October 10, 2019
A Breakthrough in Understanding Canine Itch
A new study from the NC State College of Veterinary Medicine is the first to pinpoint the intricate pathway mechanisms of itch in dogs, information vital to developing targeted treatments for common and chronic canine skin disorders. The research describes the expression of itch-signaling somatostatin and other major itch-associated neuropeptides and receptors in canine neurons.
September 27, 2019
Inflammation Amps Up Neurite Growth, Gene Expression Involved in Heat, Cold Sensitivity
Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal – but not physical– sensations in mice. The work sheds light on the role that inflammation-induced overexpression of calcium channel genes may play in pain hypersensitivity. Inflammation can often cause
June 13, 2018
Flipping the Switch on Itch: Researchers Identify Neuropeptide Involved in Transmitting Itch Signal to Brain in Eczema
Researchers from North Carolina State University have pinpointed a particular neuropeptide associated with transmitting itch signals in mice with atopic dermatitis. The work sheds further light on the pathways involved in transmitting itch sensations from the peripheral (skin) to the central (spinal cord) nervous system. “You can think of itch being transmitted from the skin
April 26, 2018
Scratching the Surface of Itch
Santosh Mishra is an assistant professor in the Department of Molecular Biomedical Sciences. He studies the neurological pathways involved in itch, in order to help us understand why and how we feel this sensation. He was recently involved in an international research collaboration aimed at identifying the process by which itch sensations are transmitted to the brain.
April 5, 2018
NC State CVM Awarded 3 Winn Feline Foundation Research Grants
The CVM took home three of the 14 grants awarded...
October 3, 2017
Neuroscientists Find ‘Gatekeeper’ in Itching Sensations Plays No Role in Pain Transmission
A study from North Carolina State University researchers shows that a neurotransmitter involved in relaying itching sensations from the skin to the spinal cord and into the brain plays no role in pain transmission. “For us, it’s very important to understand the neural circuits or pathways so that we can develop therapies specifically for pain
August 29, 2017
Fatty Acids and Itchy Skin – a Q&A with Santosh Mishra
Santosh Mishra, assistant professor of neuroscience at NC State Veterinary Medicine, was part of a team of NIH researchers who have discovered four previously unknown mediators for itch and pain in the skin. Identifying these mediators may be a first step toward providing relief for people who suffer from chronic skin conditions such as psoriasis.