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Heather Shive, DVM, PhD, DACVP

Assistant Professor, Anatomic Pathology

Contact:

hrshive@ncsu.edu
Office: 919.513.6296

Dr. Heather R. Shive joined the Department of Population Health and Pathobiology, at the College of Veterinary Medicine, North Carolina State University, as an Assistant Professor of Pathology in February 2014. Dr. Shive is also the Associate Director of the Comparative Pathology Core for the NCSU Center for Human Health and the Environment. Previously, she was a staff scientist in the National Cancer Institute, National Institutes of Health, in Dr. Dennis Hickstein’s research group within the Experimental Transplantation and Immunology Branch.

Dr. Shive completed her undergraduate education in Biology at the University of Arizona and received her DVM from NCSU-CVM. She received residency training in Anatomic Pathology at Texas A&M University, achieved board certification in Anatomic Pathology, and completed her Ph.D. at the National Cancer Institute, National Institutes of Health, in cooperation with the University of Maryland.
Affiliations
American College of Veterinary Pathologists, American Veterinary Medical Association
Certifications
Diplomate, American College of Veterinary Pathologists
Genetics
Our research applies the zebrafish model (Danio rerio) to discover conserved molecular mechanisms that mediate carcinogenesis. Cancer is a genetic disease, initiated and driven by mutations in genes that disrupt normal cell functions and promote tumor initiation and progression. Because cancers develop a broad spectrum of genetic disruptions, it is often difficult to identify changes that contribute to tumor development.

The zebrafish model is a powerful tool for analyzing genetic contributors to cancer risk: zebrafish exhibit conserved genetic susceptibility to cancer, are highly amenable to genetic manipulation, and can be analyzed in large numbers. Using cancer-prone transgenic and mutant zebrafish lines, we aim to apply in vivo assays to identify and characterize specific genes that modulate key aspects of carcinogenesis. Our research will ultimately incorporate environmental and toxicologic factors that may act in synergy with genetic factors to influence cancer risk.

  • Histologic and immunohistochemical analysis of soft tissue sarcomas from brca2-mutant/tp53-mutant zebrafish are consistent with neural crest (Schwann cell) origin.White LA, Sexton JM, Shive HR. | Accepted for publication in Veterinary Pathology.
  • Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1.Solin SL, Shive HR, Woolard KD, Esner JJ, McGrail M. | Sci Rep. 2015 Sep 8;5:13745.
  • brca2 and tp53 collaborate in tumorigenesis in zebrafish. Shive HR, West RR, Embree LJ, Golden CD, Hickstein DD.  | PLoS One 2014 10.1371/journal.pone.0087177.
  • Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 4 confer increased replication and syncytium formation in vitro but not increased replication and pathogenicity in chickens and ducks.Kim SH, Xiao S, Shive H, Collins PL, Samal SK.  | PLoS One 2013 Jan;8(1):e50598.
  • Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency.Bauer TR Jr, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD. | Mol Ther. 2013 May;21(5):964-72.
  • Zebrafish models for human cancer. Shive HR.  | Veterinary Pathology 2012 Nov; doi: 10.1177/0300985812467471.
  • Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. | PLoS One 2012 Apr;7(4):e34927.
  • Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J. | J Proteome Res. 2012 Mar 2;11(3):1561-70.
  • Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9. Samuel AS, Subbiah M, Shive H, Collins PL, Samal SK.  | Vet Res. 2011 Feb 23;42(1):38.
  • brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu PP, Hickstein DD. | Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5.
  • Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever. Russell-Lodrigue KE, Andoh M, Poels MW, Shive HR, Weeks BR, Zhang GQ, Tersteeg C, Masegi T, Hotta A, Yamaguchi T, Fukushi H, Hirai K, McMurray DN, Samuel JE. | Infect Immun. 2009 Dec;77(12):5640-50.
  • T cells are essential for bacterial clearance and IFN-g, TNF-a, and B cells are crucial for disease development in Coxiella burnetii infection in mice. Andoh M, Zhang G, Russell-Lodigue KE, Shive HR, Weeks BR, Samuel JE. | Infect Immun. 2007 July 75(7):3245-3255.
  • Liposarcoma in the nasal cavity of a cow. Shive H, Mohammed F, Osterstock J, Porter B, Mansell J.  | Vet Pathol. 2006 Sep;43(5):793-7
  • Simultaneous development of vocal and physical object combinations by a Grey parrot (Psittacus erithacus):  bottle caps, lids, and labels. Pepperberg IM, Shive HR.  | J. Comp Psychol 2001 Dec 115(4):376-84.
  • Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 4 confer increased replication and syncytium formation in vitro but not increased replication and pathogenicity in chickens and ducks. | PLoS One 2013 Jan;8(1):e50598.
  • Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency.Bauer TR Jr, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD. | Mol Ther. 2013 May;21(5):964-72.
  • Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks.Kim SH, Xiao S, Shive H, Collins PL, Samal SK. | PLoS One 2012 Apr;7(4):e34927.
  • Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J. | J Proteome Res. 2012 Mar 2;11(3):1561-70.
  • brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu PP, Hickstein DD. | Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5.
  • Expression of KRASG12V in zebrafish gills induces hyperplasia and CXCL8-associated inflammation.Shive HR, West RR, Embree LJ, Sexton JM, Hickstein DD. | Zebrafish. 2015 Mar 23. doi:10.1089/zeb.2014.1038
  • Evaluation of the contributions of individual viral genes to newcastle disease virus virulence and pathogenesis.Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, Samal SK. | J Virol. 2014 Aug 1;88(15):8579-96.