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Center for Comparative Medicine and Translational Research

Research Core: Stem Cells and Regenerative Medicine

Researching the clinical applications of stem cells in regenerative medicine. Areas of focus include development and characterization of induced pluripotential stem cells, stem cells and cancer, stem cells and spinal cord repair, and basic studies on transcriptional control of stem cell differentiation.

Specific areas of research include:

  • Targeted differentiation of ES cells and iPS into different tissue types.
  • Development of alternative large animal models for stem cell repair.
  • Effects of electrical and mechanical stimulation on stem cell fate.
  • Isolation and characterization of side populations from multiple cancer types.
  • Development of therapeutic strategies targeting cancer stem cells, including induced differentiation.

Regenerative Medicine is a term applied to new medical advances in which an understanding of the human genome (all the inheritable traits of an organism) allows us to use the body’s own mechanisms to heal it. Expected advances include a host of new pharmaceuticals and, eventually, the ability to create new tissues for transplant.

Core Leader

Dr. Jorge Piedrahita

CCMTR is collaborating with UNC’s School of Medicine in the area of regenerative medicine. Click here for information on the research, people and resources involved in this joint program. The two institutions recently held their first symposium: Symposium Encourages Collaborative Efforts in Regenerative Medicine.