arosari

Jul 16, 2025

Endocrine diseases assessment in horses

Principle Investigator Katarzyna Dembek Description Equine metabolic diseases are disorders that affect a horse’s metabolism, often leading to abnormal hormone function. The most common are Equine Metabolic Syndrome (EMS), linked to obesity and insulin resistance, and Pituitary Pars Intermedia Dysfunction (PPID), a condition affecting older horses due to pituitary gland dysfunction. These diseases increase the…

Jul 16, 2025

Short-term antimicrobial therapy for the treatment of mild to moderate bacterial pneumonia in adult horses

Principle Investigator Kate Hepworth-Warren Description Bacterial pneumonia is a common condition in horses that most often develops after long distance transportation, viral infections, or esophageal obstruction (choke). It can lead to prolonged and expensive therapy with potential complications including sepsis, laminitis, and death. In humans and small animals with bacterial pneumonia, guidelines suggest treating with…

Jul 16, 2025

Identifying innovative therapeutic targets and developing novel treatments for neutrophil-mediated conditions across veterinary and human patients

Principle Investigator Rosemary Bayless Description The Bayless Lab at NC State College of Veterinary Medicine is enrolling healthy mare/foal pairs to evaluate neutrophil function from time of birth through 6 months of age. The study will consist of physical examination and blood collection from the foal and mare when the foal is 24 hours, 72…

Jul 9, 2025

Efficacy of Potassium Citrate as a Treatment for Metabolic Acidosis in Cats with Chronic Kidney Disease

Principle Investigators Autumn N. Harris and Shelly Vaden Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. CKD is the most common typeof kidney disease and management has largely been focused on supportive and symptomatic therapy, with very few new…

Jul 3, 2025

TRAP-Paclitaxel for Equine Eyelid Squamous Cell Carcinoma

Principle Investigator Dr. Annie Oh Description This is a dose-escalation clinical trial to determine the effectiveness of a novel chemotherapeutic drug, TRAP-Paclitaxel, for the treatment of equine squamous cell carcinoma (SCC). The study will consist of an initial visit with biopsy, and 1-3 injections of TRAP-Paclitaxel at a minimum of 6 weeks apart. Horses will…

Mar 18, 2025

Cats with Hypertrophic Cardiomyopathy: The HALT HCM Study

Principle Investigator Sandra Tou Description This is a blinded, randomized, placebo-controlled clinical field study to provide substantial evidence of effectiveness of a disease modifying drug intervention in the management of ventricular hypertrophy in cats with subclinical Hypertrophic Cardiomyopathy (HCM). The study will consist of up to a 14-day screening period, followed by a 12-month once-weekly…

Mar 13, 2025

Now Recruiting Dogs with Acute Blindness Suspected to be Due to Optic Neuritis

Principle Investigator Dr Annie Oh Description Ophthalmology at NC State College of Veterinary Medicine is enrolling in a clinical study to measure VEPs (visual evoked potentials) and RNFL (retinal nerve fiber layer) thickness in dogs within 2 weeks of the onset of acute optic neuritis. The goal is to assess whether the presence or absence…

Feb 17, 2025

Effect of Iron Supplementation on the response to Varenzin-CA1 in Cats with CKD and Anemia

Principle Investigators Autumn N. Harris and Shelly Vaden Description Anemia is common in feline chronic kidney disease (CKD) and several options are available for treatment including the medication Varenzin CA-1 ® . Iron supplementation is an important part of the treatment of anemia in some patients with CKD and is given as standard of care…

Jan 6, 2025

Research Study for Senior Dogs: Targeting Frailty To Improve Healthspan and Well-Being

Description Over the past decade, there has been an increased interest in assessing frailty in our aging companion animals. The goal of this study is to monitor how frailty in senior dogs progresses over time, and how activity impacts their well-being. We hope to use what we learn to better care for our aging four…

Nov 21, 2024

A Blinded, Randomized, and Placebo-Controlled Clinical Trial of a Novel Veterinary Product for the Management of Chronic Kidney Disease in Cats

Principle Investigator Dr. Autumn Harris Description Evidence exists to suggest that aging of the kidney may contribute to the onset and progression of chronic kidney disease (CKD). Rapamycin is a drug that is a known modulator of the aging process and additionally may decrease the formation of fibrosis (scarring) in the kidney. A feline formulation…