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Now Recruiting Dogs with Babesia gibsoni

clinical_trial

Aug 28, 2024

Ammonia Excretion, A Novel Biomarker and Therapeutic Target for Feline CKD

Principle Investigator Dr. Harris Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. Serum creatinine is currently used as a marker of kidney function, but it cannot detect early changes in kidney function. Detecting CKD early has significant importance because…

Aug 28, 2024

Novel Biomarker and Therapeutic Target for CKD in Dogs

Principle Investigator Dr. Harris Description Chronic Kidney Disease (CKD) is defined as the presence of functional abnormalities in one or both kidneys over a prolonged period of time. Serum creatinine is currently used as a marker of kidney function, but it cannot detect early changes in kidney function. Detecting CKD early has significant importance because…

Jul 11, 2024

Dogs with Non-Seasonal Atopic Dermatitis

Principle Investigator Ina Herrmann Description This study is looking for dogs that have non-seasonal atopic dermatitis for a trial to investigate a novel injectable medication similar to Xolair®/Omalizumab with the potential to control the disease for weeks to months. The goal of this study is to reduce the need for daily medications and improving the…

Jul 8, 2024

Feline Idiopathic Cystitis (FIC)

Principle Investigator Allison Kendall Description This study is looking for felines that have FIC (feline idiopathic cystitis). The goal is to test low-dose radiation therapy of the urinary tract, which is intended to reduce pain, inflammation and clinical signs of FIC (feline idiopathic cystitis). Testing Requirements Total participation is 1 year but the patient would…

Jul 8, 2024

Pulse Therapy with Clorazepate or Levetiracetam for Cluster Seizures

Principle Investigator Dr. Karen Munana Description We are seeking dogs with idiopathic epilepsy that experience cluster seizures for a new study led by Drs. Karen Muñana and Alejandra Mondino, evaluating pulse therapy for the in-home treatment of cluster seizures. This study is funded by the AKC-Canine Health Foundation. Dogs will be recruited based on the…

Jun 19, 2024

The Pathogenesis of Immune-Mediated Hemolytic Anemia (IMHA)

Principle Investigator Erika Gruber Description NC State University College of Veterinary Medicine is looking for IMHA patients for a blood sample study. The purpose of this project is to investigate whether a key pathway that inhibits phagocytosis (cell ingestion) contributes to IMHA pathogenesis. CD47 (“don’t eat me” signal) is a marker of “self” that negatively…

Jun 3, 2024

Feline Congestive Heart Failure and Coagulation

Principle Investigator Teresa DeFrancesco Description Cats with congestive heart failure (abnormal fluid accumulation) are at high risk for developing blood clots but the risk appears to differ with the manifestation of heart failure. There are two different manifestations of congestive heart failure in cats: 1) primarily pulmonary edema, and 2) primarily pleural effusion. Pulmonary edema…

May 29, 2024

Oral rapamycin for Severe Subvalvular Aortic Stenosis (SAS) in Dogs

Principle Investigator Kursten Pierce Description The purpose of this study is to evaluate whether three times weekly dosing with oral rapamycin can reverse the heart muscle changes associated with subvalvular aortic stenosis (SAS) in dogs. Dogs will undergo an initial screening for eligibility. If your dog enrolls, they will be randomized to receive either low…

May 14, 2024

Clinical Trial for Equine Eyelid Squamous cell carcinoma

Principle Investigator Dr. Annie Oh Description Squamous cell carcinoma (SCC) is the most common cancer impacting the equine eye and is the second most common equine cancer overall. If left untreated, it can grow to infiltrate multiple ocular structures, in addition to the cornea and bony orbit, due to its locally aggressive nature. The purpose…

Apr 12, 2024

Now Recruiting Dogs with Babesia gibsoni

Principle Investigator Dr. Birkenheuer Description NC State College of Veterinary Medicine is enrolling dogs with Babesia gibsoni in a trial to evaluate if the use of a new drug combination (atovaquone/proguanil hydrochloride, azithromycin, and artemisinin) can improve treatment outcomes. A new treatment regimen using atovaquone/proguanil hydrochloride, azithromycin, and an artemisinin derivative has recently been shown…