J., Morales, C.A., Fedorka-Cray, P.J., Gast, R.K. | BMC Research Notes. 4:Article 369. 2011.
  • Prevalence, distribution, and molecular characterization of Salmonella recovered from swine finishing herds and a slaughter facility in Santa Catarina, Brazil. | International Journal of Food Microbiology. 151(3):307-313. 2011.
  • Microarray-based analysis of incA/C plasmid-associated genes from multidrug-resistant Salmonella enterica.Lindsey, R.L., Frye, J.G., Fedorka-Cray, P.J., Meinersmann, R.J. | Applied and Environmental Microbiology. 77(19):6991-6999. 2011.
  • Analysis of antimicrobial resistance genes detected in multidrug-resistant Salmonella enterica serovar Typhimurium isolated from food animals.Glenn, L.M., Lindsey, R.L., Frank, J.F., Meinersmann, R.J., Englen, M.D., Fedorka-Cray, P.J., Frye, J.G. | Microbial Drug Resistance. 17(3):407-418. 2011.
  • Related antimicrobial resistance genes detected in different bacterial species co-isolated from swine fecal samples.Frye, J.G., Lindsey, R.L., Meinersmann, R.J., Berrang, M.E., Jackson, C.R., Englen, M.D., Turpin, J.B., Fedorka-Cray, P.J. | 8(6):663-679. 2011.
  • Characterization of multidrug-resistant Escherichia coli by antimicrobial resistance profiles, plasmid replicon typing and pulsed-field gel electrophoresis.Lindsey, R.L., Frye, J.G., Thitaram, S.N., Meinersmann, R.J., Fedorka-Cray, P.J., Englen, M.D. | Microbial Drug Resistance. 17(2):157-163. 2011.
  • Application of chlorine dioxide to lessen bacterial contamination during broiler defeathering.Berrang, M.E., Meinersmann, R.J., Cox, N.A., Fedorka-Cray, P.J. | Journal of Applied Poultry Research. 20(1):33-39. 2011.