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Oral rapamycin for Severe Subvalvular Aortic Stenosis (SAS) in Dogs

Principle Investigator

Kursten Pierce

Description

The purpose of this study is to evaluate whether three times weekly dosing with oral rapamycin can reverse the heart muscle changes associated with subvalvular aortic stenosis (SAS) in dogs.

Dogs will undergo an initial screening for eligibility. If your dog enrolls, they will be randomized to receive either low dose rapamycin, high dose rapamycin, or placebo in a double blinded fashion and return for 3 and 6 month recheck visits.

Testing Requirements

The initial screening for eligibility will include:

• A physical examination by the cardiologist
• Blood tests and urinalysis
• A blood pressure measurement
• An electrocardiogram (ECG) to evaluate heart rhythm
• Chest x-rays
• An echocardiogram (cardiac ultrasound) to evaluate the heart muscle measurements and confirm a diagnosis of severe SAS
• A 24-hour ECG known as a Holter monitor in the home environment.
• Dogs may require light sedation to help them relax during the testing

The 3 month recheck visit will include:

• A physical examination by the cardiologist
• Blood tests and urinalysis
• An electrocardiogram (ECG) to evaluate heart rhythm
• An echocardiogram (cardiac ultrasound) to evaluate the heart muscle measurements

The 6 month recheck visit will include:

• A physical examination by the cardiologist
• Blood tests and urinalysis
• A blood pressure measurement
• An electrocardiogram (ECG) to evaluate heart rhythm
• Chest x-rays
• An echocardiogram (cardiac ultrasound) to evaluate the heart muscle measurements
• A 24-hour ECG known as a Holter monitor in the home environment.
• Dogs may require light sedation to help them relax during the testing

Enrollment Start

06/01/2024

Enrollment Finish

02/01/2025

Eligibility

Dogs with severe SAS in the absence of other congenital or acquired heart disease
Dogs free of other systemic illness

Flyer

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Contact

Please contact the Clinical Studies Core @ CVMclinicalstudies@ncsu.edu