Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer
Dr Shelly Vaden
This study will investigate:
1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs.
2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary BRAF mutation, but which have no existing clinical signs of urothelial carcinoma/bladder cancer.
3. whether the same dietary supplement slows progression of the disease in dogs recently diagnosed with urothelial carcinoma/bladder cancer , when provided in combination with standard of care treatment.
Participants will be asked to:
- bring your dog for an initial clinical evaluation at NC State College of Veterinary Medicine
- provide your dog with the supplied dietary supplement (or placebo) – a once-daily tablet
- submit a urine sample from your dog to the study each month
- complete a short online questionnaire each month
Study benefits (provided at no cost to enrolled participants) include:
- monthly screening of your dog’s urine with our BRAF Mutation Detection test (a DNA-based marker of canine urothelial carcinoma/bladder cancer)
- clinical evaluation of your dog for the presence of urothelial carcinoma/bladder cancer
- standard of care treatment (for dogs diagnosed with urothelial carcinoma/bladder cancer, which may include chemotherapy)
- a daily dietary supplement or placebo
- periodic clinical re-evaluation of your dog
To be eligible for enrollment a dog must either:
a) have been diagnosed with urothelial carcinoma/bladder cancer within the past six weeks, and have not begun chemotherapy
b) be aged six years or older, with no obvious signs of urothelial carcinoma/bladder cancer (such as straining to urinate, blood in the urine) AND be from one of the following breeds: American Eskimo Dog, Beagle, Russell Terrier, Parson Russell Terrier, Scottish Terrier, Shetland Sheepdog, West Highland White Terrier