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Enrolling Cats with Oral Squamous Cell Carcinoma

Principle Investigator

Dr. Nolan


NC State College of Veterinary Medicine is recruiting cats with oral squamous cell carcinoma (SCC) for a new clinical trial. The purpose is to evaluate a new drug meant to enhance standard radiation therapy (RT). All cats will be treated with a standard course of radiation therapy (RT); some cats will also receive the novel radiation-enhancing drug.

In Phase I, a group of cats will receive RT alone; BAY 1895344 will not be given. Biopsy samples of the tumor will be collected before and after RT, and cats will be monitored via a series of recheck visits to determine how well they have responded to RT. In essence, Phase I is the “control” arm of this study, giving us a set of data so that we can carefully study what happens with RT alone.

Testing Requirements

Radiation therapy: Given as three treatments. This treatment is intended to reduce pain and shrink the tumor. Although unlikely, the treatment may cause skin irritation, which looks and feels like a sunburn – we can give medicine to help with that if needed. Similar irritation could affect the lining of the mouth and throat.

**Currently only enrolling for Phase I**

Enrollment Start


Enrollment Finish



Have a biopsy-confirmed diagnosis of oral SCC (any location in the mouth)
Be otherwise healthy (as assessed via physical exam, bloodwork, and imaging)
Have had no prior treatment with either chemotherapy or RT




To inquire about participation, contact the Clinical Studies Core