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Tobias Kaeser, PhD

Assistant Professor in Swine Immunology

Contact:

tekaeser@ncsu.edu
Office: 919.513.6352

I studied biology at the Eberhard Karls University Tübingen (Germany) with a focus on molecular biology, virology and microbiology. Having become interested in immunology, I decided to perform my Diploma thesis and subsequently my PhD thesis at an immunological institute and thus joined the Institute of Immunology at the Vetmeduni Vienna. The focus of my theses was the characterisation of porcine regulatory T cells (Tregs). My following postdoctoral work was delving deeper into the function of Tregs, focusing on their part in Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. Besides, I was trying to identify new markers for several T-helper cell subsets in swine and to improve flow cytometry for veterinary medicine. Thereby, we became able to characterize porcine T-helper cell subsets and Tregs phenotypically and functionally by up to eight-color flow cytometry. In addition, I was an active member of the Austrian Society of Cytometry and participated in the planning and in the execution of basic and advanced courses and seminars. In September 2013, I moved to Saskatoon, Canada to work at VIDO to extend my knowledge on host-pathogen interactions. We were using the pig as a large animal model to study the cellular immune response on intracellular chlamydia infection. Joining this well-recognized institute gave me the ability to broaden my skills including the isolation and culture of bacteria and host cells, immunohistochemistry, and confocal microscopy. The insight into a new institution with various up-to-date methods and a wide experience with vaccine development made this decision a great success. In June 2016, I started as an Assistant Professor in swine immunology at the College of Veterinary Medicine at the North Carolina State University in Raleigh, North Carolina. My research will address the host-pathogen interactions in porcine diseases with a focus on Chlamydia suis. In addition, I will continue to establish and improve the usage of swine as a large animal model for vaccine development.
Affiliations
- Edward Jenner Vaccine Society
- German Society of Immunology (DGfI)
- Austrian Society for Cytometry (ÖGfZ)
Certifications
PhD Immunology
Immunology, Infectious Diseases
My vision is to establish a lab providing state-of-the-art immune response (IR) analyses covering all three branches of the immune system: the innate, the humoral and the cellular immune response. The focus will be on antigen-specific immune responses and we will create a precise detection system for the most relevant pig and human pathogens including C. suis and C. trachomatis to complete the analysis of the host-pathogen interactions. We will use this technology to develop a vaccine against C. suis and C. trachomatis, to test C. trachomatis vaccine candidates with promising results in rodent models, and to analyse host-pathogen-interactions in diseases relevant for the swine industry in co-operation with other research groups.
  • (2017) Chlamydia suis and Chlamydia trachomatis induce multifunctional CD4 T cells in pigs.Käser T., Pasternak J.A., Delgado-Ortega M., Hamonic G., Lai K., Erickson J., Walker S., Dillon J.R., Gerdts V., Meurens F. | Vaccine 35, 91-100
  • (2016) Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.Bähr A.*, Käser T., Kemter E., Gerner W., Kurome M., Baars W., Herbach N., Witter K., Wünsch A., Talker S.C., Kessler B., Nagashima H., Saalmüller A., Schwinzer R., Wolf E., Klymiuk N. | PLoS One 11(5), 1-22
  • (2016) Extended semen for artificial insemination in swine as a potential transmission mechanism for infectious Chlamydia suis.Hamonic G., Pasternak J.A., Käser T., Meurens F., Wilson H.L. | Theriogenology, doi 10.1016/j.theriogenology.2016.03.018
  • (2016) Flow cytometry as an improved method for the titration of Chlamydiaceae and other intracellular bacteria.Käser T.*, Pasternak J.A., Hamonic G., Rieder M., Lai K., Gerdts, V., Meurens F. | Cytometry Part A 89A, 451-460
  • (2016) Expression of T-bet, Eomesodermin and GATA-3 in porcine αβ T cells.Rodríguez-Gómez I.M., Talker S.C., Käser T, Stadler M., Hammer S.E., Saalmüller A., Gerner W.*, | Dev. Comp. Immunol. 60, 115-126
  • (2015) Porcine retinal cell line VIDO R1 and Chlamydia suis to modelize ocular chlamydiosis.Käser T., Cnudde T., Hamonic G., Rieder M., Pasternak J.A., Lai K., Tikoo S.K., Wilson H.L., Meurens F.* | Vet. Immunol. Immunopathol. 166, 95-107
  • (2015) Natural and inducible Tregs in swine: Helios expression and functional properties.Käser T.*, Mair K.H., Hammer S.E., Gerner W., Saalmüller A. | Dev. Comp. Immunol. 49, 323–331
  • (2015) PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate.Rodríguez-Gómez I.M., Käser T., Gómez-Laguna J., Lamp B., Sinn L., Rümenapf T., Carrasco L., Saalmüller A., Gerner W.* | Veterinary Research 46, 54-66
  • (2015) The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes.Paudel S., Hess C., Wernsdorf P., Käser T., Meitz S., Jensen-Jarolim E., Hess M., Liebhart D.* | Vet Immunol Immunopathol. 166, 22-32
  • (2014) Grouping Pig-Specific Responses to Mitogen with Similar Responder Animals may Facilitate the Interpretation of Results Obtained in an Out-Bred Animal Model.Pasternak J.A., Hon Ng S., Käser T., Meurens F., Wilson H.L.*, | J. Vaccines Vaccin. 5, 1-9
  • (2014) The porcine innate immune system: An update.Mair K.H., Sedlak C., Käser T., Pasternak J.A., Levast B., Gerner W., Saalmüller A., Summerfield A., Gerdts V., Wilson H.L., Meurens F.* | Dev. Comp. Immunol. 45, 321-343
  • (2013) Phenotypic maturation of porcine NK- and T-cell subsets.Talker S.C., Käser T., Reutner K., Sedlak C., Mair K.H., Koinig H., Graage R., Viehmann M., Klingler E., Ladinig A., Ritzmann M., Saalmüller A., Gerner W.* | Dev. Comp. Immunol. 40, 51-68
  • (2013) Human Placental Alkaline Phosphatase as a Tracking Marker for Bone Marrow Mesenchymal Stem Cells.Rosado Balmayor E., Flicker M., Käser T., Saalmüller A., Erben R.G.* | Biores Open Access. 2, 346–355
  • (2013) Immunohistochemical Characterization of Type II Pneumocyte Proliferation after Challenge with Type I Porcine Reproductive and Respiratory Syndrome Virus.Balka G.*, Ladinig A., Ritzmann M., Saalmüller A., Gerner W., Käser T., Jakab C., Rusvai M., Weißenböck H. | J. Comp. Pathol. J. Comp. Pathol. 149, 322– 330
  • (2012) Porcine T-helper and regulatory T-cells exhibit versatile mRNA expression capabilities for cytokines and co-stimulatory molecules.Käser T.*, Müllebner A., Hartl R.T., Essler S.E., Saalmüller A., Duvigneau C.J. | Cytokine 60, 400– 409
  • (2012) Current knowledge on porcine regulatory T cells.Käser T.*, Gerner W., Bolzer K., Hammer SE., Patzl M., Saalmüller A. | Vet. Immunol. and Immunopathol. 148, 136– 138
  • (2011) Porcine regulatory T cells: mechanisms and T-cell targets of suppressionKäser T.*, Gerner W., Saalmüller, A. | Dev. Comp. Immunol 35, 1166– 1172
  • (2009) Molecular characterisation of porcine Forkhead-box p3 (Foxp3).Bolzer K., Käser T., Saalmüller A., Hammer SE. | 132, 275–281
  • (2009) Porcine T lymphocytes and NK cells-an update.Gerner W., Käser T., Saalmüller A. | Dev. Comp Immunol. 33, 310-320.
  • (2008) Detection of Foxp3 protein expression in porcine T lymphocytes.Käser T., Gerner W., Hammer S.E., Patzl M., Saalmüller A. | Vet. Immunol Immunopathol. 125, 92-101.
  • (2008) Detection of intracellular antigens in porcine PBMC by flow cytometry: A comparison of fixation and permeabilisation reagents.Gerner W.*, Käser T., Pintaric M., Groiss S., Saalmüller A. | Vet. Immunol. Immunopathol. 121, 251-259.
  • (2008) Phenotypic and functional characterisation of porcine CD4(+)CD25(high) regulatory T cells. Vet.Käser T., Gerner W., Hammer S.E., Patzl M., Saalmüller A. | Immunol. *, Immunopathol. 122 (2008) 153–158.