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clinical_trial

Feb 2, 2023

THE LEAKY GUT STUDY: EVALUATING THE RELATIONSHIP BETWEEN THE GUT AND JOINT HEALTH

Principle Investigator Duncan Lascelles Description NC State University College of Veterinary Medicine is seeking dogs with or without mobility problems that are 7 years of age or older and weigh at least 10 kg to take part in a study aiming to evaluate the relationship between intestinal permeability and multiple joint osteoarthritis. Testing Requirements This study… 

Jan 31, 2023

Screening urine samples from high-risk dog breeds for early bladder cancer

Principle Investigator Dr Shelly Vaden Description This study is screening urine samples from clinically healthy dogs at increased risk of bladder cancer, to determine if they test positive for a genetic marker of the disease (a specific mutation in the dog BRAF gene). The goal is to determine whether this BRAF Mutation Detection test can… 

Jan 31, 2023

Therapeutic trials for canine bladder cancer

Principle Investigator Dr Shelly Vaden Description This study will investigate whether the administration of a dietary supplement slows the progression of canine bladder cancer (also known as transitional cell carcinoma/urothelial carcinoma, or TCC/UC) in dogs treated with standard of care therapy Testing Requirements Participants will be asked to: – bring their dog for an initial… 

Jan 19, 2023

Now Enrolling Dogs with Bladder Cancer

Principle Investigator Dr. Michael Mastromauro Description NC State University College of Veterinary Medicine is enrolling in a clinical trial to investigate if a probiotic can improve cancer care and outcomes in dogs with bladder cancer. This is a placebo-controlled study, not all dogs will receive the probiotic, but all dogs will receivechemotherapy (vinblastine/piroxicam). Testing Requirements Dogs… 

Jan 18, 2023

Using the Chiari-like Malformation & Syringomyelia Evaluation (CHASE) Questionnaire* to Assess the Safety & Efficacy of a Novel Pain Management Product in Dogs

Principle Investigator Natasha Olby Description The goals of this study are to evaluate a newly developed questionnaire to assess pain and clinical signs associated with CM/SM in dogs and to evaluate how well a novel veterinary pain management product might treat the condition. Dogs with signs of CM/SM dogs will visit NC State Veterinary hospital for… 

Dec 19, 2022

Treatment of feline lymphocytic lymphoma/inflammatory bowel disease complex (FLL/IBD): A novel approach for managing the cat who’s impossible to pill

Principle Investigator Tracy Gieger Description Cats referred to NC State for assessment of chronic GI disease are eligible for initial screening. Cats treated with steroids or chemotherapy and cats that have been on hypoallergenic diet trials starting within 30 days of referral will be excluded. Your cat must have had general heath screening bloodwork (CBC and… 

Dec 19, 2022

Phase 1 Dose Escalation of Single-Agent Mechlorethamine HCl in Dogs with Lymphoma

Principle Investigator Dr. Joanne Intile Description We are recruiting dogs with lymphoma to determine the optimal dose of a chemotherapy drug called mustargen. Enrolled dogs will receive one free dose of mustargen and undergo follow up blood work for up to two weeks afterwards. Dogs can then receive other chemotherapy drugs, either at NCSU CVM… 

Sep 28, 2022

DOGS WITH NON-SEASONAL ATOPIC DERMATITIS TO INVESTIGATE THE EFFECTIVENESS OF TWO DIFFERENT DOSAGES OF A NOVEL IMMUNOTHERAPY DRUG

Principle Investigator Petra Bizikova Description Dogs with Non-Seasonal Atopic Dermatitis to Investigate the Effectiveness of Two Different Dosages of a Novel Immunotherapy Drug Testing Requirements – Patients will be required to come in for 10 visits over 24 weeks – Allergen-Specific IgE Serology (ASIS) testing at Heska – Patients will be required to stay for… 

Sep 26, 2022

THE EFFECT OF A NEW COMBINATION OF DIETARY SUPPLEMENTS ON ACTIVITY AND ATTENTION IN AGING DOGS

Description The Canine Neuro-aging Program at NC State College of Veterinary Medicine is recruiting dogs 10 years of age and older to participate in a study on a combination of anti-aging supplements aimed to improve cognitive function, mobility, and quality of life in older dogs. The basis for this study is rooted in our desire to… 

Sep 16, 2022

TRAUMA DOGS

NC State Veterinary Hospital is recruiting severely injured dogs or dogs with acute intra-abdominal hemorrhage from intra-abdominal masses, for enrollment in a clinical trial testing a clot-stabilizing drug called tranexamic acid (TXA). Background In humans, early administration of TXA following trauma significantly reduces mortality and risk of death from hemorrhage. Normally, blood clotting is a delicate…