Description: Oscillations in brain-wide electrical potentials reflect emergent network-level signals that mediate behavior. Cracking the code whereby these oscillations coordinate in time and space (spatiotemporal dynamics) to represent complex behaviors would provide fundamental insights into how the brain signals emotional pathology. Using machine learning, we discover a spatiotemporal dynamic network that predicts the emergence of depression-related behavioral dysfunction in mice subjected to chronic social defeat stress. Activity patterns in this network originate in prefrontal cortex and ventral striatum, relay through amygdala and ventral tegmental area, and converge in ventral hippocampus. This network is increased by acute threat, and it is also enhanced in three independent models of depression vulnerability. Finally, we demonstrate that this vulnerability network is biologically distinct from the networks that encode dysfunction after stress. Thus, these findings reveal a convergent mechanism through which depression vulnerability is mediated in the brain.
Location: RB101, CVM, NC State University
Time: Tuesday, December 12, 2017, 12:15 PM – 1:15 PM
Kafui Dzisara, PhD, MD, Associate Professor of Psychiatry and Behavioral Sciences, Duke University