Enrolling Cats with Oral Squamous Cell Carcinoma
Principle Investigator
Description
**Currently only enrolling for Phase I only**
NC State College of Veterinary Medicine is recruiting cats with oral squamous cell carcinoma (SCC) for a new clinical trial. The purpose is to evaluate a new drug meant to enhance standard radiation therapy (RT). All cats will be treated with a standard course of radiation therapy (RT); some cats will also receive the novel radiation-enhancing drug.
In Phase I, a group of cats will receive RT alone. In essence, Phase I is the “control” arm of this study, giving us a set of data so that we can carefully study what happens with RT alone.
In Phase II, a group of cats will receive RT plus Camonsertib. Camonsertib is the radiation-enhancing drug, and it will be given by our team while your cat is in the hospital.
Note: The RT is given as three outpatient treatments over the span of 8 days. This treatment is intended to reduce pain and shrink the tumor. Although unlikely, the treatment may cause skin irritation, which looks and feels like a sunburn – we can give medicine to help with that if needed. Similar irritation could affect the lining of the mouth and throat.
Testing Requirements
Prior to entering the study your cat must already have a diagnosis of oral SCC.
Immediately upon entry into the study your cat will have some baseline “staging” tests to determine the extent of cancer throughout their body.
During the study, biopsy samples of the tumor will be collected before and after RT, and cats will be monitored via a series of recheck visits to determine how well they have responded to RT.
Occasional blood tests will also be performed.
Enrollment Start
04/03/2024
Enrollment Finish
04/01/2025
Eligibility
- Have a biopsy-confirmed diagnosis of oral SCC (any location in the mouth)
- Be otherwise healthy (as assessed via physical exam, bloodwork, and imaging)
- Have had no prior treatment with either chemotherapy or RT
Study Benefits
All required testing and treatment will be provided by our team of veterinary oncology experts, at no cost to you. Total estimated value: $8,500.
Participation
You will be required to bring your cat to NC State Veterinary Hospital for:
- 1 screening visit
- 3 radiation treatment sessions
- A series of recheck visits (1 and 2 weeks after RT, then once monthly)
Flyer
Contact
To inquire about participation, contact Dr. Effie Palyvou at epalyvo@ncsu.edu
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