Skip to main content

EARLY INTERVENTION FOR DOBERMAN PINSCHERS AT RISK OF DEVELOPING DILATED CARDIOMYOPATHY

Principle Investigator

Kathryn Meurs

Description

We recently identified a genetic mutation in the Titin gene as a common cause of fatal dilated cardiomyopathy in the Doberman pinscher. Dogs that develop the disease frequently die of the disease either from refractory congestive heart failure or sudden cardiac death. Previous studies have demonstrated that medical intervention of dogs with early cardiomyopathy prolongs the development of congestive heart failure. In this study we are enrolling Doberman pinschers with the mutation who are between 3-4 years of age who have not yet developed heart disease. Dogs will be started on therapy and will be followed every 6 -12 months until they develop the disease or become 8 years of age. We propose that frequent surveillance of mutation positive dogs and early intervention with medical therapy can prolong the development of heart failure even longer.

Testing Requirements

Echocardiogram
24 hour ECG (Holter)
BNP

Enrollment Start

07/15/2019

Enrollment Finish

07/01/2023

Eligibility

Between 3-4 years of age)
Positive for DCM2 (titin) Mutation)
No evidence of heart disease on echocardiogram

Contact

Julia Condit: cvm-cardiacgenetics@ncsu.edu
Kathryn Meurs: Kate_meurs@ncsu.edu