Oncology

Jan 31, 2023

Screening urine samples from high-risk dog breeds for early bladder cancer

Principle Investigator Dr Shelly Vaden Description This study is screening urine samples from clinically healthy dogs at increased risk of bladder cancer, to determine if they test positive for a genetic marker of the disease (a specific mutation in the dog BRAF gene). The goal is to determine whether this BRAF Mutation Detection test can… 

Jan 31, 2023

Therapeutic trials for canine bladder cancer

Principle Investigator Dr Shelly Vaden Description This study will investigate whether the administration of a dietary supplement slows the progression of canine bladder cancer (also known as transitional cell carcinoma/urothelial carcinoma, or TCC/UC) in dogs treated with standard of care therapy Testing Requirements Participants will be asked to: – bring their dog for an initial… 

Jan 19, 2023

Now Enrolling Dogs with Bladder Cancer

Principle Investigator Dr. Michael Mastromauro Description NC State University College of Veterinary Medicine is enrolling in a clinical trial to investigate if a probiotic can improve cancer care and outcomes in dogs with bladder cancer. This is a placebo-controlled study, not all dogs will receive the probiotic, but all dogs will receivechemotherapy (vinblastine/piroxicam). Testing Requirements Dogs… 

Dec 19, 2022

Treatment of feline lymphocytic lymphoma/inflammatory bowel disease complex (FLL/IBD): A novel approach for managing the cat who’s impossible to pill

Principle Investigator Tracy Gieger Description Cats referred to NC State for assessment of chronic GI disease are eligible for initial screening. Cats treated with steroids or chemotherapy and cats that have been on hypoallergenic diet trials starting within 30 days of referral will be excluded. Your cat must have had general heath screening bloodwork (CBC and… 

Dec 19, 2022

Phase 1 Dose Escalation of Single-Agent Mechlorethamine HCl in Dogs with Lymphoma

Principle Investigator Dr. Joanne Intile Description We are recruiting dogs with lymphoma to determine the optimal dose of a chemotherapy drug called mustargen. Enrolled dogs will receive one free dose of mustargen and undergo follow up blood work for up to two weeks afterwards. Dogs can then receive other chemotherapy drugs, either at NCSU CVM… 

Aug 3, 2022

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principle Investigator Kyle Mathews Description Dogs with mammary tumors are eligible for a clinical trial investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. A week after INSPIRE therapy, your dog will be readmitted to the NC State surgical service to undergo a mastectomy for… 

Aug 3, 2022

Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer 

Principle Investigator Dr Shelly Vaden Description This study will investigate: 1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs. 2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary… 

Aug 3, 2022

STAMP: SAMPLING TUMORS AND MEASURING PAIN IN NASAL CANCERS

Principle Investigator Michael W. Nolan Description Recruiting dogs with nasal carcinoma for a clinical trial studying the type of pain experienced by patients receiving radiation therapy. The goal of this project is to determine whether a certain class of proteins are increased in dogs that experience pain during (or shortly after) a course of radiotherapy…