clinical trials

Aug 3, 2022

LONGITUDINAL STUDY OF NEURO-AGING IN DOGS

Principal Investigator Natasha Olby Description Canine Cognitive Dysfunction is an age-related neurobehavioral condition that shares similar features to Alzheimer’s disease observed in humans. The progression of this devastating disease ultimately leads to the decline in cognitive function, severely affecting comfort of life for dogs and their owners. The purpose of this study is to track…

Aug 3, 2022

EARLY INTERVENTION FOR DOBERMAN PINSCHERS AT RISK OF DEVELOPING DILATED CARDIOMYOPATHY

Principal Investigator Kathryn Meurs Description We recently identified a genetic mutation in the Titin gene as a common cause of fatal dilated cardiomyopathy in the Doberman pinscher. Dogs that develop the disease frequently die of the disease either from refractory congestive heart failure or sudden cardiac death. Previous studies have demonstrated that medical intervention of…

Aug 3, 2022

DOGS DIAGNOSED WITH PRIMARY SPONTANEOUS PNEUMOTHORAX

Principal Investigator Valery Scharf Description NC State University College of Veterinary Medicine is evaluating the feasibility of thoracoscopy (minimally invasive surgery) for the identification and localization of pulmonary bullae associated with spontaneous pneumothorax. The current approach to this disease is open surgical exploration via a median sternotomy; by demonstrating the ability of thoracoscopy to identify…

Aug 3, 2022

CLINICAL TRIAL FOR DOGS WITH PRIMARY ANGLE CLOSURE GLAUCOMA

Principal Investigator Hans Westermeyer Testing Requirements Your dog will receive an exam from the NC State Ophthalmology Service 1 month after study enrollment and once every 3 months thereafter. Each visit will include: sedation, a complete ophthalmic exam, photography and ultrasound of the eye’s drainage apparatus, retinal thickness measurement, and quantitative pupillary light reflex evaluation.…

Aug 3, 2022

MEDICAL RESOLUTION OF GALLBLADDER MUCOCELE FORMATION IN DOGS

Principal Investigator Jody Gookin Testing Requirements – Exclusive feeding of Royal Canin Gastrointestinal Low Fat dry or canned food with a 10% snack allowance for up to 1 year (paid for by study). Your dog’s feeding plan will be prescribed and monitored by a veterinary nutritionist. – Oral administration of up to 15 capsules of…

Aug 3, 2022

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principal Investigator Dr. Mike Sano Description This study is looking for dogs with 1-2 discrete mammary tumors measuring between 1-3cm to participate in a clinical trial that is investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. Owners will need to bring their dog…

Aug 3, 2022

Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer 

Principal Investigator Dr Shelly Vaden Description This study will investigate: 1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs. 2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary…

Aug 3, 2022

Osteoarthritis Oral Microbiome Analysis in Dogs

Principal Investigator Jody Gookin Description A one-time saliva sample from your dog to analyze their oral microbiome (the microbial composition of their mouths). The analysis will allow us to identify patterns associated with the presence or absence of certain diseases. Testing Requirements A one-time visit to NCSU for a physical exam and  saliva sample.  There…

Aug 2, 2022

FUNCTIONAL CONNECTIVITY MRI IN DOGS WITH IDIOPATHIC EPILEPSY

Principal Investigator Karen Munana Description We are recruiting dogs with idiopathic epilepsy that have experienced at least 2 seizures and are not on antiseizure medications. Dogs that qualify will receive a brain MRI and spinal tap free of charge. For additional details, see: Epilepsy functional MRI Testing Requirements None Enrollment Start 06/01/2022 Enrollment Finish 12/31/2024…