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Christopher Dekaney, PhD

Assistant Professor

Contact:

cmdekane@ncsu.edu
Office: 919.513.6372

Affiliations
Postdoctoral Fellow Baylor College of Medicine 2001-2004
Instructor Baylor College of Medicine 2004-2007
Assistant Professor University of North Carolina 2007-2015
Certifications
BS Texas A&M University 1993 Biomedical Sciences
MS Texas A&M University 1996 Veterinary Anatomy
PhD Texas A&M University 2001 Veterinary Anatomy
Postdoctoral Baylor College of Medicine 2001-2004 Intestinal Cell Biology
Biological Barriers, Gastroenterology
The primary focus of my research program is studying and understanding mechanisms that influence intestinal stem cell proliferative status, particularly following damage. Our current lines of study involve delineating:
  1. the roles Paneth cells, from the intestinal epithelium, play in epithelial repair – particularly within the context of providing a stem cell niche,
  2. how enteric bacteria influence damage and repair of the intestinal mucosa – particularly communication between enteric bacteria and resident leukocytes within the lamina propria, and
  3. the influence growth factors have on repair – particularly DNA damage repair and stem cell expansion
Delineating how these compartments influence mucosal damage and repair will not only provide us a better understanding the mechanisms involved in these processes, but will ultimately lead us to therapies that can be used clinically to minimize such damage and potentially increase efficacy of chemotherapy and radiation strategies for treating cancer. I have experience mentoring students and post-doctoral fellows and have set up my lab to be conducive to training in the arena of basic science. As I am still gaining experience mentoring M.D. fellows I have accumulated a group of senior clinical and basic science faculty at UNC to aid me in providing sound laboratory and career mentorship.

  • Isolation and Characterization of a Putative Intestinal Stem Cell Fraction from Mouse JejunumC.M. Dekaney, J. Rodriguez, M.C. Graul, and S.J. Henning | Gastroenterology 129:1567-1580, 2005
  • Rapid Expansion of Intestinal Secretory Lineages Following a Massive Small Bowel Resection in MiceM.A. Helmrath, J.J. Fong, C.M. Dekaney, S.J. Henning | American Journal of Physiology 292:G215-G222, 2007
  • Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in miceC.M. Dekaney, J.J. Fong, R.J. Rigby, P.K. Lund, S.J. Henning, and M.A. Helmrath | American Journal of Physiology 293:G1013-G1022, 2007
  • Bacterial-Dependent Up-Regulation of Intestinal Bile Acid Binding Protein and Transport is FXR-Mediated Following Ileo-Cecal ResectionC.M. Dekaney, D.C. von Allmen, A.P. Garrison, R.J. Rigby, P.K. Lund, S.J. Henning, and M.A. Helmrath | Surgery 144:174-181, 2008
  • Helmrath. Early Administration of Glucagon-Like Peptide-2 Following Ileo-cecal Resection Augments Putative Intestinal Stem Cell Expansion in MiceA.P. Garrison, C.M. Dekaney, D.C. von Allmen, P.K. Lund, S.J. Henning, M.A. | American Journal of Physiology 296:G643-G650, 2009
  • Regeneration of intestinal stem cells following doxorubicin treatment of miceC.M. Dekaney, A.S. Gulati, A.P. Garrison, M.A. Helmrath, and S.J. Henning | American Journal of Physiology 297:G461-G470, 2009
  • Expansion of Intestinal Epithelial Stem Cells During Murine DevelopmentJ.J. Dehmer, A.P. Garrison, K.E. Speck, C.M. Dekaney, L.V. Landeghem, X. Sun, S.J. Henning, M.A. Helmrath | Plos One 6:e27070, 2011
  • Small Intestinal Stem CellsS.L. King and C.M. Dekaney | Current Opinion in Gastroenterology 29:140-145, 2013
  • Paneth Cells Expand from Newly Created and Pre-existing Cells During Repair After Doxorubicin-Induced DamageS.L. King, J.J. Mohuiddin, and C.M. Dekaney | Am J Physiol Gastrointest Liver Physiol. 305:G151-G162, 2013
  • Henning. Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damageK. Seiler, E. Schenhals, R. von Furstenberg, B. Allena, B. Smith, D. Scaria, M. Bresler, C.M. Dekaney, and S.J. | Cell Tiss Res. 361:427-438, 2015