Oncology

Aug 15, 2023

Now Enrolling Dogs with Invasive Urothelial Carcinoma

Principle Investigator Dr. Paul Hess Description NC State Veterinary Hospital is enrolling patients for a clinical trial of an experimental immunotherapy for the treatment of bladder cancer. The primary purpose of this study is to investigate the safety and immune-stimulating properties of a novel therapy being developed at NCSU. There will be multiple dosing groups during… 

Aug 3, 2023

Immunotherapy Clinical Trial for Patients with Oral Melanoma

Principal Investigator Dr. Michael Nolan Description NC State Veterinary Hospital is now recruiting dogs with oral malignant melanoma to evaluate the safety, tolerability, and efficacy of a novel immunotherapy. The immunotherapy is an antibody that aims to invigorate your dog’s immune system and help it eliminate cancer cells. Study Requirements Follow-up: After your screening appointment, you… 

Jul 18, 2023

Now Enrolling Canine Patients with Liver Tumors

Principle Investigator Dr. Kyle Mathews Description Does your dog have a liver tumor? We are now enrolling canine patients that have a liver tumor into a clinical trial that is using a new therapy called INSPIRE, which uses electrical pulses to safely destroy the cells within a tumor. This study has two treatment groups. One… 

Jan 31, 2023

Screening urine samples from high-risk dog breeds for early bladder cancer

Principal Investigator Dr Shelly Vaden Description This study is screening urine samples from clinically healthy dogs at increased risk of bladder cancer, to determine if they test positive for a genetic marker of the disease (a specific mutation in the dog BRAF gene). The goal is to determine whether this BRAF Mutation Detection test can… 

Jan 31, 2023

Therapeutic trials for canine bladder cancer

Principal Investigator Dr Shelly Vaden Description This study will investigate whether the administration of a dietary supplement slows the progression of canine bladder cancer (also known as transitional cell carcinoma/urothelial carcinoma, or TCC/UC) in dogs treated with standard of care therapy Testing Requirements Participants will be asked to: – bring their dog for an initial… 

Jan 19, 2023

Now Enrolling Dogs with Bladder Cancer

Principal Investigator Dr. Michael Mastromauro Description NC State University College of Veterinary Medicine is enrolling in a clinical trial to investigate if a probiotic can improve cancer care and outcomes in dogs with bladder cancer. This is a placebo-controlled study, not all dogs will receive the probiotic, but all dogs will receivechemotherapy (vinblastine/piroxicam). Testing Requirements Dogs… 

Dec 19, 2022

Treatment of feline lymphocytic lymphoma/inflammatory bowel disease complex (FLL/IBD): A novel approach for managing the cat who’s impossible to pill

Principal Investigator Tracy Gieger Description Cats referred to NC State for assessment of chronic GI disease are eligible for initial screening. Cats treated with steroids or chemotherapy and cats that have been on hypoallergenic diet trials starting within 30 days of referral will be excluded. Your cat must have had general heath screening bloodwork (CBC and… 

Dec 19, 2022

Phase 1 Dose Escalation of Single-Agent Mechlorethamine HCl in Dogs with Lymphoma

Principal Investigator Dr. Joanne Intile Description We are recruiting dogs with lymphoma to determine the optimal dose of a chemotherapy drug called mustargen. Enrolled dogs will receive one free dose of mustargen and undergo follow up blood work for up to two weeks afterwards. Dogs can then receive other chemotherapy drugs, either at NCSU CVM… 

Aug 3, 2022

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principal Investigator Kyle Mathews Description This study is looking for dogs with 1-2 discrete mammary tumors measuring between 1-3cm to participate in a clinical trial that is investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. Owners would need to bring their dog to… 

Aug 3, 2022

Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer 

Principal Investigator Dr Shelly Vaden Description This study will investigate: 1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs. 2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary…