CVM Inside – Laboratory Animal Resources
Getting Started in 4 Steps
The following are sequential steps taken to promote understanding of the process of how projects progress within LAR. Starting here and progressing in this order will assist investigators in understanding the collaborative process with LAR.
- Online Orientation to provide clarity when starting an animal-based research or teaching project at NCSU-CVM. A great review for established users.
- The orientation provides a basic regulatory framework, the function of the IACUC, who to contact for needed services, how to get access and a general overview of LAR policies.
- Successful completion is required for unsupervised access to LAR facilities.
- IACUC An approved Application for Vertebrate Animal Use (AVAU) is required for all research projects. AVAU writing assistance from LAR is coordinated by the LAR Study Coordinator using the Project Planning form. The IACUC office provides a wealth of information.
- (RMHC/ BUA) All hazardous substance studies must be described in the appropriate form(s) on your approved IACUC AVAU. In addition, a written Standard Operating Procedure (SOP) for handling hazards may be required if requested based on Institutional Biosafety Committee ( IBC) review.
- IACUC approval is based on animal welfare, and regulatory issues; not on LAR resources, staffing, or space allocation. It is NOT an automatic commitment for the proposed study to proceed. Project Planning is designed to schedule meetings that facilitate successful studies and coordination of LAR resources.
- Project Planning Form begins coordination assistance from different LAR areas for investigator projects. This service is most beneficial for new investigators or those orchestrating complex projects with new animal models. Early contact after the grant writing phase is strongly advised.
- This form is designed to schedule meetings that coordinate the LAR Facility Manager, LAR Veterinary Services Supervisor, and LAR Study Coordinator, Veterinarians, and the Administrative Office as needed.
- LAR Access Request Form is required in order to grant access to animal housing and study areas. Successful completion of the orientation and a facility tour is required for access.
- LAR Animal Request Form is required to specifically commit funds for animals to be ordered and housing space to be reserved.
- Investigator Assistance Program provides skilled veterinary technicians and certified animal care technicians that support investigators and research staff. We offer veterinary or technical/husbandry assistance (hourly fee-for-service) or training (no charge). All individuals who handle or perform animal manipulations must be qualified, and listed on the IACUC protocol. When technical/ husbandry and veterinary services overlap, please submit a Veterinary Service Request Form.
- Central Procedures Laboratory (CPL) is a fully equipped experimental surgery unit with operating rooms for small and large animal surgery, associated support areas, and offers flexible space rooms for special procedures. A Veterinary Service Request form is required to reserve space with CPL and its package of associates services and supplies.
- Coordinating the availability of investigators, research animals, and resources in CPL can be challenging. Advance planning overcomes many of these challenges.
Basic Investigator Information
The following are key details essential to successful collaborations with LAR. These points are basic and apply to all researchers regardless of species or project type.
- There are no mark-ups on LAR charges. All costs are based on detailed cost accounting data thoroughly reviewed and approved by NC State Contracts and Grants Department.
- Per diem rates are charges for housing that vary by species, housing system, and housing density.
- Surgical cost center rates are for a package of services provided by CPL. Please see the current rate schedule for these costs and hourly fee-for-service costs associated with the Investigators Assistance program.
- See Veterinary Care Services policy for additional details.
- Housing availability is limited based on the complex dance of requested animal numbers, space and husbandry requirements (found in the applicable regulatory standards based on species), biosafety requirements ( provided by Environmental Health and Safety), individual investigator project needs, and staffing and facility constraints. LAR strives to provide clarity, efficiency, and cost-effective solutions as we balance these often complex needs.
- Supplies used in the care of and normal course of business with research animals are often part of the per-diem cost. This cost is shared among investigators equally. Any project that consumes supplies beyond this baseline cost will be charged directly to not artificially increase the cost for others.
- Alcohol is not a high-level sterilant or disinfectant. The current disinfectant provided by LAR has been approved for the associated risks in the environment.
- LAR provides veterinary care for all research and teaching animals housed in LAR 24 hrs per day, 7 days per week. Emergency contact information is posted in the facility and on the contact us section of the website. All animals are observed daily and signs of illness or injury are reported to veterinary staff.
- Investigators must also report sick animals that are not expected or associated with research manipulations. Adequate veterinary care must be provided which may include observation, treatment, or euthanasia.
- Initial veterinary care up to preliminary diagnosis is included in the per-diem cost. Subsequent treatments and case recehcks are charged based on the investigation assistance program ” hourly rate” fee schedule.
- IACUC protocol humane endpoints, animal welfare, or diseases requiring treatments that will interfere with research aims may prompt investigators to elect euthanasia of research animals. For these circumstances, the cost of euthanasia is included in per-diem costs.