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Freya Mowat, BVSc. PhD. Dipl. ECVO Dipl. ACVO

Assistant Professor, Ophthalmology

Contact:

fmmowat@ncsu.edu
Lab: Mowat Lab
Lab Phone: 919.513.6140

Freya Mowat received her veterinary degree from the University of Bristol, England in 2001, and worked in private mixed animal veterinary practice in Cumbria, England from 2001-2003. She completed a small animal rotating internship at Davies Veterinary Specialists from 2003-2004. She earned her PhD in 2009 from University College London, studying molecular mechanisms of oxygen sensing in the retina. She recently completed her combined residency and postdoctoral position in Comparative Ophthalmology at Michigan State University, and is currently an Assistant Professor of Ophthalmology at North Carolina State University. Dr. Mowat's research focuses on inherited dysfunction or degeneration of the retina and developing novel therapeutic strategies to treat these diseases.
Affiliations
Member, Royal College of Veterinary Surgeons
Member, Association of Research in Vision and Ophthalmology
Member, European College of Veterinary Ophthalmologists
Member, American College of Veterinary Ophthalmologists
Member, NCSU Comparative Medicine Institute
Member, NCSU Center for Human Health and the Environment
Certifications
Bachelor of Veterinary Science, University of Bristol, 2001
PhD., Molecular Genetics, University College London, 2009
Diplomate of the European College of Veterinary Ophthalmologists, 2015
Diplomate of the American College of Veterinary Ophthalmologists, 2015
Genetics, Neurobiology, Spontaneous Animal Disease Models
CLINICAL STUDIES
  • Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials.Minella AL, Mowat FM, Willett KL, Sledge D, Bartoe JT, Bennett J, Petersen-Jones SM. | Gene Therapy 2014; 21(10): 913-920 PMID: 25056608
  • Assessment of a novel pigmentary chorioretinopathy in the Chinese Crested dog.Narfström K, Jalomäki S, Mowat FM, Samardzija M, Chadieu G, Bergstrom T, Bragadottir R, Grimm C. | JSM Ophthalmology 2014; 2(2): 1018
  • Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach.Mowat FM, Gornik KR, Dinculescu A, Boye SL, Hauswirth WW, Petersen-Jones SM, Bartoe JT. | Gene Therapy 2014; 21(1):96-105. PMID: 24225638
  • RPE65 gene therapy slows cone loss in Rpe65-deficient dogs.Mowat FM, Bruewer A, Bartoe J, Annear M, Smith A, Bainbridge JW, Petersen-Jones S, Ali RR. | Gene Therapy 2013; 20(5): 545-55. PMID: 22951453
  • Successful gene therapy in older Rpe65-deficient dogs following subretinal injection of an adeno-associated vector expressing RPE65. Hum.Annear MJ, Mowat FM, Bartoe JT, Querubin J, Azam SA, Basche M, Curran PG, Smith AJ, Bainbridge JW, Ali RR, Petersen-Jones SM. | Gene Ther. 2013; 24(10): 883-93. PMID: 24028205
  • Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogs.Bruewer AR, Mowat FM, Bartoe JT, Boye SL, Hauswirth WW, Petersen-Jones SM. | PLoS One 2013; 8(4): e60218. PMID: 23560080
  • Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.Lange C, Luhmann UFO, Mowat FM, Georgiadis A, West EL, Abraham S, Sayed H, Powner M, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JWB. | Development 2012; 139(13): 2340-2350. PMID: 22627278
  • Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy.Mowat FM, Gonzalez F, Luhmann UFO, Lange C, Duran Y, Smith AJ, Maxwell PH, Ali RR, Bainbridge JWB | American Journal of Pathology 2012; 180(4): 1726-39. PMID: 22342523
  • HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.Mowat FM, Luhmann UFO, Smith AJ, Lange C, Duran Y, Harten S, Shukla D, Maxwell PH, Ali RR, Bainbridge JWB. | PLoS One 2010; 5(6): e11103. PMID: 20559438
  • The tight junction associated signalling proteins ZO-1 and ZONAB regulates retinal pigment epithelium homeostasis in mice.Georgiadis A, Tschernutter M, Bainbridge JWB, Balaggan KS, Mowat FM, West EL, Munro PMG, Thrasher AJ, Matter K, Balda M, Ali RR. | PLoS One 2010; 5(12): e15730. PMID: 21209887
  • Topographical characterization of cone photoreceptors and the area centralis of the canine retina.Mowat FM, Petersen-Jones SM, Williamson H, Williams DL, Luthert PJ, Ali RR, Bainbridge JW. | Mol. Vis. 2008; 14, 2518-2527. PMID: 19112529