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Gang Li: Functional Studies in the Post GWAS Era

March 20 @ 4:00 pm - 5:00 pm

Speaker: Gang Li, PhD – Functional Studies in the Post GWAS Era
Assistant Professor of Medicine, University of Pittsburgh School of Medicine

Genome wide association studies (GWAS) have provided significant insight into complex diseases by identifying numerous disease-associated non-coding single nucleotide polymorphisms (SNPs). However, GWAS cannot distinguish functional SNPs (fSNPs) from other disease-associated SNPs that are in linkage disequilibrium (LD). To address this challenge, we developed a novel approach to bridge the gap between GWAS and biological mechanisms with a set of high throughput methodologies. We use SNP-seq (Single Nucleotide Polymorphism-Sequencing) to identify disease-associated fSNPs and FREP-MS (Flanking Restriction Enhanced DNA Pulldown-Mass Spectrometry) to characterize these fSNPs by identifying regulatory proteins that specifically bind to the fSNPs. To prove the feasibility, we applied this approach to a couple of disease-associated loci. The implication of using these functional data to build a disease-associated risk gene transcriptional regulation network (TRN) is discussed.

Location: Room 101, CVM, NC State University
Time: Wednesday, March 20, 2017, 4:00pm
Host: MBS


March 20

4:00 pm - 5:00 pm
Event Category: