EARLY INTERVENTION FOR DOBERMAN PINSCHERS AT RISK OF DEVELOPING DILATED CARDIOMYOPATHY
Principal Investigator
Description
We recently identified a genetic mutation in the Titin gene as a common cause of fatal dilated cardiomyopathy in the Doberman pinscher. Dogs that develop the disease frequently die of the disease either from refractory congestive heart failure or sudden cardiac death. Previous studies have demonstrated that medical intervention of dogs with early cardiomyopathy prolongs the development of congestive heart failure. In this study we are enrolling Doberman pinschers with the mutation who are between 3-4 years of age who have not yet developed heart disease. Dogs will be started on therapy and will be followed every 6 -12 months until they develop the disease or become 8 years of age. We propose that frequent surveillance of mutation positive dogs and early intervention with medical therapy can prolong the development of heart failure even longer.
Testing Requirements
Echocardiogram
24 hour ECG (Holter)
BNP
Enrollment Start
07/15/2019
Enrollment Finish
12/31/2024
Eligibility
Between 3-4 years of age)
Positive for DCM2 (titin) Mutation)
No evidence of heart disease on echocardiogram
Contact
cvm-cardiacgenetics@ncsu.edu
Kathryn Meurs: Kate_meurs@ncsu.edu
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