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Gang Li: Functional Studies in the Post GWAS Era

March 20 @ 4:00 pm - 5:00 pm

Speaker: Gang Li, PhD – Functional Studies in the Post GWAS Era
Assistant Professor of Medicine, University of Pittsburgh School of Medicine
Description:

Genome wide association studies (GWAS) have provided significant insight into complex diseases by identifying numerous disease-associated non-coding single nucleotide polymorphisms (SNPs). However, GWAS cannot distinguish functional SNPs (fSNPs) from other disease-associated SNPs that are in linkage disequilibrium (LD). To address this challenge, we developed a novel approach to bridge the gap between GWAS and biological mechanisms with a set of high throughput methodologies. We use SNP-seq (Single Nucleotide Polymorphism-Sequencing) to identify disease-associated fSNPs and FREP-MS (Flanking Restriction Enhanced DNA Pulldown-Mass Spectrometry) to characterize these fSNPs by identifying regulatory proteins that specifically bind to the fSNPs. To prove the feasibility, we applied this approach to a couple of disease-associated loci. The implication of using these functional data to build a disease-associated risk gene transcriptional regulation network (TRN) is discussed.

Location: Room 101, CVM, NC State University
Time: Wednesday, March 20, 2017, 4:00pm
Host: MBS


Details

Date:
March 20
Time:

4:00 pm - 5:00 pm
Event Category: