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Jonathan Fogle, DVM, Ph.D., DACVIM

Assistant Professor, Microbiology and Immunology

Contact:

jefogle@ncsu.edu
Office: 919.513.6248
Lab: Clinical Pathology
Lab Phone: 919.513.6550
Lab Fax: 919.513.6556

Certifications
Diplomate, American College of Veterinary Internal Medicine
Immunology
Identifying the mechanisms of CD8+ T cell suppression and how to rescue virus-specific CD8+ proliferation using the FIV model for HIV.

Examination of a novel compound LM11A-31 for neuro-protective effects using the FIV model.

Assess the utility of sCD14 as a biomarker for bacterial translocation in horses, dogs and cats.

Acquire a deeper understanding of the heterogeneity of canine monocytes by defining monocyte subpopulations, with specific emphasis on monocytes in dogs with osteosarcoma that also have an infected surgical site.

  • (2016) Canine osteosarcoma influences monocyte phenotype and chemotactic function.Tuohy J, Lascelles BDX, Griffith E, Fogle J. | J Vet Intern Med. 30(4):1167-78. doi: 10.1111/jvim.13983. Epub 2016 Jun 23. PMID: 27338235
  • (2016) Precision medicine in cats: novel Niemann-Pick Type C1 diagnosed by whole genome sequencing.Mauler DA, Gandolfi B, Reinero CR, O’Brien DP, Spooner JL, Lyons LA, 99 Lives Consortium. | J Vet Intern Med. Accepted August, 2016 (member of the 99 Lives Consortium for feline genomic sequencing)
  • (2016) Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression.Faiz NM, Cortes AL, Guy JS, Fogle JE, Gimeno IM. | Vaccine. 2016 Jul 29;34(35):4180-7. doi: 10.1016/j.vaccine.2016.06.061. Epub 2016 Jun 28.
  • (2016) Comparison of LPS and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses.J Fogle, M Jacob, A Blikslager, A Edwards, B Wagner, K Dean, C Fogle. | Equine Veterinary Journal, accepted, April 2016.
  • (2016) Canine osteosarcoma influences monocyte phenotype and chemotactic function.Tuohy JL, Lascelles BDX, Griffith EH, Fogle JE. | J Vet Intern Med, June, 2016 DOI: 10.1111/jvim.13983
  • (2016) Expression of apoptosis-regulating proteins Bcl-2 and Bax lymph node aspirates in dogs with lymphoma.K. Meichner, J. Fogle, L. English, SE. Suter. | J Vet Intern Med. Accepted February, 2016
  • (2015) CD45+ and CD45- lymphocyte populations identified by flow cytometry from dogs with lymphoma exhibit similar morphology and the same clonal (B cell or T cell) lineage.Fogle JE, Tarigo JL, Thalheim L, Williams LE, English LB, Suter SE. | Vet Immunol Immunopathol 2015 Dec 15;168(3-4):242-8. doi: 10.1016/j.vetimm.2015.10.004. Epub 2015 Oct 22.
  • CD4+CD25+ T regulatory cells activated during Feline Immunodeficiency Virus infection convert T helper cells into functional suppressors through a membrane-bound TGF?/ GARP-mediated mechanism.  Miller MM, Petty CS, Tompkins MB, Fogle JE.   | Virol J. 2014 Jan 18;11:7. doi: 10.1186/1743-422X-11-7
  • Lymphomaimmunophenotype of dogs determined by immunohistochemistry, flow cytometry, and polymerase chain reaction for antigen receptor rearrangements.Thalheim LLN, Suter SE, Borst L, Fogle JE, Williams L. | J Vet Intern Med. 2013 Nov-Dec;27(6):1509-16. doi:10.1111/jvim.12185. Epub 2013 Sep 20.PMID:24112291
  • Lentivirus-activated Tregulatory cells suppress T helper cell IL2 production by inhibiting NFAT2 binding to the IL2 promoter.Meng L, Tompkins MB, Miller MM, Fogle JE. | AIDS Res Hum Retroviruses. 2013 Aug 7. [Epub ahead of print] PMID: 23924068
  • Infection with Feline Immunodeficiency Virus Directly Activates CD4+CD25+ T Regulatory Cells. epub ahead of printMiller M.M., Fogle J.E., Tompkins M.B | Journal of Virology 2013. 10.1128/JVI.00996-13 JVI.00996-13, PMID: 2376025
  • Feline Glycoprotein A Repetitions Predominant (GARP) anchors TGFb on the surface of CD4+CD25+ regulatory T cells and mediates lentivirus induced T cell immunodeficiency.Miller M.M., Fogle J.E., Tompkins M.B. | AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. PMID: 23373523
  • CD8+ clonalityis associated with prolonged acute plasma viremia and altered mRNAcytokine profiles during the course of Feline Immunodeficiency Virus infection.Miller M.M., Thompson E. M., Suter S. E., Fogle J.E. | 2013 Apr 15;152(3-4):200-8.  PMID: 23332729
  • Human intravenous immunoglobulin (hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and canine monocytes in vitro.Sibley TA, Miller MM, Fogle JE | Vet Immunol Immunopathol. 2013 Feb 15;151(3-4):229-34. PMID: 23276750
  • Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection.Miller M.M., Fogle J.E. | Viruses. 2012; 4(6):954-962.
  • Fozivudine tidoxil as a single agent therapy reduces plasma and cell associated viremia during acute feline immunodeficiency virus infection.Fogle, J.E., Tompkins, W.A., Campbell B., Sumner D., Tompkins, M.B. | J Vet Intern Med Vol. 25 (3) May / June 2011
  • CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets.Fogle, J.E., Tompkins, W.A., Tompkins, M.B. | Retrovirology 7:97 Nov, 2010
  • CD4+CD25+ T regulatory cells inhibit CD8+ IFNg production during acute and chronic FIV infection utilizing a membrane TGF? dependent mechanism.Fogle, J.E., Mexas, A.M., Tompkins, W.A., Tompkins, M.B. | AIDS Res Hum Retroviruses., 26(2):201-16. Feb 2010
  • CD4+CD25+ Regulatory T cells are Infected and Activated During Acute FIV Infection.Mexas AM, Fogle JE, Tompkins WA, Tompkins MB. | Vet Immunol Immunopathol, 126(3-4) 2008.
  • In vivo depletion of CD4+CD25+ regulatory T cells in catsSmithberg SR, Fogle JE*, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, and Dean GA | J Immunol Methods., Jan 2008 (*co-primary author)
  • Mucosal Immunity and Canine Idiopathic Enteropathies.Fogle, JE, Bissett, SA. | Comp Cont Ed Pract Vet: Volume 29(5) May 2007.
  • Cholangiohepatitis in Cats. Fogle, JE, Bissett, SA.  | Standards of Care- Emerg Crit Care Med Vol 7.4 May 2005.
  • Pit Viper Envenomation in Dogs.Fogle, JE. | Standards of Care- Emerg Crit Care Med: Vol 6.8 Sep 2004.
  • Lymphomaimmunophenotype of dogs determined by immunohistochemistry, flow cytometry, and polymerase chain reaction for antigen receptor rearrangements.Thalheim LLN, Suter SE, Borst L, Fogle JE, Williams L. | J Vet Intern Med. 2013 Nov-Dec;27(6):1509-16. doi:10.1111/jvim.12185. Epub 2013 Sep 20.PMID:24112291
  • Lentivirus-activated Tregulatory cells suppress T helper cell IL2 production by inhibiting NFAT2 binding to the IL2 promoter.Meng L, Tompkins MB, Miller MM, Fogle JE. | AIDS Res Hum Retroviruses. 2013 Aug 7. [Epub ahead of print] PMID: 23924068
  • Infection with Feline Immunodeficiency Virus Directly Activates CD4+CD25+ T Regulatory Cells. epub ahead of printMiller M.M., Fogle J.E., Tompkins M.B | Journal of Virology 2013. 10.1128/JVI.00996-13 JVI.00996-13, PMID: 2376025
  • Feline Glycoprotein A Repetitions Predominant (GARP) anchors TGFb on the surface of CD4+CD25+ regulatory T cells and mediates lentivirus induced T cell immunodeficiency.Miller M.M., Fogle J.E., Tompkins M.B. | AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. PMID: 23373523
  • CD8+ clonalityis associated with prolonged acute plasma viremia and altered mRNAcytokine profiles during the course of Feline Immunodeficiency Virus infection.Miller M.M., Thompson E. M., Suter S. E., Fogle J.E. |
  • Human intravenous immunoglobulin (hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and canine monocytes in vitro.Sibley TA, Miller MM, Fogle JE | Vet Immunol Immunopathol. 2013 Feb 15;151(3-4):229-34. PMID: 23276750
  • Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection.Miller M.M., Fogle J.E. | Viruses. 2012; 4(6):954-962.
  • Fozivudine tidoxil as a single agent therapy reduces plasma and cell associated viremia during acute feline immunodeficiency virus infection.Fogle, J.E., Tompkins, W.A., Campbell B., Sumner D., Tompkins, M.B. | J Vet Intern Med Vol. 25 (3) May / June 2011
  • CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets.Fogle, J.E., Tompkins, W.A., Tompkins, M.B. | Retrovirology 7:97 Nov, 2010
  • CD4+CD25+ T regulatory cells inhibit CD8+ IFNg production during acute and chronic FIV infection utilizing a membrane TGF? dependent mechanism.Fogle, J.E., Mexas, A.M., Tompkins, W.A., Tompkins, M.B. | AIDS Res Hum Retroviruses., 26(2):201-16. Feb 2010
  • CD4+CD25+ Regulatory T cells are Infected and Activated During Acute FIV Infection.Mexas AM, Fogle JE, Tompkins WA, Tompkins MB. | Vet Immunol Immunopathol, 126(3-4) 2008.
  • In vivo depletion of CD4+CD25+ regulatory T cells in catsSmithberg SR, Fogle JE*, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, and Dean GA | J Immunol Methods., Jan 2008 (*co-primary author)
  • Mucosal Immunity and Canine Idiopathic Enteropathies.Fogle, JE, Bissett, SA. | Comp Cont Ed Pract Vet: Volume 29(5) May 2007.
  • Pit Viper Envenomation in Dogs.Fogle, JE. | Standards of Care- Emerg Crit Care Med: Vol 6.8 Sep 2004.
  • (2013) Lymphoma immunophenotype of dogs determined by immunohistochemistry, flow cytometry, and polymerase chain reaction for antigen receptor rearrangements.Thalheim L, Williams LE, Borst LB, Fogle JE, Suter SE. | J Vet Intern Med. 2013 Nov-Dec;27(6):1509-16. doi: 10.1111/jvim.12185. Epub 2013 Sep 20.
  • (2013) CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of feline immunodeficiency virus infection.Miller MM, Thompson EM, Suter SE, Fogle JE. | Vet Immunol Immunopathol. 2013 Apr 15;152(3-4):200-8. doi: 10.1016/j.vetimm.2012.12.005. Epub 2012 Dec 20.