PIVOT-C: Pilot Intratumoral Vaccine Therapy For Oral Tumors in Cats

July 15, 2025 2-min. read

Principle Investigator

Description

This study investigates the safety and potential benefits of injecting a commonly used feline vaccine (FVRCP) directly into tumors. The goal is to gain a deeper understanding of the feasibility of intratumoral injection for treatment and how this approach may affect the tumor environment and stimulate an anti-tumor immune response.

Please note that while enrolled in the study, cats are not eligible to receive surgery or radiation therapy. These treatments may still be considered after the study is completed or if your cat exits the study early.

Testing Requirements

Cats diagnosed with an oral mass may be eligible to participate in this clinical research study, which lasts a total of 28 days. During the study period, your cat will visit the NC State Veterinary Hospital once a week, on Days 0, 7, 14, 21, and 28. At each visit, your cat will receive a physical exam and tumor assessment to monitor treatment response and overall health.

As part of the study, your cat will receive an intratumoral injection of the FVRCP vaccine at each weekly visit. To safely administer the vaccine, your cat will be sedated for the procedure. In addition, two small tumor biopsies may be collected under sedation or general anesthesia: one before treatment begins (Day 0) and one after the study (Day 28).

Enrollment Start

09/01/2025

Enrollment Finish

12/31/2027

Eligibility

Cats diagnosed with an oral mass
Adequate liver/kidney function
Adequate red and white blood cell counts and platelet counts
Cats must be eating/drinking on their own
Expected lifespan of at least 6 weeks