clinical_trial

Apr 12, 2024

Now Recruiting Dogs with Babesia gibsoni

Principle Investigator Dr. Birkenheuer Description NC State College of Veterinary Medicine is enrolling dogs with Babesia gibsoni in a trial to evaluate if the use of a new drug combination (atovaquone/proguanil hydrochloride, azithromycin, and artemisinin) can improve treatment outcomes. A new treatment regimen using atovaquone/proguanil hydrochloride, azithromycin, and an artemisinin derivative has recently been shown to… 

Apr 3, 2024

Enrolling Cats with Oral Squamous Cell Carcinoma

Principle Investigator Dr. Nolan Description NC State College of Veterinary Medicine is recruiting cats with oral squamous cell carcinoma (SCC) for a new clinical trial. The purpose is to evaluate a new drug meant to enhance standard radiation therapy (RT). All cats will be treated with a standard course of radiation therapy (RT); some cats will… 

Jan 26, 2024

Now Enrolling Dogs with Early Stage Oral Malignant Melanoma

Principle Investigator Dr. Michael Nolan Description NC State University Veterinary Hospital is looking for dogs with stage I or II with oral melanoma for a clinical trial using a new therapeutic drug (GM-1111) and standard-of-care radiotherapy. The purpose of this clinical trial is to evaluate whether the novel therapy has: 1. Direct anti-cancer activity, 2. Capacity… 

Nov 9, 2023

Riluzole as a Neuroprotectant in Canine Degenerative Myelopathy

Principle Investigator Dr Natasha Olby Description This study will evaluate the effect of Riluzole, a drug already FDA-approved for the treatment of human ALS, on the progression of clinical signs in dogs with degenerative myelopathy (DM). This therapy has been previously tested for safety in dogs. The study will be randomized and blinded. This means… 

Oct 20, 2023

Now Enrolling Dogs with Invasive Bladder Cancer

Principle Investigator Dr. Paul Hess Description NC State Medical Oncology is enrolling patients for a clinical trial of an experimental immunotherapy for the treatment of bladder cancer. The primary purpose of this study is to investigate the safety and immune-stimulating properties of a novel therapy being developed at NCSU. Testing Requirements 8-day study (Monday – Monday)… 

Oct 16, 2023

New Research Study for Senior Dogs: Targeting Frailty To Improve Healthspan and Well-Being

Principle Investigators Dr. Margaret Gruen Dr. Natasha Olby Co-Investigator Dr. David Knazovicky Description The goal of this study is to monitor how frailty in senior dogs progresses over time, and how activity impacts their well-being. We hope to use what we learn to better treat senior dogs in the future. After the initial screening and… 

Oct 3, 2023

Seasonal Effect on Allergy Testing in Dogs with Atopic Dermatitis

Principle Investigator Dr. Petra Bizikova Description NC State Dermatology is looking for dogs that have Atopic Dermatitis due to airborne allergens to investigate the changes in the pattern and rate of allergen positivity during the different pollen peak seasons. The goal is to obtain a more comprehensive and accurate picture of the allergens that should be… 

Oct 3, 2023

Assessment of Hindlimb Function & Perfusion after Transcatheter PDA Occlusion

Principle Investigator Dr. Kursten Pierce Description Each patient undergoing transcatheter PDA occlusion will be assigned to either the femoral artery ligation group or the femoral artery repair group. Both methods have been described in literature and applied in practice as standard of care. Femoral artery repair will be performed by an experienced cardiology interventionalist to… 

Sep 28, 2023

Enrolling Dogs With Stifle or Hip Osteoarthritis on a Study Involving LIBRELA

Principle Investigator Masataka Enomoto, B. Duncan X. Lascelles Description Translational Research in Pain team is seeking dogs with osteoarthritis to take part in a study aiming to compare the efficacy of two FDA-approved medications. We will do this using computerized analysis of gait. Enrolled dogs will all receive one of the FDA approved drugs. (Half… 

Aug 3, 2023

Immunotherapy Clinical Trial for Patients with Oral Melanoma

Principal Investigator Dr. Michael Nolan Description NC State Veterinary Hospital is now recruiting dogs with oral malignant melanoma to evaluate the safety, tolerability, and efficacy of a novel immunotherapy. The immunotherapy is an antibody that aims to invigorate your dog’s immune system and help it eliminate cancer cells. Study Requirements Follow-up: After your screening appointment, you…