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Elisa Crisci, DVM MSc PhD Veterinary Health and Medicine

Assistant Professor of Virology

Office: 919/513.6255

Dr. Elisa Crisci studied Veterinary Medicine at the University of Bologna (Italy) and during the last years she joined the pathology department to participate in the immunopathology course. She became interested in virology and pigs during her final degree project when studying porcine circovirosis. After earning her DVM, she applied for a scholarship for an internship period at the Centre de Recerca en Sanitat Animal (CRESA), an animal health research institute in Barcelona, Spain.

While in Spain, Crisci earned her MSc and PhD in Veterinary Health and Medicine at CRESA, focusing her studies mainly on virus-like particles as vaccine vectors for animal viral diseases and animal host-virus interactions.

During her PhD, she worked with different porcine viruses including circovirus, influenza virus (FLU), porcine reproductive and respiratory syndrome virus (PRRSV), foot-and-mouth disease virus (FMDV) and classical swine fever. Additionally, thanks to CRESA she also acquired experience allowing her to work under high biosafety level conditions with Biolevel 3 zoonotic pathogens. Crisci also worked in applied virology with different companies, to develop the safety study for a viral vaccine (Pfizer), to set up experimental viral infection (HIPRA) and to study an immunomodulatory compound (Maymo) to improve porcine industry. During this period, she was working in contact with stakeholders and commercial industry trying to develop the research and the collaboration in porcine production. During her doctorate, Crisci performed several internships to gain skills in virology and immunology, in particular in Scotland, Belgium and Australia.

After completing her PhD, Crisci spent further time at CRESA using the pig as a large animal model for immune cell therapy performing in vivo dendritic cell tracking.
In February 2013, she moved to Sweden to work in human virology at the molecular virology division of Linköping University (LIU). There she investigated mainly the interaction between human viruses, immune cells and complement system as well as gained skills to analyze virus-host relationship at a more detailed level using new generation sequencing. At LIU, Crisci was involved in the academic environment and was able to gain experience in teaching and training DM and graduate students.
The experience at IKE department with various cutting edge genomics methodologies and knowledgeable human virologists and immunologists inspirited her to apply similar technology to veterinary science.
For that reason, in 2017, she moved back to her "first love" and joined INRA, the French public research institute dedicated to agricultural science in Jouy-en-Josas (Paris, France). There she again studied pig viruses, in particular PRRSV infection in lung immune cells.

Crisci joined the faculty at the College of Veterinary Medicine of North Carolina State University as an Assistant Professor in Virology. She defines herelf as a "viro-immunologist" and her research will address the virus-host interactions in porcine diseases with a focus on Influenza and PRRSV.

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Italian veterinary board
Swedish veterinary board
Swedish Virology society
PhD Veterinary Health and Medicine
Immunology, Infectious Diseases

Dr. Crisci's vision is to establish a lab to study pig viral infections and the interaction between viruses and immune system. The lab will focus on the innate humoral and cellular immunity, in particular on the complement and mononuclear phagocytes systems.

In addition, the lab will analyze the virus-host interactions and immune cell profiles using gold standard assays but also at a more detailed level with new genomics methodology to gain insight and knowledge to use in the design of new therapeutic/prophylactic measures against pig viral diseases that lack protective vaccines. The collaboration with the swine NC State group and other researchers or industries in NC will create synergies to achieve important goals for swine production.