Skip to main content


Gabriela Seiler, Dr. Med. Vet.

Associate Professor, Radiology

Office: 919.513.6217

Dr. Gabriela Seiler received her Doctor of Veterinary Medicine degree from the University of Bern, Switzerland and worked in small animal practice in Switzerland for 2 years before entering a radiology residency program at the University of Bern.
She became board certified in radiology by the European College of Veterinary
Diagnostic Imaging in 2001. After two years as a Lecturer in Radiology she
became an Assistant Professor of Radiology at the University of Pennsylvania in
2004 and completed board certification by the American College of Veterinary
Radiology in 2006. She joined the faculty at North Carolina State University in
2009 as Associate Professor in Diagnostic Imaging.
Diplomate, European College of Veterinary Diagnostic Imaging
Diplomate, American College of Veterinary Radiology
Spontaneous Animal Disease Models
Use of imaging methods to investigate tumor perfusion in dogs and cats. Information about blood supply of a tumor is important for characterization of tumor type and selection of optimal treatment methods and response to treatment. Tumors with a low oxygen supply for example respond poorly to radiation therapy. Cancer research in dogs and cats is relevant to human patients as well as the spontaneous nature and the size of the patient closely resembles cancer in people. One method to investigate tumor perfusion non-invasively is contrast-enhanced ultrasound. Ultrasound contrast media are stabilized gas-filled microbubbles that are small enough to pass through capillaries. Their highly elastic shells are compressed or resonated when activated by an ultrasound beam, and they consequently produce a strong signal which can be registered by the ultrasound transducer. Vasculature and tissue perfusion of a tumor can thus be assessed repeatedly and non-invasively. Contrast-enhanced ultrasound has already been established as a safe imaging method in dogs and cats for assessment of various organs. It has been shown to accurately distinguish benign from malignant liver nodules in dogs. Furthermore, ultrasound contrast media can be used as a carrier for substances used for chemotherapy or gene therapy. Application of a strong ultrasound pulse in a specific location can burst the microbubbles and release the integrated substance in the target tissue.