Article in April 18 Veterinary Practice News
By Jessica Tremayne
A recent groundbreaking study of clinical, histological and immunological data of 22 cases of Pemphigus foliaceus, or PF, shows evidence that it can occur as an adverse drug reaction to the canine flea and tick preventive ProMeris.
PF is the most common spontaneously occurring autoimmune skin disease of dogs and typically displays as lesions on the face, nasal planum and ears. The reaction is rare but serious, says the study’s lead author, Thierry Olivry, DrVet, PhD, Dipl. ACVD, of North Carolina State University.
Ultimately, ProMeris Duo (Metaflumizone–amitraz ), which is also used for treating demodicosis, will be discontinued. The topical, marketed by Pfizer Animal Health, will be available while supplies last or until mid-September.
“ProMeris was one of the many products that Pfizer brought into its portfolio when we acquired Wyeth/Fort Dodge Animal Health,” says Jim Brick, director and team leader of U.S. marketing for Pfizer Inc.
“We have completed a thorough review and evaluation of the strategic fit into the Pfizer Animal Health portfolio, and have made the decision to discontinue the manufacture and sale of Promeris flea and tick control for dogs and cats.
“We notified our current customers of this decision in early April and will continue to fill their orders until Sept. 20, 2011, or while supplies last. We look forward to continuing to meet the needs of our customers with our evolving parasiticide portfolio.”
The study that gathered and presented the ProMeris findings was conducted by Dr. Olivry; Ursula Oberkirchner, resident; and pathologist Keith Linder, DVM, PhD, all of North Carolina State University.
Since ProMeris’ introduction to U.S. and European markets in 2007, veterinarians have reported this adverse reaction, but previous case studies failed to use a drug-reaction probability scale and therefore an ADR couldn’t be definitively identified.
Olivry says this examination of all parameters studied suggests that this ADR might represent the first instance of contact drug-triggered PF to be published in Veterinary Dermatology. The article was published in the March issue of the journal.
Posted April 18, 2011