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James Guy, DVM, PhD, DACVM, DACPV

Professor, Poultry Health Mangement

Contact:

jsguy@ncsu.edu
Office: 919.513.6287
Lab: Clinical Microbiology
Lab Phone: 919.513.6560
Lab Fax: 919.513.6568
Lab: Clinical Virology
Lab Phone: 919.513.6564
Lab Fax: 919.513.6703

Dr. James S. Guy received the D.V.M. degree in 1980 and Ph.D. in 1984, from the University of Tennessee, Knoxville. Dr. Guy is the advisor for the Virology section of the CVM Clinical Microbiology and Molecular Diagnostics Laboratory. His research focus is on viruses that adversely affect poultry production, including the study of infectious laryngotracheitis, turkey coronaviral enteritis, alphavirus-induced reproductive failure in turkeys, Marek’s disease virus-induced immune suppression and proventriculitis in broiler chickens. He participates in the NCSU Global Health Initiative as a member of the Latin America/Caribbean interest group; he travels frequently to South America to educate poultry veterinarians and producers on control and management of infectious laryngotracheitis. He is a member of the NCSU CVM Poultry Health Management Group and North Carolina Department of Agriculture Poultry Health Advisory Committee.

Academic Honors
Phibro Animal Health Excellence in Poultry Research Award, American Association of Veterinary Pathologists (2017)
Charles Beard Research Excellence Award, US Poultry and Egg Association (2013)
P. P. Levine Award, American Association of Avian Pathologists (2008). Awarded for best paper published in Avian Diseases, Vol. 51, 2007.
Pfizer Award for Excellence in Animal Research, Pfizer Animal Health (2003)
Distinguished Alumnus, College of Veterinary Medicine, University of Tennessee (2002)
Certifications
Diplomate, American College of Veterinary Microbiologists
Diplomate, American College of Poultry Veterinarians
Neurobiology
Proventriculitis in broiler chickens
Coronavirus and astrovirus infections of turkeys
Infectious laryngotracheitis
Enteric diseases of turkeys

  • 2018. Differential attenuation of Marek’s disease virus (MDV)-induced tumors and late MDV-induced immunosuppression.Faiz, N. M., A. L. Cortes, J. S. Guy, S. M. Reddy, and I. M. Gimeno. | Submitted to J Gen Virol.
  • 2017. The route of inoculation dictates replication patterns of infectious laryngotracheitis virus (ILTV) pathogenic strain and chicken embryo origin (CEO) vaccine.Beltran, L. G., S. M. Williams, G. Zavala, J. S. Guy, and M. Garcia. | Avian Pathol. 46:585-593.
  • 2017. Evaluation of factors influencing the development of late-Marek’s disease virus-induced immunosuppression: virus pathotype and host sex".Faiz, N. M., A. L. Cortes, J. S. Guy, J. E. Fogle, H. Liu and I. M. Gimeno. | Avian Pathol. 46:376-385.
  • 2016. Efficacy of various Marek’s disease vaccine protocols for prevention of Marek’s disease virus-induced immunosuppression.Faiz, N. M., A. L. Cortes, J. S. Guy, J. E. Fogle, H. Liu and I. M. Gimeno. | Vaccine 34:4180-4187.
  • 2016. Early infection with Marek’s disease virus can jeopardize protection conferred by laryngotracheitis vaccines: a method to study MDV-induced immunosuppression.Faiz, N. M., A. L. Cortes, O. J. Fletcher, J. S. Guy, and I. M. Gimeno. | Avian Pathol. 45:606-615.
  • 2016. Specific antibody responses to laryngotracheitis (LT) virus and fowl poxvirus (FPV) after vaccination with herpesvirus of turkeys- and FPV-vectored vaccines.Guy, J. S. and M. W. Byrd. | Proceedings of 11th International Conference on Marek’s disease virus and avian herpesviruses. Tours, France.
  • 2016. Turkey coronavirus.Jackwood, M. W. and J. S. Guy. | In: Isolation, Identification, and Characterization of Avian Pathogens, 6th ed.Am Assoc Avian Pathol, Athens, GA. Pp. 309-312.
  • 2016. Transmissible viral proventriculitis.Guy, J. S. | Isolation, Identification, and Characterization of Avian Pathogens, 6th ed. Am Assoc Avian Pathol, Athens, GA. Pp. 299-302.
  • 2016. Arbovirus infections.Guy, J. S. | In: Isolation, Identification, and Characterization of Avian Pathogens, 6th ed., Am Assoc Avian Pathol, Athens, GA. Pp. 151-156.
  • 2016. Viral encephalitides in poultry.Guy, J. S. | In: The Merck Veterinary Manual, 11th ed., Merck and Company, Inc., Whitehouse Station, NJ. Pp. 301-303.
  • 2016. Coronaviral enteritis of turkeys.Guy, J. S. | In: The Merck Veterinary Manual, 11th ed. Merck and Company, Inc. Whitehouse Station, NJ. Pp. 194-196.
  • 2015. Runting stunting syndrome associated with transmissible viral proventriculitis in broiler chickens.Noiva, R., J. S. Guy, R. Hauck, and H. L. Shivaprasad. | Avian Dis. 59:384-387..
  • 2015. Biological characterization of a serotype 1 Marek’s disease virus-vectored bivalent vaccine for infectious laryngotracheitis and Marek’s disease.Gimeno, I. M., A. L. Cortes, N. M. Faiz, B. A. Hernandez, J. S. Guy, H. D. Hunt, and R. F. Silva. | Avian Dis. 55:255-262.
  • 2015. Novel receptor specificity of avian gammacoronaviruses causing enteritis.Wickramasinghe, I. N., R. P. de Vries, E. A. Weerts, S. J. van Beurden, R. McBride, J. S. Guy, P. Brown, N. Eterradossi, A. Grone, J. C. Paulson, and M. H. Verheije. | J. Virol. 89:8703-8792.
  • 2015. Turkey coronavirus.Guy, J. S and J. P. Vaillancourt. | In: Manual of Poultry Diseases. J. Brugère-Picoux, J. P. Vaillancourt, M. Bouzouaia, H.L. Shivaprasad, and D. Venne, eds. Watt Publishing, Quebec. Pp. 242-247.
  • 2015. Isolation and propagation of coronaviruses in embryonated eggs.Guy, J. S. | In: Coronaviruses: Methods and Protocols. Methods in Molecular Biology. H. J. Maier, E. Bickerton, and P. Britton, eds. Springer, New York, NY.
  • 2014. Evaluation of recombinant infectious laryngotracheitis virus vaccines based on postchallenge virus replication in tracheas of vaccinated chickens. Guy, J. S., I. Gimeno, and M. A. West. | In preparation for submission to Avian Pathology.
  • 2014. A chicken embryo lethality assay for pathogenic Enterococcus cecorum.  Borst, L. B., M. Suyemoto, S. Keelara, S. E. Dunningan, J. S. Guy, and H. J. Barnes.  | Avian Diseases.          In Press.
  • 2014. A chicken embryo lethality assay for pathogenic Enterococcus cecorum.Borst, L. B., M. Suyemoto, S. Keelara, S. E. Dunningan, J. S. Guy, and H. J. Barnes. | Avian Dis. 58:232-243.
  • 2013.  Novel avian coronavirus and  fulminating disease in guinea fowl, France, 2010-2011.  Lias, E., G. Croville, J. Mariette, M. Delverdier, M. Lucas, C. Klopp, J. Lluch, C. Donnadieu,    J. S. Guy, L. Corrand, M. Ducatez, and J. Guerin. | Emerg. Infect. Dis. 20:105-108.
  • 2013. Novel avian coronavirus and fulminating disease in guinea fowl, France, 2010-2011.Lias, E., G. Croville, J. Mariette, M. Delverdier, M. Lucas, C. Klopp, J. Lluch, C. Donnadieu, J. S. Guy, L. Corrand, M. Ducatez, and J. Guerin. | Emerg. Infect. Dis. 20:105-108.
  • 2012. A case of enzootic nasal adenocarcinoma in a ewe.Stowe, D. M., K. L. Anderson, J. S. Guy, K. E. Linder and Carol Grindem. | Vet Med. http://www.hindawi.com/crim/vetmed/2012/347193/.
  • (2012) Transmissible viral proventriculitis identified in broiler breeder and layer hens.Marusak, R. A., West, M. A., Davis, J. F., Fletcher, O. J., Guy, J. S. | Avian Dis. 56 (4): 757-759. 2012
  • 2012. A case of enzootic nasal adenocarcinoma in a ewe.Stowe, D. M., K. L. Anderson, J. S. Guy, K. E. Linder and Carol Grindem. | Vet Med. http://www.hindawi.com/crim/vetmed/2012/347193/.
  • 2012. Transmissible viral proventriculitis identified in broiler breeder and layer hens.Marusak, R. A., M. A. West, J. F. Davis, O. J. Fletcher, and J. S. Guy. | Avian Dis. 56:757-759.
  • 2011. Birnavirus-associated proventriculitis in broiler chickens in France.Marguerie, J., O. Leon, O. Albaric, J.S. Guy and J-L. Guerin. | Vet. Record 169:394-396.
  • 2011. Replication of recombinant herpesvirus of turkey expressing genes of infectious laryngotracheitis virus (rHVT-LT) in specific-pathogen-free and broiler chickens following in ovo and subcutaneous vaccination.Gimeno, I. M., A. L. Cortes, J. S. Guy, E. Turpin, and C. Williams. | Avian Pathol. 40:395-403. 
  • 2011. Detection of chicken proventricular necrosis virus (R11/3 virus) in experimental and naturally-occurring cases of transmissible viral proventriculitis with the use of a reverse-transcriptase PCR procedure. Guy, J. S., R. Marusak, F. J. Fuller, M. A. West, H. L. Shivaprasad, J. L. Davis, and O. J. Fletcher.  | Avian Dis. 55:70-75.
  • 2011. Physical and genomic characteristics identify chicken proventricular necrosis virus (R11/3 virus) as a novel birnavirus.Guy, J. S., M. A. West, and F. J. Fuller.   | Avian Dis. 55:2-7.
  • 2011. Birnavirus-associated proventriculitis in broiler chickens in France.Marguerie, J., O. Leon, O. Albaric, J.S. Guy and J-L. Guerin. | Vet. Record 169:394-396.
  • 2011. Replication of recombinant herpesvirus of turkey expressing genes of infectious laryngotracheitis virus (rHVT-LT) in specific-pathogen-free and broiler chickens following in ovo and subcutaneous vaccination.Gimeno, I. M., A. L. Cortes, J. S. Guy, E. Turpin, and C. Williams. | Avian Pathol.
  • 2011. Physical and genomic characteristics identify chicken proventricular necrosis virus (R11/3 virus) as a novel birnavirus. | Avian Dis. 55:2-7.
  • (2010) Parvovirus-associated cerebellar hypoplasia and hydrocephalus in day-old broiler chickens. Marusak, R. A., J. S. Guy, T. H. Aziz, M. A. West, O. J. Fletcher, and H. J. Barnes.  | Avian Dis. 54: 156-160. 2010
  • 2007. Genomic characterization of equine coronavirus. Zhang, J., J. S. Guy, E. J. Snijder, D. A. Denniston, P. J. Timoney, and U. B. R. Balasuriya.  | Virology 369:92-104.
  • 2007.  Experimental evaluation of Musca Domestica (Diptera: Muscidae), as a vector of Newcastle disease virus. Watson, D. W., E. Lastro, K. Rocheron, L. Smith, and J. S. Guy.  | J. Med. Entomol.  44:666-671.
  • 2007. Experimental reproduction of transmissible viral proventriculitis by infection of chickens with an adenovirus-like virus, isolate R11/3.Guy, J. S., H. J. Barnes, and L. G. Smith.  | Avian Dis. 51:58-65.  
  • 2007. Experimental reproduction of transmissible viral proventriculitis by infection of chickens with an adenovirus-like virus, isolate R11/3. | Avian Dis.
  • 2006. Virus-induced gastrointestinal diseases of chickens and turkeys. In: Avian Gut Function, Health and Disease, Proc 28th World Poultry Science Symposium.Guy, J. S. | CAB International Wallingford, United Kingdom. In Press.
  • 2006. Virus-induced gastrointestinal diseases of chickens and turkeys. In: Avian Gut Function, Health and Disease, Proc 28th World Poultry Science Symposium.Guy, J. S. | CAB International Wallingford, United Kingdom. In Press.
  • 2005. Propagation and partial characterization of an adenovirus-like virus isolated from broiler chickens with transmissible viral proventriculitis.Guy, J. S., H. J. Barnes, L. G. Smith, R. Owen, and F. J. Fuller. | Avian Diseases. In Press.
  • 2005. Viral encephalitides in poultry.Guy, J. S. | In: The Merck Veterinary Manual, 9th ed. Merck and Company, Inc. Pp. 2287-2289.
  • 2005. Propagation and partial characterization of an adenovirus-like virus isolated from broiler chickens with transmissible viral proventriculitis.Guy, J. S., H. J. Barnes, L. G. Smith, R. Owen, and F. J. Fuller. | Avian Diseases. In Press.
  • 2004. Mild Infectious Laryngotracheitis in Broiler Chickens in the Southeast.Sellers, H. S., M. García, J. R. Glisson, T. P. Brown, J. S. Sander, and J. S. Guy. | Avian Dis. 48:430-436.
  • 2004. Ranavirus infection associated with morbidity and mortality in a group of captive eastern box turtles (Terrapene carolina carolina).DeVoe, R., K. Geissler, D. Rotstein, G. Lewbart, and J. S. Guy. | J. Zoo and Wildlife Med. 35:534-543.
  • 2004. Antigenic and genomic characterization of turkey enterovirus-like virus (North Carolina, 1988 isolate): identification of the virus as turkey astrovirus 2.Guy, J. S., A. M. Miles, L. G. Smith, S. Schultz-Cherry, and F. J. Fuller. | Avian Dis. 48:206-211.
  • 2004. Mild Infectious Laryngotracheitis in Broiler Chickens in the Southeast. | Avian Dis. 48:430-436.
  • 2004. Ranavirus infection associated with morbidity and mortality in a group of captive eastern box turtles (Terrapene carolina carolina).DeVoe, R., K. Geissler, D. Rotstein, G. Lewbart, and J. S. Guy. | J. Zoo and Wildlife Med. 35:534-543.
  • 2003. Common RNA replication signals exist among group 2 coronaviruses despite a two cluster pattern of 5' and 3' UTR sequences.Wu, H. Y., J. S. Guy, D. Yooc, R. Vlasakd, E. Urbach, and D. A. Brian. | Virology 315:174-183.
  • 2003. Common RNA replication signals exist among group 2 coronaviruses despite a two cluster pattern of 5' and 3' UTR sequences.Wu, H. Y., J. S. Guy, D. Yooc, R. Vlasakd, E. Urbach, and D. A. Brian. | Virology 315:174-183.
  • 2003. Enhancement of enteropathogenic Escherichia coli pathogenicity in young turkeys by concurrent turkey coronavirus infection.Pakpinyo, S., D. H. Ley, H. J. Barnes, J. P. Vaillancourt, and J. S. Guy. | Avian Dis. 47:396-405.
  • 2003. Turkey viral hepatitis. In: Animal Health and Production Compendium.Guy, J. S. | CAB International Wallingford, United Kingdom. Pp. 313-314.
  • 2003. Laryngotracheitis.Guy, J. S., and T. J. Bagust. | In: Diseases of Poultry, 11th ed., Y. M. Saif, H. J. Barnes, A. Fadly, J. R. Glisson, L. R. McDougald, and D. E. Swayne. Iowa State University Press, Ames, Iowa. Pp. 121-134.
  • 2003. Turkey coronavirus enteritis.Guy, J. S. | In: Diseases of Poultry, 11th ed., Y. M. Saif, H. J. Barnes, A. Fadly, J. R. Glisson, L. R. McDougald, and D. E. Swayne. Iowa State University Press Ames, Iowa. Pp. 300-308.
  • 2003. Enhancement of enteropathogenic Escherichia coli pathogenicity in young turkeys by concurrent turkey coronavirus infection.Pakpinyo, S., D. H. Ley, H. J. Barnes, J. P. Vaillancourt, and J. S. Guy. | Avian Dis. 47:396-405.
  • 2003. Turkey viral hepatitis. In: Animal Health and Production Compendium.Guy, J. S. | CAB International Wallingford, United Kingdom. Pp. 313-314.
  • 2003. Laryngotracheitis.Guy, J. S., and T. J. Bagust. | In: Diseases of Poultry, 11th ed., Y. M. Saif, H. J. Barnes, A. Fadly, J. R. Glisson, L. R. McDougald, and D. E. Swayne. Iowa State University Press, Ames, Iowa. Pp. 121-134.
  • 2003. Turkey coronavirus enteritis.Guy, J. S. | In: Diseases of Poultry, 11th ed., Y. M. Saif, H. J. Barnes, A. Fadly, J. R. Glisson, L. R. McDougald, and D. E. Swayne. Iowa State University Press Ames, Iowa. Pp. 300-308.
  • 2002. Prevalence of enteropathogenic Escherichia coli in naturally-occurring cases of poult enteritis-mortality syndrome.Pakpinyo, S., D. H. Ley, H. J. Barnes, J. P. Vaillancourt, and J. S. Guy. | Avian Dis. 46:360-369.
  • 2002. Development of a competitive enzyme-linked immunosorbent assay for detection of turkey coronavirus antibodies.Guy, J. S., J. J. Breslin, L. G. Smith, and S. Pakpinyo. | Avian Dis. 46: 334-341.
  • 2002. Prevalence of enteropathogenic Escherichia coli in naturally-occurring cases of poult enteritis-mortality syndrome.Pakpinyo, S., D. H. Ley, H. J. Barnes, J. P. Vaillancourt, and J. S. Guy. | Avian Dis. 46:360-369.
  • 2002. Development of a competitive enzyme-linked immunosorbent assay for detection of turkey coronavirus antibodies.Guy, J. S., J. J. Breslin, L. G. Smith, and S. Pakpinyo. | Avian Dis. 46: 334-341.
  • (2000) Characterization of a coronavirus isolated from a diarrheic foal.Guy, J. S., J. J. Breslin, B. Breuheus, S. Vivrette, and L. G. Smith. | J. Clin. Microbiol. 38:4523-4526.
  • (2000) Comparison of virus isolation, immunohistochemistry and polymerase chain reaction procedures for detection of turkey coronavirus.Breslin, J. J., L. G. Smith, H. J. Barnes, and J. S. Guy. | Avian Dis. 44:624-631.
  • (2000) Turkey Coronavirus is more closely related to avian infectious bronchitis virus than to mammalian coronaviruses: a review.Guy, J. S. | Avian Path. 29:207-212.
  • (2000) High mortality and growth depression experimentally produced in young chickens by dual infection with enteropathogenic Esherichia coli and turkey coronavirus.Guy, J. S., L. G. Smith, J. J. Breslin, J. P. Vaillancourt and H. J. Barnes. | Avian Dis. 44:105-113.
  • (1999) Sequence analysis of the turkey coronavirus nucleocapsid gene and 3' untranslated region identifies the virus as a close relative of infectious bronchitis virus.Breslin, J. J., L. G. Smith, F. G. Fuller, and J. S. Guy. | Virus Research 65:187-198.