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College of Veterinary Medicine
Comparative Behavioral Research
The Thinking Pets Program

Neuroaging and Olfaction

To read more about our research on neuroaging and olfaction in dogs, explore the articles and abstracts below

NEuroAging

Researchers guide study participant

A Reliable and Holistic Approach to Evaluating Hearing and Cognitive Auditory Processing in Adult and Aged Companion Dogs

Yang CC, Ruggeri M, Simon KE, Case B, Griffith EH, Gruen ME, Olby NJ. Sci Rep. 2026 Feb 10;16(1):8192. doi: 10.1038/s41598-026-39648-4.

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Aging is Modifiable: Current Perspectives on Healthy Aging in Companion Dogs and Cats

Moniot D. Allaway D, Bermingham E, Dowgray N, Gruen ME, Hoummady S, McKenzie B, Olby NJ, Schoeman T. J Am Vet Med Assoc. 2025 Oct 1;264(2):234-241. doi: 10.2460/javma.25.06.0412.

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Quantifying Placebo and Trial Participation Effects on Cognitive Outcome Measures in Aging Dogs

Simon KE, Russell K, Mondino A, Yang C, Case BC, Anderson Z, Whitley C, Griffith E, Gruen ME, Olby NJ. Geroscience. 2025 Dec;47(6):6909-6926. doi: 10.1007/s11357-025-01822-3. 

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clinician with a canine patient

Establishing a Clinically Applicable Frailty Phenotype Screening Tool for Aging Dogs

Russell K, Mondino A, Fefer G, Saker K, Gruen ME, Olby N. (2024) Front. Vet. Sci. 11:1335463.

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black and white photo of a black and white dog

Voxelwise Analysis of the Central Hearing Pathway in Senior Dogs Reveals Changes Associated with Fractional Lifespan

Yang C-C, Yap P-T, Wu Y, Zidan N, Fefer G, Nelson NC, Gruen ME, Olby NJ. (2024) Scientific Reports 14(18121).

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Total number of adverse events

A Randomized, Controlled Clinical Trial Demonstrates Improved Owner-Assessed Cognitive Function in Senior Dogs Receiving a Senolytic and NAD+ Precursor Combination

Simon KE, Russell K, Mondino A, Yang C, Case BC, Anderson Z, Whitley C, , Griffith E,
Gruen ME , Olby NJ . Sci Rep 14, 12399 (2024).

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diagram showing study results

Cross-sectional and Longitudinal Analysis of Health-Related Quality of Life (HRQoL) in Senior and Geriatric Dogs

Mondino A, Yang C, Simon KE, Fefer G, Robertson J, Gruen ME, Olby NJ. (2024)  PLOS ONE 19(9): e0301181

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happy golden retriever

Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs

Templeton GB, Fefer G, Case BC, Roach R, Azcarate MA, Gruen ME, Callahan BJ, Olby N. (2023) Animals 13(24), 3846

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canine participant being guided by clinician in a study exercise

Winning the Race with Aging: Age-Related Changes in Gait Speed and Its Association with Cognitive Performance in Dogs

Mondino A, Khan M, Case B, Fefer G, Panek WK, Gruen ME, Olby N. (2023) Front. Vet. Sci. 10:1150590.

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Beagle being examined by veterinarian

Age-Associated Changes in Electroretinography Measures in Companion Dogs

Salzman MM, Merten N, Panek WK, Fefer G, Mondino A, Westermeyer HD, Gruen ME, Olby NJ, Mowat FM. (2023) Documenta Ophthalmologica, 147(1): 15-28.

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Dr. Olby with clinical study participant

Sleep and Cognition in Aging Dogs. A Polysomnographic Study

Mondino A, Catanzariti M, Mateos DM, Khan M, Ludwig C, Kis A, Gruen ME, Olby NJ. (2023) Front. Vet. Sci. 10:1151266.

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A Novel Task of Canine Olfaction for Use in Adult and Senior Pet Dogs

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. Sci Rep 13, 2224 (2023).

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Diagram displaying graph data of activity patterns

Activity Patterns are Associated with Fractional Lifespan, Memory, and Gait Speed in Aged Dogs

Mondino A, Khan M, Case B, Giovagnoli S, Thomson A, Lascelles BDX, Gruen ME, Olby N.  2023 Feb 14;13:2588. Nature Scientific Reports

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Development and Validation of a Sleep Questionnaire, SNoRE 3.0, to Evaluate Sleep in Companion Dogs

Mondino, A., Ludwig, C., Menchaca, C. et al. Sci Rep 13, 13340 (2023).

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Activity Patterns are Associated with Fractional Lifespan, Memory, and Gait Speed in Aged Dogs

Mondino A, Khan M, Case B, Giovagnoli S, Thomson A, Lascelles BDX, Gruen ME, Olby N. (2023). Nature Scientific Reports, 13

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Relationship Between Engagement with the Impossible Task, Cognitive Testing, and Cognitive Questionnaires in a Population of Aging Dogs

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. (2023). Frontiers in Veterinary Science

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Use of Cognitive Testing, Questionnaires and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer G, Panek WK, Khan MZ, Singer M, Westermeyer H, Mowat FM, Murdoch DM, Case B, Olby NJ*, Gruen ME*. (2022). Journal of Alzheimers Disease, Jan. 2022:1367 – 1378.

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Relationship Between Hearing, Cognitive Function, and Quality of Life in Aging Companion Dogs

Fefer G, Khan MZ, Panek WK, Case B, Gruen ME*, Olby NJ*. (2022). Journal of Veterinary Internal Medicine, 36 (5), 1708-1718.

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Static Posturography as a Novel Measure of the Effects of Aging on Postural Control in Dogs

Mondino A., Wagner G., Russell K., Lobaton E., Griffith E, Gruen, M., . . . Olby, N. J. (2022). PLoS ONE, 17(7), 1-20.

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Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., . . . Gruen, M. E. (2022). Journal of Alzheimer’s Disease, 87(3), 1367-1378.

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Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience

McKenzie, B. A., Chen, F. L., Gruen, M. E., & Olby, N. J. (2022). Frontiers in Veterinary Science, 9, 1-13.

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Age-related Visual Decline in Companion Dogs: A Cross-sectional ERG Study in a Translational Model Species

Mowat, F. M., Panek, W. K., Fefer, G., Banghart, M., Wagner, G., Westermeyer, H. D., . . . Olby, N. (2021). Investigative Ophthalmology & Visual Science, 62(8), 500.

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Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs

Panek, W. K., Murdoch, D. M., Gruen, M. E., Mowat, F. M., Marek, R. D., & Olby, N. J. (2021). Molecular Neurobiology, 58(2), 483-489.

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Sustained Gaze is a Reliable In-home Test of Attention for Aging Pet Dogs

Hoel, J. A., Templeton, G. B., Fefer, G., Case, B. C., Shah, A., Gruen, M. E., & Olby, N. J. (2021). Frontiers in Veterinary Science, 8, 1-9.

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Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs

Panek, W. K., Gruen, M. E., Murdoch, D. M., Marek, R. D., Statchel, A. F., Mowat, F. M., . . . Olby, N. J. (2020). Molecular Neurobiology, 57(7), 3143-3149.

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Olfaction

A Novel Test of Canine Olfaction for Use in Adult and Senior Pet Dogs

Khan MZ, Mondino A, Russell K, Case B, Fefer G, Woods H, Olby N, Gruen ME. (2023). Nature Scientific Reports

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Olfactory Discrimination and Generalization of Ammonium Nitrate and Structurally Related Odorants in Labrador Retrievers

Lazarowski, L., Foster, M. L., Gruen, M. E., Sherman, B. L., Fish, R. E, Milgram, N. W., & Dorman, D. C. (2015). Animal Cognition, 18(6), 1255-1265.

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