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Profile

Bruce Hammerberg, PhD

Professor, Parasitology

Contact:

bhammerb@ncsu.edu
Office: 919.513.7712

Academic Training:

B.S. Michigan State University 1967
D.V.M. Michigan State University 1970
College of Veterinary Medicine
M.S. Michigan State University 1974
Department of Biochemistry
Ph.D. Michigan State University 1977
Department of Microbiology and
Public Health
Positions Held:

Veterinary Practitioner, small animal clinic in New Haven, Connecticut, June to December 1970.

Veterinary Practitioner, small animal clinic in Charlotte, Michigan, January to September 1971.

Research Veterinarian, Center for Laboratory Animal Research, January to September 1971.

Research Associate, Department of Microbiology and Public Health at MSU, March 1974 to June 1975.

Assistant Professor, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, July 1977 to January 1982.

Associate Professor, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 1982 to 1987.

Professor, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 1987 to present.
Infectious Diseases
The focus of my research is on development of biological therapies for allergic diseases. Allergic diseases in dogs, cats and horses are important concerns for veterinary medicine; and, the near identical presentation and treatment approach in atopic dermatitis of dogs and humans encourages our efforts to work with canine atopic dermatitis for purposes of both veterinary and human medicine applications.
At this time I am generating and testing chimeric recombinant proteins with specificity for IgE and the high affinity receptor of IgE responsible for inflammatory mediator release from mast cells and basophils.
  • 2014. Effects of pentoxifylline on immediate and late-phase cutaneous reactions in response to anti-immunoglobulin E antibodies in clinically normal dogs.Pucheu-Haston, C, Kasparek, K, Stout, R, Kearney, M, Hammerberg, B. | Am. J. Vet. Res. 75: 152-160
  • 2013. Serum anti-Staphylococcus psuedintermedius IgE and IgG antibodies in dogs with atopic dermatitis.Bexley, J, Nuttall, TJ, Hammerberg, B, Fitzgerald, JR, Halliwell, RE. | Vet. Dermatol. 24: 19-24
  • 2014. Canine IgE. In: Bruce Hammerberg. Canine IgE. In: Veterinary Allergy. Ed. Ciara Noli, Aiden Foster and Wayne RosenKrantz.Hammerberg, B. | Wiley-Blackwell. 2013. In press.
  • 2010. A comparison of the clinical manifestations of feeding whole and hydrolysed chicken to dogs with hypersensitivity to the native protein.Ricci, R, Hammerberg, B, Paps, J, Contiero, B, Jackson, H. | Vet. Dermatol. 21: 358-366.
  • 2009. Canine Immunoglobulin E (IgE).Hammerberg, B. | Vet Immunol Immunopathol 7-12.
  • 2009. Levels of house dust mite-specific immunoglobulin E (IgE) in different cat populations using a monoclonal based anti-IgE enzyme-linked immunosorbent assay (ELISA).Bexley, J, Hogg, JE, Hammerberg, B, Halliwell, REW. | Vet Dermatol 20:562-568.
  • 2008. Epicutaneous Sensitization with Dermatophagoides farinae Induces Generalized Allergic Dermatitis and Elevated Mite-Specific Immunoglobulin E Levels in a Canine Model of Atopic Dermatitis.Pucheu-Haston, CM, Jackson, HA, Olivry, T, Dunston, SM, Hammerberg, B. | Clin Expl Allergy 38:667-679.
  • 2007. A Novel Gene from Brugia sp. that Encodes a Cytotoxic Fatty Acid Binding Protein Allergen Recognized by Canine Monoclonal IgE and Serum IgE from Infected Dogs.Orton, SM, Arasu, P, Hammerberg, B. | J Parasitol 93:1378-1387.
  • 2006. A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.Pucheu-Haston, CM, Shuster, D, Olivry, T, Brianceau, P, Lockwood, P, McClanahan, T, de Waal Malefyt, R, Mattson, JD, Hammerberg, B. | Immunology 117:177-187.
  • 2005. Routine prophylactic vaccination enhances an allergen specific serum IgE and IgG response in allergic dogs but this response is not seen with aluminum adjuvant alone.Tater C, Jackson HA, Paps J, Hammerberg B. | Am J Vet Res 66:1572-1577.
  • Chapter 4: Canine Immune System.Hammerberg, B. | In: Animal Models of Human Inflammatory Skin Diseases. Pp. 79 -90. Ed. Lawrence S. Chan. CRC Press, Boca Raton, Fl. 2004.
  • 2003. Evaluation of the clinical and allergen specific serum IgE response to oral challenge with cornstarch, corn, soy and a soy hydrolysate in dogs with spontaneous food allergy.Jackson, H.A., Jackson, M.W., Coblentz, L., Hammerberg, B. | Vet. Derm. 14:181-187.
  • 2003. Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina.Little, D., Flowers, J.R., Hammerberg, B., Gardner, S.Y. | Equine Veterinary Journal 35:246-251.
  • 2003. Assessment of protein allergenicity on the basis of immune reactivity: animal models.Kimber, I., Dearman, R.J., Penninks, A.H., Knippels, L.M.J., Buchanan, R.B., Hammerberg, B., Jackson, H.A. and Helm, R.M. | Environmental Health Perspectives 111:1125-1130.
  • 2003. Synthetic IgE peptide vaccine for immunotherapy of allergy.Wang, C.Y., Walfield, A.M., Fang, X., Hammerberg, B., Ming, J.Y., Li, L., Shen, M., Alexander, V., MacGlashan, D.W. | Vaccine 21:1580-1590.
  • 2002. Evaluation of a spontaneous canine model of IgE mediated food hypersensitivity: dynamic changes in serum, faecal and allergen-specific IgE relative to dietary change.Jackson, H. A., Smith, C., Hammerberg, B. | Comp. Med. 52:316-321.
  • 2000. Identification of a collectin-llike protein in pig serum that binds a component in perienteric fluid from Ascaris suum.Watson BI, Hammerberg B. | Comp Immunol Microbiol Infect Dis 23:113-124.
  • 2000. Food hypersensitivity reaction in soft coated wheaten terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation and fecal immunoglobulin E.Vaden SL, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo T, Van Camp SD, Williams DA.SD. | Journal of Vet Int Med 14:60-67. http://www.cvm.ncsu.edu/dphp/personnel/hammerberg.html[8/12/2014 3:51:16 PM]
  • 2000. Natural killer cell-dependent immunoglobulin G2a anti-bovine serum albumin (BSA) reponse elicited by high molecular weight dextran-BSA conjugates associated with dextran-mediated macrophage-NK cell interaction.Ediriwickrema CS, Tonkonogy S, Hammerberg B. | Immunology. 101: 474-483.
  • 1998. Association of elevated lymph node cell release of histamine and tumor necrosis factor with genetic predisposition to limb edema formation in dogs infected with Brugia pahangi.Orton SM, Weinstock D, Hammerberg B. | Am J Trop Med Hyg. 58:695-704.
  • 1997. Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis.Hammerberg B, Bevier D, DeBoer DJ, Olivry T, Orton SM, Gebhard D, Vaden SL. | Vet Immunol Immunopathol 60:33-46.
  • Inhibition by platelets of invitro blastogenic responses of canine PBMC by a PAF-dependent mechanism.Schreuer D. and Hammerberg B. | Vet. Immunol. and Immunopathol. 52:135-145, 1996
  • Canine IgE monoclonal antibody specific for a filarial antigen: production by a canine X murine heterohybridoma using B cells from a clinically affected lymph node.Gebhard D., Orton S., Edmiston D., Nakagaki K., DeBoer D. and Hammerberg B. | Immunology 85:429-434, 1995
  • Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs.Schreuer D. and Hammerberg B. | Immunology 79:658-666, 1993
  • Inhibition of antigen-driven proliferative responses and enhancement of antibody production during infection with Brugia pahangi.Miller S., Schreuer D. and Hammerberg B. | J. Immunol. 147:1007-1013, 1991
  • 2014. A study for characterization of IgE-mediated cutaneous immediate and late-phase reactions in non-allergic domestic cats.SSeals, SL, Kearney, M, Del Piero, F, Hammerberg, B, Pucheu-Haston, CM. | Vet. Immunol. Immunopathol. (in press) on line http://dx.doi.org/10.1016/j.vetimm.2014.02.007
  • 2000. Natural killer cell-dependent immunoglobulin G2a anti-bovine serum albumin (BSA) reponse elicited by high molecular weight dextran-BSA conjugates associated with dextran-mediated macrophage-NK cell interaction.Ediriwickrema CS, Tonkonogy S, Hammerberg B. | Immunology. 101: 474-483.
  • 1998. Association of elevated lymph node cell release of histamine and tumor necrosis factor with genetic predisposition to limb edema formation in dogs infected with Brugia pahangi.Orton SM, Weinstock D, Hammerberg B. | Am J Trop Med Hyg. 58:695-704.
  • 1997. Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis.Hammerberg B, Bevier D, DeBoer DJ, Olivry T, Orton SM, Gebhard D, Vaden SL. | Vet Immunol Immunopathol 60:33-46.
  • Inhibition by platelets of invitro blastogenic responses of canine PBMC by a PAF-dependent mechanism.Schreuer D. and Hammerberg B. | Vet. Immunol. and Immunopathol. 52:135-145, 1996
  • Canine IgE monoclonal antibody specific for a filarial antigen: production by a canine X murine heterohybridoma using B cells from a clinically affected lymph node.Gebhard D., Orton S., Edmiston D., Nakagaki K., DeBoer D. and Hammerberg B. | Immunology 85:429-434, 1995
  • Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs.Schreuer D. and Hammerberg B. | Immunology 79:658-666, 1993
  • Inhibition of antigen-driven proliferative responses and enhancement of antibody production during infection with Brugia pahangi.Miller S., Schreuer D. and Hammerberg B. | J. Immunol. 147:1007-1013, 1991
  • 2014. A study for characterization of IgE-mediated cutaneous immediate and late-phase reactions in non-allergic domestic cats.SSeals, SL, Kearney, M, Del Piero, F, Hammerberg, B, Pucheu-Haston, CM. | Vet. Immunol. Immunopathol. (in press) on line http://dx.doi.org/10.1016/j.vetimm.2014.02.007
  • 2014. Effects of pentoxifylline on immediate and late-phase cutaneous reactions in response to anti-immunoglobulin E antibodies in clinically normal dogs.Pucheu-Haston, C, Kasparek, K, Stout, R, Kearney, M, Hammerberg, B. | Am. J. Vet. Res. 75: 152-160
  • 2013. Serum anti-Staphylococcus psuedintermedius IgE and IgG antibodies in dogs with atopic dermatitis.Bexley, J, Nuttall, TJ, Hammerberg, B, Fitzgerald, JR, Halliwell, RE. | Vet. Dermatol. 24: 19-24
  • 2014. Canine IgE. In: Bruce Hammerberg. Canine IgE. In: Veterinary Allergy. Ed. Ciara Noli, Aiden Foster and Wayne RosenKrantz.Hammerberg, B. | Wiley-Blackwell. 2013. In press.
  • 2010. A comparison of the clinical manifestations of feeding whole and hydrolysed chicken to dogs with hypersensitivity to the native protein.Ricci, R, Hammerberg, B, Paps, J, Contiero, B, Jackson, H. | Vet. Dermatol. 21: 358-366.
  • 2009. Canine Immunoglobulin E (IgE).Hammerberg, B. | Vet Immunol Immunopathol 7-12.
  • 2009. Levels of house dust mite-specific immunoglobulin E (IgE) in different cat populations using a monoclonal based anti-IgE enzyme-linked immunosorbent assay (ELISA).Bexley, J, Hogg, JE, Hammerberg, B, Halliwell, REW. | Vet Dermatol 20:562-568.
  • 2008. Epicutaneous Sensitization with Dermatophagoides farinae Induces Generalized Allergic Dermatitis and Elevated Mite-Specific Immunoglobulin E Levels in a Canine Model of Atopic Dermatitis.Pucheu-Haston, CM, Jackson, HA, Olivry, T, Dunston, SM, Hammerberg, B. | Clin Expl Allergy 38:667-679.
  • 2007. A Novel Gene from Brugia sp. that Encodes a Cytotoxic Fatty Acid Binding Protein Allergen Recognized by Canine Monoclonal IgE and Serum IgE from Infected Dogs.Orton, SM, Arasu, P, Hammerberg, B. | J Parasitol 93:1378-1387.
  • 2006. A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.Pucheu-Haston, CM, Shuster, D, Olivry, T, Brianceau, P, Lockwood, P, McClanahan, T, de Waal Malefyt, R, Mattson, JD, Hammerberg, B. | Immunology 117:177-187.
  • 2005. Routine prophylactic vaccination enhances an allergen specific serum IgE and IgG response in allergic dogs but this response is not seen with aluminum adjuvant alone.Tater C, Jackson HA, Paps J, Hammerberg B. | Am J Vet Res 66:1572-1577.
  • Chapter 4: Canine Immune System.Hammerberg, B. | In: Animal Models of Human Inflammatory Skin Diseases. Pp. 79 -90. Ed. Lawrence S. Chan. CRC Press, Boca Raton, Fl. 2004.
  • 2003. Evaluation of the clinical and allergen specific serum IgE response to oral challenge with cornstarch, corn, soy and a soy hydrolysate in dogs with spontaneous food allergy.Jackson, H.A., Jackson, M.W., Coblentz, L., Hammerberg, B. | Vet. Derm. 14:181-187.
  • 2003. Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina.Little, D., Flowers, J.R., Hammerberg, B., Gardner, S.Y. | Equine Veterinary Journal 35:246-251.
  • 2003. Assessment of protein allergenicity on the basis of immune reactivity: animal models.Kimber, I., Dearman, R.J., Penninks, A.H., Knippels, L.M.J., Buchanan, R.B., Hammerberg, B., Jackson, H.A. and Helm, R.M. | Environmental Health Perspectives 111:1125-1130.
  • 2003. Synthetic IgE peptide vaccine for immunotherapy of allergy.Wang, C.Y., Walfield, A.M., Fang, X., Hammerberg, B., Ming, J.Y., Li, L., Shen, M., Alexander, V., MacGlashan, D.W. | Vaccine 21:1580-1590.
  • 2002. Evaluation of a spontaneous canine model of IgE mediated food hypersensitivity: dynamic changes in serum, faecal and allergen-specific IgE relative to dietary change.Jackson, H. A., Smith, C., Hammerberg, B. | Comp. Med. 52:316-321.
  • 2000. Identification of a collectin-llike protein in pig serum that binds a component in perienteric fluid from Ascaris suum.Watson BI, Hammerberg B. | Comp Immunol Microbiol Infect Dis 23:113-124.
  • 2000. Food hypersensitivity reaction in soft coated wheaten terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation and fecal immunoglobulin E.Vaden SL, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo T, Van Camp SD, Williams DA.SD. | Journal of Vet Int Med 14:60-67. http://www.cvm.ncsu.edu/dphp/personnel/hammerberg.html[8/12/2014 3:51:16 PM]