{"id":27,"date":"2025-09-16T13:51:14","date_gmt":"2025-09-16T13:51:14","guid":{"rendered":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/?page_id=27"},"modified":"2026-04-21T14:29:59","modified_gmt":"2026-04-21T14:29:59","slug":"our-research","status":"publish","type":"page","link":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/our-research\/","title":{"rendered":"Ongoing Research"},"content":{"rendered":"\n\n\n\n<blockquote class=\"wp-block-ncst-blockquote\">\n    The Translational Research in Pain (TRiP) Lab focuses on understanding the mechanisms, assessment, and treatment of pain across species. Our work emphasizes translational approaches that support clinically relevant outcomes in both veterinary and human medicine.\n  <\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">Osteoarthritis &amp; Chronic Pain in Dogs: A Model for Human Pain<\/h3>\n\n\n\n<p>Naturally occurring osteoarthritis and osteosarcoma in pet dogs is very similar to the same conditions in humans. We study osteoarthritis and osteosarcoma in pet dogs<em> as models of the human conditions<\/em>, allowing us to both learn more about how to manage these painful conditions in dogs, and contribute to the development of non-opioid pain therapeutics in humans. We use a wide variety of validated subjective and objective outcome measures to assess putative analgesic drugs that may be developed for use. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Watch this video where experts in the veterinary and human pain fields talk about how pets can contribute to human pain research and benefit themselves.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Chronic Pain in Companion Animals\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/BY_9mk-PPRw?feature=oembed&#038;enablejsapi=1&#038;origin=https:\/\/cvm.ncsu.edu\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Gut Health &amp; Pain: An Emerging Focus<\/strong><\/h3>\n\n\n\n<p>The lab is expanding into emerging areas of pain research, including the role of the gut\u2013pain axis. Ongoing work examines how intestinal permeability (\u201cleaky gut\u201d) and related inflammatory processes may contribute to chronic pain.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Current studies in dogs with osteoarthritis are evaluating the effects of prebiotic supplementation on gut health, mobility, and pain outcomes. Using a randomized, double-blind clinical design, these studies combine caregiver-reported outcomes, activity monitoring, imaging, and non-invasive measures of gut permeability to assess how changes in the gut may influence pain and overall function.<\/li>\n<\/ul>\n\n\n\n<p>This approach supports the identification of novel therapeutic targets and strengthens the translation of gut-focused interventions into clinically relevant pain management strategies. For more information, click <a href=\"https:\/\/cvm.ncsu.edu\/gos-supplement-clinical-study\/\">here <\/a>to learn more. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/NJL0075-CE-1-1024x683.jpg\" alt=\"\" class=\"wp-image-471\" srcset=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/NJL0075-CE-1-1024x683.jpg 1024w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/NJL0075-CE-1-300x200.jpg 300w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/NJL0075-CE-1-768x513.jpg 768w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/NJL0075-CE-1-1536x1025.jpg 1536w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/NJL0075-CE-1-2048x1367.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Photo by Nathan Latil\/NC State Veterinary Medicine<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Advancing Pain Research Through Collaboration<\/strong><\/h3>\n\n\n<blockquote class=\"wp-block-ncst-blockquote\">\n    TRiP Lab research is highly collaborative and interdisciplinary. We work with partners across NC State and beyond, including ongoing collaborations with Dr. Mishra, Dr. Gruen, &amp; Dr. Nelson to incorporate behavioral, physiological, and clinical perspectives.\n  <\/blockquote>\n\n\n<div class=\"ncst-fancy-paragraph-fifty is-text wp-block-ncst-fancy-paragraph\">\n      \n<div class=\"text-only wp-block-ncst-fp-accompaniment\">\n    \n\n<h4 class=\"wp-block-heading\">Dr. Margaret E. Gruen<\/h4>\n\n\n\n<p><\/p>\n\n\n  <\/div>\n\n\n<div class=\"wp-block-ncst-fp-accompaniment\">\n    \n<div class=\"wp-block-ncst-fp-image\">\n  <figure class=\"fancy-paragraph__image-container fancy-paragraph__image-square\">\n          <img loading=\"lazy\" width=\"500\" height=\"500\" \n        decoding=\"async\"\n        class=\"fp-image wp-image-92\"\n        src=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Gruen-Margaret-1.jpg\"\n         alt=\"Margaret Gruen\" srcset=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Gruen-Margaret-1.jpg 500w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Gruen-Margaret-1-300x300.jpg 300w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Gruen-Margaret-1-150x150.jpg 150w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/>\n          <\/figure>\n<\/div>\n\n\n  <\/div>\n\n\n    <\/div>\n  \n\n\n<div class=\"ncst-fancy-paragraph-fifty is-text wp-block-ncst-fancy-paragraph\">\n      \n<div class=\"text-only wp-block-ncst-fp-accompaniment\">\n    \n\n<h4 class=\"wp-block-heading\">Dr. Santosh Mishra<\/h4>\n\n\n\n<p><\/p>\n\n\n  <\/div>\n\n\n<div class=\"wp-block-ncst-fp-accompaniment\">\n    \n<div class=\"wp-block-ncst-fp-image\">\n  <figure class=\"fancy-paragraph__image-container fancy-paragraph__image-square\">\n          <img loading=\"lazy\" width=\"250\" height=\"250\" \n        decoding=\"async\"\n        class=\"fp-image wp-image-93\"\n        src=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Mishra_Santosh_250.jpg\"\n         alt=\"Santosh Mishra I\" srcset=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Mishra_Santosh_250.jpg 250w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2025\/10\/Mishra_Santosh_250-150x150.jpg 150w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/>\n          <\/figure>\n<\/div>\n\n\n  <\/div>\n\n\n    <\/div>\n  \n\n\n<div class=\"ncst-fancy-paragraph-fifty is-text wp-block-ncst-fancy-paragraph\">\n      \n<div class=\"text-only wp-block-ncst-fp-accompaniment\">\n    \n\n<h4 class=\"wp-block-heading\">Dr. Amanda Nelson<\/h4>\n\n\n\n<p><\/p>\n\n\n  <\/div>\n\n\n<div class=\"wp-block-ncst-fp-accompaniment\">\n    \n<div class=\"wp-block-ncst-fp-image\">\n  <figure class=\"fancy-paragraph__image-container fancy-paragraph__image-square\">\n          <img loading=\"lazy\" width=\"584\" height=\"584\" \n        decoding=\"async\"\n        class=\"fp-image wp-image-475\"\n        src=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/Screenshot-2026-04-21-at-10.17.38-AM.png\"\n         alt=\"Dr. Amanda Nelson\" srcset=\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/Screenshot-2026-04-21-at-10.17.38-AM.png 584w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/Screenshot-2026-04-21-at-10.17.38-AM-300x300.png 300w, https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/Screenshot-2026-04-21-at-10.17.38-AM-150x150.png 150w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/>\n          <\/figure>\n<\/div>\n\n\n  <\/div>\n\n\n    <\/div>\n  \n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Osteoarthritis &amp; Chronic Pain in Dogs: A Model for Human Pain Naturally occurring osteoarthritis and osteosarcoma in pet dogs is very similar to the same conditions in humans. We study osteoarthritis and osteosarcoma in pet dogs as models of the human conditions, allowing us to both learn more about how to manage these painful conditions&hellip;<\/p>\n","protected":false},"author":50263,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/split-header","ncst_dynamicHeaderData":"{\"backgroundColor\":\"custombg_one\",\"imageID\":469,\"imageURL\":\"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-content\/uploads\/sites\/446\/2026\/04\/22017-Lascelles-DuBose-DP-2x3-042-scaled.jpg\",\"focalPoint\":{\"x\":0.49,\"y\":0.49},\"imageAlt\":\"Dr. Lascelles acception Duboise Award\"}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"class_list":["post-27","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/pages\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/users\/50263"}],"replies":[{"embeddable":true,"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/comments?post=27"}],"version-history":[{"count":10,"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/pages\/27\/revisions"}],"predecessor-version":[{"id":480,"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/pages\/27\/revisions\/480"}],"wp:attachment":[{"href":"https:\/\/cvm.ncsu.edu\/translational-research-in-pain\/wp-json\/wp\/v2\/media?parent=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}