Description: Gastrointestinal tissues exhibit remarkable physiologic renewal and potential for regeneration following injury, serving as excellent model systems for understanding adult stem cell function. Our lab is interested in understanding how changes to chromatin state influence functional outcomes in adult stem cells between self-renewal, differentiation, and “de-differentiation”/phenotypic plasticity. To do this, we utilize two model systems with distinct functional characteristics: the intestinal epithelium and the biliary epithelium. While the intestinal epithelium is rapidly proliferative throughout adult life, the biliary epithelium is largely quiescent unless damaged. Our broad approach is to compare regulation of stem cells in the intestine and biliary tree, both of which demonstrate remarkable cellular plasticity, using transgenic reporter mice, primary organoid cultures, and genomic analyses. The long-term goal is to advance our understanding of regulatory programs in rare stem cell populations in order to improve therapeutic modalities in the fields of regenerative medicine and oncology.
Location: RB101, CVM, NC State University
Time: Tuesday, November 21, 2017,12:15 PM – 1:15 PM