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Research Lab – Department of Clinical Sciences 

Gastrointestinal Physiology

Lab Contact:    919.513.7725

The Gastrointestinal Physiology Laboratory studies mechanisms responsible for maintenance and restoration of the intestinal barrier, with the ultimate objective of pharmacologically restoring the mucosal barrier in patients suffering from diseases associated with increased intestinal permeability. Restoring the intestinal barrier would be of particular significance in patients suffering from diseases such as intestinal ischemia/reperfusion injury and gastric ulcer disease because of potential for severe medical complications such as sepsis that can occur with these diseases .

The laboratory collaborates extensively with the Leukocyte Biology Laboratory and the Center for Gastrointestinal Biology and Disease at UNC-Chapel Hill.

NC State CVM gastrointestinal lab member in blow up model of an intestine

Blikslager Lab

Ongoing Research

Development of a porcine model of esophageal injury and repair

NC State CVM Identification of stem, progenitor, and transit amplifying cells in porcine small intestine and colon.

“My research interests are in the development and characterization of a porcine model of esophageal injury and repair. We hope to elucidate underlying mechanisms and pathways in esophageal injury so we might better understand disorders such as Barrett’s Esophagus in humans, which is caused by continuous low-grade injury to the esophagus and can progress to more serious diseases such as esophageal adenocarcinoma.” – Leandi Kruger

“ I have two current research focuses. The first area of my research is the mechanisms underlying regulation of tight junctions in intestinal hypoxic injury and repair. Secondly, I am interested in examining the role of lubiprostone, a ClC-2 activator, in an experimental mouse model of colitis, and also hypoxic injury in an in vitro model utilizing a human colon cell line.” – Youngeeon Jin

The Role of ClC-2 in Intestinal Development and Repair

The central hypothesis for these studies is that the secretory protein ClC-2 recruits tight junction proteins to the apical lateral membrane, restoring intestinal barrier function.

NC State CVM The Role of ClC-2 in Intestinal Development and Repair

 

“I am broadly interested in immunology, the mechanisms that underlie infectious disease, and gastrointestinal physiology. I am currently working to develop a mouse model in which symptoms of human Irritable Bowel Syndrome (IBS) can be replicated and examined collectively by comparing post-infectious and post-inflammatory models for their ability to induce two major problematic symptoms that IBS patients experience, intestinal motility dysfunction and visceral hypersensitivity. Once a model is selected, I’ll evaluate histopathological changes and investigate additional symptoms such as alterations in intestinal permeability and secretion. The ultimate goal of this project is to identify causal genetic links that contribute to the development of IBS using the Collaborative Cross genetic reference panel.” – Shante Bryant

 

Education

The lab offers graduate training through the Comparative Biomedical Sciences program. CBS is a multidisciplinary graduate program with faculty who are employing state-of-the-art techniques to address a number of interesting scientific problems in the basic and applied biomedical sciences. The Comparative Biomedical Sciences Graduate Program is offered through the College of Veterinary Medicine at North Carolina State University and confers Master of Science (M.S.) and Doctor of Philosophy (Ph.D.) degrees. In addition, the laboratory participates in the Center for Comparative Medicine and Translational Research via the Mucosal Pathophysiology Core. We also collaborate with the Center for Biology and Gastrointestinal Disease, an NIH-funded Center linking GI researchers at UNC and NCSU.

  • The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivoMarshall JF, Bhatnagar AS, Bowman SG, Morris NN, Skorich DA, Redding CD, Blikslager AT | Equine Vet J Suppl 2011 Aug;(39):106-11. doi: 10.1111/j.2042-3306.2011.00401.x. PubMed PMID: 21790763
  • Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusionGrosche A, Morton AJ, Graham AS, Sanchez LC, Blikslager AT, Polyak MM, Freeman DE | Equine Vet J Suppl 2011 Aug;(39):8-15. doi: 10.1111/j.2042-3306.2011.00402.x. PubMed PMID: 21790749
  • Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horsesMarshall JF, Bhatnagar AS, Bowman SG, Howard CM, Morris NN, Skorich DA, Redding CD, Blikslager AT | Am J Vet Res 2011 Feb;72(2):226-32. doi: 10.2460/ajvr.72.2.226. PubMed PMID: 21281197
  • The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horsesDavis JL, Marshall JF, Papich MG, Blikslager AT, Campbell NB | J Vet Pharmacol Ther 2011 Feb;34(1):12-6. doi: 10.1111/j.1365-2885.2010.01185.x. PubMed PMID: 21219338
  • OBEBlikslager A, Christley R, Jeffcott L, Silver I, van Weeren R. Dr Peter Rossdale | Editor Equine Veterinary Journal 1980-2010. Equine Vet J. 2011 Jan;43(1):2. doi: 10.1111/j.2042-3306.2010.00347.x. PubMed PMID: 21143626
  • TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epitheliumKajino-Sakamoto R, Omori E, Nighot PK, Blikslager AT, Matsumoto K, Ninomiya-Tsuji J | J Immunol 2010 Oct 15;185(8):4729-37. doi: 0.4049/jimmunol.0903587. Epub 2010 Sep 20. PubMed PMID: 20855879; PubMed Central PMCID: PMC3064262
  • A surgical tendonitis model in horses: technique, clinical, ultrasonographic and histological characterisationSchramme M, Hunter S, Campbell N, Blikslager A, Smith R | Vet Comp Orthop Traumatol 2010;23(4):231-9. doi: 10.3415/VCOT-09-10-0106. Epub 2010 Jun 21. PubMed PMID: 20585715
  • Demographic characteristics of horses donated to the North Carolina State University Equine Health CenterBowman SG, Marshall JF, Blikslager AT | 1996-2008. J Am Vet Med Assoc 2010 Jun 15;236(12):1334-7. doi: 10.2460/javma.236.12.1334. PubMed PMID: 20550449
  • Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogsWooten JG, Lascelles BD, Cook VL, Law JM, Blikslager AT | Am J Vet Res 2010 Jun;71(6):630-5. doi:10.2460/ajvr.71.6.630. PubMed PMID: 20513177
  • ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junctionNighot PK, Blikslager AT | Am J Physiol Gastrointest Liver Physiol 2010 Aug;299(2):G449-56. doi: 10.1152/ajpgi.00520.2009. Epub 2010 May 20. PubMed PMID: 20489043
  • Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expressionNighot PK, Moeser A, Ali RA, Blikslager AT, Koci MD | Virology 2010 Jun 5;401(2):146-54. doi: 10.1016/j.virol.2010.02.004. Epub 2010 Mar 12. PubMed PMID: 20219227; PubMed Central PMCID: PMC2862094
  • Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulusSheats MK, Cook VL, Jones SL, Blikslager AT, Pease AP | Equine Vet J 2010 Jan;42(1):47-52. doi: 10.2746/042516409X456040. PubMed PMID: 20121913
  • Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horsesMorton AJ, Grosche A, Rötting AK, Matyjaszek SA, Blikslager AT, Freeman DE | Am J Vet Res 2009 Dec;70(12):1536-44. doi: 10.2460/ajvr.70.12.1536. PubMed PMID: 19951126
  • Early weaning stress impairs development of mucosal barrier function in the porcine intestineSmith F, Clark JE, Overman BL, Tozel CC, Huang JH, Rivier JE, Blikslager AT, Moeser AJ | Am J Physiol Gastrointest Liver Physiol 2010 Mar;298(3):G352-63. doi: 10.1152/ajpgi.00081.2009. Epub 2009 Nov 19. PubMed PMID: 19926814; PubMed Central PMCID: PMC2838512
  • Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horsesCook VL, Jones Shults J, McDowell MR, Campbell NB, Davis JL, Marshall JF, Blikslager AT | Am J Vet Res 2009 Oct;70(10):1259-68. doi: 10.2460/ajvr.70.10.1259. PubMed PMID: 19795941
  • Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogsWooten JG, Blikslager AT, Marks SL, Law JM, Graeber EC, Lascelles BD | Am J Vet Res 2009 Oct;70(10):1243-9. doi: 10.2460/ajvr.70.10.1243. PubMed PMID: 19795939
  • Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunumCook VL, Meyer CT, Campbell NB, Blikslager AT | Am J Vet Res 2009 Aug;70(8):992-1000. doi: 10.2460/ajvr.70.8.992. PubMed PMID: 19645580
  • The effect of lidocaine on in vitro adhesion and migration of equine neutrophils.Cook VL, Neuder LE, Blikslager AT, Jones SL | Vet Immunol Immunopathol Vet Immunol Immunopathol
  • Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal diseaseFogle CA, Gerard MP, Elce YA, Little D, Morton AJ, Correa MT, Blikslager AT | Vet Surg 2008 Aug;37(6):558-63. doi: 10.1111/j.1532-950X.2008.00420.x. PubMed PMID: 19134106
  • ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunumNighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT | Exp Cell Res 2009 Jan 1;315(1):110-8. doi: 10.1016/j.yexcr.2008.10.001. Epub 2008 Oct 17. PubMed PMID: 18976652
  • Enrichment of intestinal mucosal phospholipids with arachidonic and eicosapentaenoic acids fed to suckling piglets is dose and time dependentHess HA, Corl BA, Lin X, Jacobi SK, Harrell RJ, Blikslager AT, Odle J | J Nutr 2008 Nov;138(11):2164-71. doi: 10.3945/jn.108.094136. PubMed PMID: 18936214
  • Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestineMoeser AJ, Nighot PK, Roerig B, Ueno R, Blikslager AT | World J Gastroenterol 2008 Oct 21;14(39):6012-7. PubMed PMID: 18932279; PubMed Central PMCID: PMC2760184
  • Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier functionMoeser AJ, Nighot PK, Ryan KA, Simpson JE, Clarke LL, Blikslager AT | Am J Physiol Gastrointest Liver Physiol 2008 Oct;295(4):G791-7. doi: 10.1152/ajpgi.00538.2007. Epub 2008 Aug 21. PubMed PMID: 18719001
  • Post operative ileus: to be or not to be?Merritt AM, Blikslager AT | Equine Vet J Equine Vet J
  • Use of systemically administered lidocaine in horses with gastrointestinal tract diseaseCook VL, Blikslager AT | J Am Vet Med Assoc 2008 Apr 15;232(8):1144-8. doi: 10.2460/javma.232.8.1144. Review. PubMed PMID: 18412523
  • Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaineCook VL, Jones Shults J, McDowell M, Campbell NB, Davis JL, Blikslager AT | Equine Vet J 2008 Jun;40(4):353-7. doi: 10.2746/042516408X293574. PubMed PMID: 18321812
  • Life in the gut without oxygen: adaptive mechanisms and inflammatory bowel diseaseBlikslager AT | Gastroenterology 2008 Jan;134(1):346-8. doi: 10.1053/j.gastro.2007.11.049. PubMed PMID: 18166362
  • Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritisCorl BA, Odle J, Niu X, Moeser AJ, Gatlin LA, Phillips OT, Blikslager AT, Rhoads JM | J Nutr 2008 Jan;138(1):24-9. PubMed PMID: 18156399
  • Mechanisms of porcine diarrheal diseaseMoeser AJ, Blikslager AT | J Am Vet Med Assoc 2007 Jul 1;231(1):56-67. Review. PubMed PMID: 17605665
  • Determination of minimum alveolar concentration of sevoflurane in juvenile swineMoeser AJ, Blikslager AT, Swanson C | Res Vet Sci 2008 Apr;84(2):283-5. Epub 2007 Jun 13. PubMed PMID: 17570452
  • Cyclooxygenase (COX) inhibitors and the intestineLittle D, Jones SL, Blikslager AT | J Vet Intern Med 2007 May-Jun;21(3):367-77. Review. PubMed PMID: 17552439
  • Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunumLittle D, Brown SA, Campbell NB, Moeser AJ, Davis JL, Blikslager AT | Am J Vet Res 2007 Jun;68(6):614-24. PubMed PMID: 17542694
  • Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigsMoeser AJ, Ryan KA, Nighot PK, Blikslager AT | Am J Physiol Gastrointest Liver Physiol 2007 Aug;293(2):G413-21. Epub 2007 May 24. PubMed PMID: 17525151
  • Restoration of barrier function in injured intestinal mucosaBlikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J | Physiol Rev 2007 Apr;87(2):545-64. Review. PubMed PMID: 17429041
  • Pharmacokinetics of etodolac in the horse following oral and intravenous administrationDavis JL, Papich MG, Morton AJ, Gayle J, Blikslager AT, Campbell NB | J Vet Pharmacol Ther 2007 Feb;30(1):43-8. PubMed PMID: 17217400
  • Inflamm Bowel DisNighot P, Young K, Nighot M, Rawat M, Sung EJ, Maharshak N, Plevy SE, Ma T, Blikslager A | 2013 Sep 11.[Epub ahead of print] PMID:24030525
  • World J GastroenterolJacobi SK, Moeser AJ, Blikslager AT, Rhoads JM, Corl BA, Harrell RJ, Odle J | 2013 Aug 21;19(31):5094-102. doi: 10.3748/wjg.v19.i31.5094. PMID:23964143
  • Feeding intravenously saves the patient but starves the gutBlikslager AT | J Physiol 2013 Aug 1;591(Pt 15):3673. doi: 10.1113/jphysiol.2013.260703. No abstract available. PMID:23908408
  • PLoS OneGonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST | 2013 Jun 28;8(6):e66465. doi: 10.1371/journal.pone.0066465. Print 2013.PMID: 23840480
  • Validation of a photogrammetric technique for computing equine hoof volumeLabens R, Redding WR, Desai KK, Vom Orde K, Mansmann RA, Blikslager AT | Vet J 2013 May 9. doi:pii: S1090-0233(13)00176-7. 10.1016/j.tvjl.2013.04.005. [Epub ahead of print] PubMed PMID: 23664155
  • Misoprostol: is it safety or a lack of understanding that prevents its more frequent usage?Blikslager AT | Equine Vet J 2013 Jan;45(1):8. doi: 10.1111/evj.12017. PubMed PMID: 23231384
  • Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosaNighot M, Moeser A, Ueno R, Blikslager A | World J Gastroenterol 2012 Sep 14;18(34):4684-92. PubMed PMID: 23002337; PubMed Central PMCID: PMC3442206
  • Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010)Davis W, Fogle CA, Gerard MP, Levine JF, Blikslager AT | Equine Vet J 2013 Mar;45(2):224-8. doi: 10.1111/j.2042-3306.2012.00615.x. Epub 2012 Aug 1. PubMed PMID: 22853644
  • Dietary long-chain PUFA enhance acute repair of ischemia-injured intestine of suckling pigsJacobi SK, Moeser AJ, Corl BA, Harrell RJ, Blikslager AT, Odle J | J Nutr. 2012 Jul;142(7):1266-71. doi: 10.3945/jn.111.150995. Epub 2012 May 23. PubMed PMID: 22623387
  • Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressorsCuppoletti J, Blikslager AT, Chakrabarti J, Nighot PK, Malinowska DH | BMC Pharmacol 2012 May 3;12:3. doi: 10.1186/1471-2210-12-3. PubMed PMID: 22553939; PubMed Central PMCID: PMC3403872
  • Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivoHill TL, Blikslager AT | Am J Vet Res 2012 May;73(5):659-63. doi: 10.2460/ajvr.73.5.659. PubMed PMID: 22533397
  • Precision of a photogrammetric method to perform 3D wound measurements compared to standard 2D photographic techniques in the horseLabens R, Blikslager A | Equine Vet J 2013 Jan;45(1):41-6. doi: 10.1111/j.2042-3306.2011.00538.x. Epub 2012 Jan 28. PubMed PMID: 22283145
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infectionMeyerhoff RR, Nighot PK, Ali RA, Blikslager AT, Koci MD | Comp Immunol Microbiol Infect Dis 2012 Jan;35(1):63-9. doi: 10.1016/j.cimid.2011.10.001. Epub 2011 Nov 25. PubMed PMID: 22118854; PubMed Central PMCID: PMC3253919
  • Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludinNighot PK, Blikslager AT | Am J Physiol Cell Physiol 2012 Jan 1;302(1):C178-87. doi: 10.1152/ajpcell.00072.2011. Epub 2011 Sep 28. PubMed PMID: 21956164
  • Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigsMessenger KM, Papich MG, Blikslager AT | J Vet Pharmacol Ther 2012 Oct;35(5):452-9. doi: 10.1111/j.1365-2885.2011.01338.x. Epub 2011 Sep 14. PubMed PMID: 21913941
  • The effect of nonsteroidal anti-inflammatory drugs on the equine intestineMarshall JF, Blikslager AT | Equine Vet J Suppl 2011 Aug;(39):140-4. doi: 10.1111/j.2042-3306.2011.00398.x. Review. PubMed PMID: 21790769
  • ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunumNighot PK, Moeser AJ, Ryan KA, Ghashghaei T, Blikslager AT | Exp Cell Res 2009 Jan 1;315(1):110-8. doi: 10.1016/j.yexcr.2008.10.001. Epub 2008 Oct 17. PubMed PMID: 18976652
  • Enrichment of intestinal mucosal phospholipids with arachidonic and eicosapentaenoic acids fed to suckling piglets is dose and time dependentHess HA, Corl BA, Lin X, Jacobi SK, Harrell RJ, Blikslager AT, Odle J | J Nutr 2008 Nov;138(11):2164-71. doi: 10.3945/jn.108.094136. PubMed PMID: 18936214
  • Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestineMoeser AJ, Nighot PK, Roerig B, Ueno R, Blikslager AT | World J Gastroenterol 2008 Oct 21;14(39):6012-7. PubMed PMID: 18932279; PubMed Central PMCID: PMC2760184
  • Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier functionMoeser AJ, Nighot PK, Ryan KA, Simpson JE, Clarke LL, Blikslager AT | Am J Physiol Gastrointest Liver Physiol 2008 Oct;295(4):G791-7. doi: 10.1152/ajpgi.00538.2007. Epub 2008 Aug 21. PubMed PMID: 18719001
  • Post operative ileus: to be or not to be?Merritt AM, Blikslager AT | Equine Vet J Equine Vet J
  • Use of systemically administered lidocaine in horses with gastrointestinal tract diseaseCook VL, Blikslager AT | J Am Vet Med Assoc 2008 Apr 15;232(8):1144-8. doi: 10.2460/javma.232.8.1144. Review. PubMed PMID: 18412523
  • Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaineCook VL, Jones Shults J, McDowell M, Campbell NB, Davis JL, Blikslager AT | Equine Vet J 2008 Jun;40(4):353-7. doi: 10.2746/042516408X293574. PubMed PMID: 18321812
  • Life in the gut without oxygen: adaptive mechanisms and inflammatory bowel diseaseBlikslager AT | Gastroenterology 2008 Jan;134(1):346-8. doi: 10.1053/j.gastro.2007.11.049. PubMed PMID: 18166362
  • Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritisCorl BA, Odle J, Niu X, Moeser AJ, Gatlin LA, Phillips OT, Blikslager AT, Rhoads JM | J Nutr 2008 Jan;138(1):24-9. PubMed PMID: 18156399
  • Mechanisms of porcine diarrheal diseaseMoeser AJ, Blikslager AT | J Am Vet Med Assoc 2007 Jul 1;231(1):56-67. Review. PubMed PMID: 17605665
  • Determination of minimum alveolar concentration of sevoflurane in juvenile swineMoeser AJ, Blikslager AT, Swanson C | Res Vet Sci 2008 Apr;84(2):283-5. Epub 2007 Jun 13. PubMed PMID: 17570452
  • Cyclooxygenase (COX) inhibitors and the intestineLittle D, Jones SL, Blikslager AT | J Vet Intern Med 2007 May-Jun;21(3):367-77. Review. PubMed PMID: 17552439
  • Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunumLittle D, Brown SA, Campbell NB, Moeser AJ, Davis JL, Blikslager AT | Am J Vet Res 2007 Jun;68(6):614-24. PubMed PMID: 17542694
  • Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigsMoeser AJ, Ryan KA, Nighot PK, Blikslager AT | Am J Physiol Gastrointest Liver Physiol 2007 Aug;293(2):G413-21. Epub 2007 May 24. PubMed PMID: 17525151
  • Restoration of barrier function in injured intestinal mucosaBlikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J | Physiol Rev 2007 Apr;87(2):545-64. Review. PubMed PMID: 17429041
  • Pharmacokinetics of etodolac in the horse following oral and intravenous administrationDavis JL, Papich MG, Morton AJ, Gayle J, Blikslager AT, Campbell NB | J Vet Pharmacol Ther 2007 Feb;30(1):43-8. PubMed PMID: 17217400
  • Inflamm Bowel DisNighot P, Young K, Nighot M, Rawat M, Sung EJ, Maharshak N, Plevy SE, Ma T, Blikslager A | 2013 Sep 11.[Epub ahead of print] PMID:24030525
  • World J GastroenterolJacobi SK, Moeser AJ, Blikslager AT, Rhoads JM, Corl BA, Harrell RJ, Odle J | 2013 Aug 21;19(31):5094-102. doi: 10.3748/wjg.v19.i31.5094. PMID:23964143
  • Feeding intravenously saves the patient but starves the gutBlikslager AT | J Physiol 2013 Aug 1;591(Pt 15):3673. doi: 10.1113/jphysiol.2013.260703. No abstract available. PMID:23908408
  • PLoS OneGonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST | 2013 Jun 28;8(6):e66465. doi: 10.1371/journal.pone.0066465. Print 2013.PMID: 23840480
  • Validation of a photogrammetric technique for computing equine hoof volumeLabens R, Redding WR, Desai KK, Vom Orde K, Mansmann RA, Blikslager AT | Vet J 2013 May 9. doi:pii: S1090-0233(13)00176-7. 10.1016/j.tvjl.2013.04.005. [Epub ahead of print] PubMed PMID: 23664155
  • Misoprostol: is it safety or a lack of understanding that prevents its more frequent usage?Blikslager AT | Equine Vet J 2013 Jan;45(1):8. doi: 10.1111/evj.12017. PubMed PMID: 23231384
  • Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosaNighot M, Moeser A, Ueno R, Blikslager A | World J Gastroenterol 2012 Sep 14;18(34):4684-92. PubMed PMID: 23002337; PubMed Central PMCID: PMC3442206
  • Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010)Davis W, Fogle CA, Gerard MP, Levine JF, Blikslager AT | Equine Vet J 2013 Mar;45(2):224-8. doi: 10.1111/j.2042-3306.2012.00615.x. Epub 2012 Aug 1. PubMed PMID: 22853644
  • Dietary long-chain PUFA enhance acute repair of ischemia-injured intestine of suckling pigsJacobi SK, Moeser AJ, Corl BA, Harrell RJ, Blikslager AT, Odle J | J Nutr. 2012 Jul;142(7):1266-71. doi: 10.3945/jn.111.150995. Epub 2012 May 23. PubMed PMID: 22623387
  • Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressorsCuppoletti J, Blikslager AT, Chakrabarti J, Nighot PK, Malinowska DH | BMC Pharmacol 2012 May 3;12:3. doi: 10.1186/1471-2210-12-3. PubMed PMID: 22553939; PubMed Central PMCID: PMC3403872
  • Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivoHill TL, Blikslager AT | Am J Vet Res 2012 May;73(5):659-63. doi: 10.2460/ajvr.73.5.659. PubMed PMID: 22533397
  • Precision of a photogrammetric method to perform 3D wound measurements compared to standard 2D photographic techniques in the horseLabens R, Blikslager A | Equine Vet J 2013 Jan;45(1):41-6. doi: 10.1111/j.2042-3306.2011.00538.x. Epub 2012 Jan 28. PubMed PMID: 22283145
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infectionMeyerhoff RR, Nighot PK, Ali RA, Blikslager AT, Koci MD | Comp Immunol Microbiol Infect Dis 2012 Jan;35(1):63-9. doi: 10.1016/j.cimid.2011.10.001. Epub 2011 Nov 25. PubMed PMID: 22118854; PubMed Central PMCID: PMC3253919
  • Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludinNighot PK, Blikslager AT | Am J Physiol Cell Physiol 2012 Jan 1;302(1):C178-87. doi: 10.1152/ajpcell.00072.2011. Epub 2011 Sep 28. PubMed PMID: 21956164
  • Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigsMessenger KM, Papich MG, Blikslager AT | J Vet Pharmacol Ther 2012 Oct;35(5):452-9. doi: 10.1111/j.1365-2885.2011.01338.x. Epub 2011 Sep 14. PubMed PMID: 21913941
  • The effect of nonsteroidal anti-inflammatory drugs on the equine intestineMarshall JF, Blikslager AT | Equine Vet J Suppl 2011 Aug;(39):140-4. doi: 10.1111/j.2042-3306.2011.00398.x. Review. PubMed PMID: 21790769
  • The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivoMarshall JF, Bhatnagar AS, Bowman SG, Morris NN, Skorich DA, Redding CD, Blikslager AT | Equine Vet J Suppl 2011 Aug;(39):106-11. doi: 10.1111/j.2042-3306.2011.00401.x. PubMed PMID: 21790763
  • Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusionGrosche A, Morton AJ, Graham AS, Sanchez LC, Blikslager AT, Polyak MM, Freeman DE | Equine Vet J Suppl 2011 Aug;(39):8-15. doi: 10.1111/j.2042-3306.2011.00402.x. PubMed PMID: 21790749
  • Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horsesMarshall JF, Bhatnagar AS, Bowman SG, Howard CM, Morris NN, Skorich DA, Redding CD, Blikslager AT | Am J Vet Res 2011 Feb;72(2):226-32. doi: 10.2460/ajvr.72.2.226. PubMed PMID: 21281197
  • The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horsesDavis JL, Marshall JF, Papich MG, Blikslager AT, Campbell NB | J Vet Pharmacol Ther 2011 Feb;34(1):12-6. doi: 10.1111/j.1365-2885.2010.01185.x. PubMed PMID: 21219338
  • OBEBlikslager A, Christley R, Jeffcott L, Silver I, van Weeren R. Dr Peter Rossdale | Editor Equine Veterinary Journal 1980-2010. Equine Vet J. 2011 Jan;43(1):2. doi: 10.1111/j.2042-3306.2010.00347.x. PubMed PMID: 21143626
  • TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epitheliumKajino-Sakamoto R, Omori E, Nighot PK, Blikslager AT, Matsumoto K, Ninomiya-Tsuji J | J Immunol 2010 Oct 15;185(8):4729-37. doi: 0.4049/jimmunol.0903587. Epub 2010 Sep 20. PubMed PMID: 20855879; PubMed Central PMCID: PMC3064262
  • A surgical tendonitis model in horses: technique, clinical, ultrasonographic and histological characterisationSchramme M, Hunter S, Campbell N, Blikslager A, Smith R | Vet Comp Orthop Traumatol 2010;23(4):231-9. doi: 10.3415/VCOT-09-10-0106. Epub 2010 Jun 21. PubMed PMID: 20585715
  • Demographic characteristics of horses donated to the North Carolina State University Equine Health CenterBowman SG, Marshall JF, Blikslager AT | 1996-2008. J Am Vet Med Assoc 2010 Jun 15;236(12):1334-7. doi: 10.2460/javma.236.12.1334. PubMed PMID: 20550449
  • Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogsWooten JG, Lascelles BD, Cook VL, Law JM, Blikslager AT | Am J Vet Res 2010 Jun;71(6):630-5. doi:10.2460/ajvr.71.6.630. PubMed PMID: 20513177
  • ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junctionNighot PK, Blikslager AT | Am J Physiol Gastrointest Liver Physiol 2010 Aug;299(2):G449-56. doi: 10.1152/ajpgi.00520.2009. Epub 2010 May 20. PubMed PMID: 20489043
  • Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expressionNighot PK, Moeser A, Ali RA, Blikslager AT, Koci MD | Virology 2010 Jun 5;401(2):146-54. doi: 10.1016/j.virol.2010.02.004. Epub 2010 Mar 12. PubMed PMID: 20219227; PubMed Central PMCID: PMC2862094
  • Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulusSheats MK, Cook VL, Jones SL, Blikslager AT, Pease AP | Equine Vet J 2010 Jan;42(1):47-52. doi: 10.2746/042516409X456040. PubMed PMID: 20121913
  • Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses | Am J Vet Res 2009 Dec;70(12):1536-44. doi: 10.2460/ajvr.70.12.1536. PubMed PMID: 19951126
  • Early weaning stress impairs development of mucosal barrier function in the porcine intestineSmith F, Clark JE, Overman BL, Tozel CC, Huang JH, Rivier JE, Blikslager AT, Moeser AJ | Am J Physiol Gastrointest Liver Physiol 2010 Mar;298(3):G352-63. doi: 10.1152/ajpgi.00081.2009. Epub 2009 Nov 19. PubMed PMID: 19926814; PubMed Central PMCID: PMC2838512
  • Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horsesCook VL, Jones Shults J, McDowell MR, Campbell NB, Davis JL, Marshall JF, Blikslager AT | Am J Vet Res 2009 Oct;70(10):1259-68. doi: 10.2460/ajvr.70.10.1259. PubMed PMID: 19795941
  • Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogsWooten JG, Blikslager AT, Marks SL, Law JM, Graeber EC, Lascelles BD | Am J Vet Res 2009 Oct;70(10):1243-9. doi: 10.2460/ajvr.70.10.1243. PubMed PMID: 19795939
  • Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunumCook VL, Meyer CT, Campbell NB, Blikslager AT | Am J Vet Res 2009 Aug;70(8):992-1000. doi: 10.2460/ajvr.70.8.992. PubMed PMID: 19645580
  • The effect of lidocaine on in vitro adhesion and migration of equine neutrophils.Cook VL, Neuder LE, Blikslager AT, Jones SL | Vet Immunol Immunopathol Vet Immunol Immunopathol
  • Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal diseaseFogle CA, Gerard MP, Elce YA, Little D, Morton AJ, Correa MT, Blikslager AT | Vet Surg 2008 Aug;37(6):558-63. doi: 10.1111/j.1532-950X.2008.00420.x. PubMed PMID: 19134106
  • (2008) Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugsWooten JG, Blikslager AT, Ryan KA, Marks SL, Law M, Lascelles BDX | American Journal of Veterinary Research 2008;69(4):457-464
  • (2007) Performance of the 808-nm diode laser on equine upper airway tissue is enhanced by intravenous administration of indocyanine green.Tate LP, Blikslager AT, Papich MG. | Photomed Laser Surg. 2007 Oct;25(5):443-8. PMID: 17975959.
  • (2007) Drug Interactions (Chapter 16).Papich MG. | In: Tranquilli WJ, Thurmon JC, & Grimm KA (eds), Lumb & Jones’ Veterinary Anesthesia and Analgesia; Blackwell Publishing, Ames, Iowa, 2007, page 439-450.

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