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Megan Jacob, MS, PhD

Associate Professor and Director of Diagnostic Laboratories

Office: 919.513.6236
Lab: Clinical Microbiology
Lab Phone: 919.513.6560
Lab Fax: 919.513.6568

Dr. Megan Jacob is an Assistant Professor and Director of the Clinical Microbiology Laboratory at the North Carolina State University College of Veterinary Medicine. She came to Raleigh after completing her undergraduate education in microbiology at the University of Wyoming and her MS, PhD and post-doctoral work in veterinary pathobiology at Kansas State University. Her graduate and post-doctoral research programs were focused on the epidemiology and ecology of foodborne pathogens, specifically E. coli O157 and Salmonella in feedlot cattle. In addition to Megan's continued research interest in pre-harvest food safety and transmission dynamics of pathogenic bacteria, she has developed a research program in veterinary diagnostic microbiology, specifically evaluating and implementing new diagnostic assays. Megan aims to be at the forefront in advancements in diagnosing and monitoring antimicrobial resistant organisms in animal populations, and continuously works to improve the laboratory diagnostic experience for veterinary clinicians.
American Society of Microbiology
International Association for Food Protection
Clinical and Laboratory Standards Institute
American Association of Veterinary Laboratory Diagnosticians
Phi Zeta Honor Society of Veterinary Medicine
Conference of Research Workers in Animal Diseases
Infectious Diseases
Antimicrobial Resistance
E. coli transmission and ecology
Bacteriology diagnostics
  • (2016) Efficacy of an Escherichia coli O157:H7 SRP® vaccine in orally challenged goats and strain persistence over time.Swift, J., D. M. Foster, A. T. Rogers, H. Sylvester, E. H. Griffith, M. E. Jacob*. | Foodborne Pathogens and Disease Submitted
  • (2016) In vivo evaluation of silver releasing nanofibers to address surgical site infection with MRSA using a newly developed porcine modelMohiti-Asli, M., M. Risselada, M. E. Jacob, B. Pourdeyhimi, and E. G. Loboa*. | Acta Biomaterialia Submitted
  • (2016) Effect of high pressure processing of bovine colostrum on IgG concentration, pathogens, viscosity and transfer of passive immunity to calvesFoster, D.*, K. Poulsen, H. Sylvester, M. Jacob, K. Casulli, B. Farkas. | J. Dairy Science Accepted
  • (2016) Molecular confirmation of shampoo as the putative source of Pseudomonas aeruginosa-induced postgrooming furunulosis in a dog.Tham, H., M. Jacob, P. Bizikova*. | Vet Derm. 27:32-e80
  • (2016) Comparison of LPS and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horsesFogle, J.*, M. Jacob, A. Blikslager, A. Edwards, B. Wagner, K. Dean, and C. Fogle. | Equine Vet J. In press. doi: 10.1111/evj.12582
  • (2016) Establishing a canine superficial pyoderma modelBaeumer, W.*, P. Bizikova, M. Jacob, K. Linder. | J. Appl. Microbiol. In press
  • (2016) Evaluation of a rapid immunoassay for point-of-care detection of canine urinary tract infectionJacob, M.E. *, M. D. Crowell, M. B. Fauls, E. H. Griffith, and K. K. Ferris. | Amer J. Vet. Res. 77:162-166
  • (2016) Pharmacokinetics of enrofloxacin and ceftiofur in plasma, interstitial fluid, and gastrointestinal tract of calves after subcutaneous injection, and bactericidal impacts on representative enteric bacteriaFoster, D. M.*, M. E. Jacob, C. D. Warren, and M. G. Papich. | J Vet Pharmacol Ther. 39:62-71
  • (2016) Feeding wet distillers grains plus solubles with and without a direct-fed microbial to determine performance, carcass characteristics, and fecal shedding of Escherichia coli O157:H7 in feedlot heifersWilson, B. K., B. P Holland, D. L. Sep, M. E. Jacob, D. L. VanOverbeke, C. J. Richards, T. G. Nagaraja, and D. R. Krehbiel* | J. Anim. Science 94: 297-305
  • (2016) Isolation and characterization of atypical Listeria monocytogenes associated with a canine urinary tract infectionPalerme, J.S., P.C. Pan, C. T. Parsons, S. Kathariou, T. J. Ward, and M. E. Jacob*. | J Vet Diag Investig. Published online before print August 4, 2016, doi:10.1177/1040638716661381.
  • (2016) Listeria monocytogenes septicemia in an immunocompromised dogPritchard, J., M. E. Jacob, T. Ward, S. Kathariou, C. Parsons, and M. Wood*. | Vet Clin Path. 45:254-259
  • (2015) Deep pyoderma caused by Burkholderia cepacia complex in dogs treated with oral ciclosporin.Banovic, F., S. Koch, D. Robson, M. Jacob, and T. Olivry*. | Vet Derm. 26:287-e64.
  • (2015) Attitudes of clinical veterinarians at a U. S. veterinary teaching hospital toward antimicrobial use and antimicrobial-resistant infectionsJacob, M. E.*, J. A. Hoppin, N. Steers, J. L. Davis, G. Davidson, B. Hansen, K. F. Lunn, K. M. Murphy, and M. G. Papich. | J. Amer. Vet. Med. Assoc. 247:938-944
  • (2014) Implantation of an ultrafiltration device in the ileum and spiral colon of steers to continuously collect intestinal fluidWarren, C. D., T. Prange, N. B. Campbell, M. P Gerard, L. G Martin, M. E. Jacob, G. W. Smith, M. G. Papich, and D. M. Foster*. | Res. Vet. Sci. 97:611-615.
  • (2014) Edwardsiella tarda and Aeromonas hydrophila isolated from diseased Southern flounder (Paralichthys lethostigma) are virulent to channel catfish and Nile tilapia.Pridgeon, J. W. *, P. H. Klesius, G. A. Lewbart, H. V. Daniels, and M. Jacob. | J. Coastal Life Med. 2:337-343
  • (2014) Vaginal microbiota of spayed dogs with or without recurrent urinary tract infections.Hutchins, R. G., S. L. Vaden, M. E. Jacob, T. L. Harris, K. D. Bowles, M. W. Wood, and C. S. Bailey* | J. Vet. Internal Med. 28:300-304
  • (2014) Comparing real-time and conventional PCR to culture-based methods for detecting and quantifying Escherichia coli O157 in cattle feces.Jacob, M. E.*, J. Bai, D. G. Renter, A. T. Rogers, X. Shi, and T. G. Nagaraja. | J. Food Prot. 77:314-319
  • (2013) Prevalence and relatedness of E. coli O157:H7 in the feces and on the hides and carcasses of U. S. meat goats at slaughter.Jacob, M. E.*, D. M. Foster, A. T. Rogers, C. C. Balcomb, and M. W. Sanderson. | Appl. Environ. Microbiol. 79:4154-4158.
  • (2013) Evidence of non-O157 Shiga toxin-producing Escherichia coli in the feces of meat goats at a U.S. slaughter plant.Jacob, M. E.*, D. M. Foster, A. T. Rogers, C. C. Balcomb, X. Shi, and T. G. Nagaraja. | J. Food Prot. 76:1626-1629.
  • (2013) The effect of an oral probiotic containing Lactobacillus, Bifidobacterium, and Bacillus species on the vaginal microbiota of spayed female dogsHutchins, R. G., C. S. Bailey, M. E. Jacob, T. L. Harris, M. W. Wood, K. Saker, and S. L. Vaden*. | J. Vet. Internal Med. 27: 1368-1371.
  • (2012) Evaluation of a multiplex real-time PCR for the quantification of Escherichia coli O157 in cattle fecesJacob, M. E., X. Shi, B. An, T. G. Nagaraja, and J. Bai*. | Foodborne Pathog. Dis. 9:79-85.
  • (2011) Escherichia coli O157:H7 genetic diversity in bovine fecal samples.Jacob, M. E. *, K. M. Almes, X. Shi, J. M. Sargeant, and T. G. Nagaraja. | J. Food Prot. 74:1186-1188.
  • (2011) Modeling preharvest and harvest interventions for Escherichia coli O157 contamination of beef cattle carcasses.Dodd, C. C., M. W. Sanderson*, M. E. Jacob, and D. G. Renter. | J. Food Prot. 74:1422-1366.
  • (2010) Feeding dried or wet distiller’s grains at various inclusion levels to feedlot cattle affects the fecal prevalence of Escherichia coli O157:H7.Jacob, M. E., D. G. Renter, Z. D. Paddock, K. F. Lechtenberg, and T. G. Nagaraja*. | Appl. Environ. Microbiol. 76:7238-7242.
  • (2010) Occurrence of tcrB, a transferable copper resistance gene, in fecal enterococci of swine.R. G. Amachawadi., N. W. Shelton, M. E. Jacob, X. Shi, S. K. Narayanan, L. Zurek, S. S. Dritz, J. L. Nelssen, M. D. Tokach, and T. G. Nagaraja. | Foodborne Pathog Dis. 7:1089-1097.
  • (2010) Animal- and truckload-level associations among E. coli O157:H7 in feces and hides at harvest and contamination of pre-intervention beef carcasses.Jacob, M.E., D. G. Renter, and T. G. Nagaraja | J. Food Prot. 73:1030-1037.
  • (2010) Effects of feeding elevated concentrations of copper and zinc on the antimicrobial susceptibilities of fecal bacteria in feedlot cattle.Jacob, M. E., J. T. Fox, T. G. Nagaraja, J. S. Drouillard, R. Amachawadi, and S. K. Narayanan. | Foodborne Pathog. Dis. 6:643:648.
  • (2009) Evaluation of feeding dried distiller’s grains with solubles and dry-rolled corn on the fecal prevalence of Escherichia coli O157:H7 and Salmonella spp. in cattle.Jacob, M. E., J. T. Fox, J. S. Drouillard, D. G. Renter, and T. G. Nagaraja. | Foodborne Pathog Dis. 2:145-153.
  • (2009) Dietary interactions and interventions affecting Escherichia coli O157 colonization and shedding in cattle.Jacob, M. E., T. R. Callaway, and T. G. Nagaraja. | Foodborne Pathog Dis. 6:785-792.
  • (2008) Effects of dried distillers’ grain on fecal prevalence and growth of Escherichia coli O157 in batch culture fermentations from cattle.Jacob, M. E., J. T. Fox, J. S. Drouillard, D. G. Renter, and T. G. Nagaraja. | Appl. Environ. Microbiol., 74(1):38-43.
  • (2008) Feeding supplemental dried distiller’s grains increases fecal shedding of Escherichia coli O157 in experimentally inoculated calves.Jacob, M. E., G. L. Parsons, M. K. Shelor, J. T. Fox, J. S. Drouillard, D. U. Thomson, D. G. Renter, and T. G. Nagaraja. | Zoonoses Publ. Hlth. 55(3):125-132.
  • (2008) Effects of feeding wet corn distiller’s grains with solubles with or without monensin and tylosin on the prevalence and antimicrobial susceptibilities of fecal food-borne pathogenic and commensal bacteria in feedlot cattle.Jacob, M. E., J. T. Fox, S. K. Narayanan, J. S. Drouillard, D. G. Renter and T. G. Nagaraja. | J. Anim. Sci. 86(5):1182-1190.
  • (2008) Niche marketing production practices for beef cattle in the United States and prevalence of foodborne pathogens.Fox, J. T., S. Reinstein, M. E. Jacob, and T. G. Nagaraja. | Foodborne Pathog Dis. 5:559-569.
  • (2008) Antimicrobial susceptibility of foodborne pathogens in organic or natural production systems: an overview.Jacob, M. E., J. T. Fox, S. L. Reinstein, and T. G. Nagaraja. | Foodborne Pathog Dis. 5:721-730.