Dogs

Jan 18, 2023

Using the Chiari-like Malformation & Syringomyelia Evaluation (CHASE) Questionnaire* to Assess the Safety & Efficacy of a Novel Pain Management Product in Dogs

Principal Investigator Natasha Olby Description The goals of this study are to evaluate a newly developed questionnaire to assess pain and clinical signs associated with CM/SM in dogs and to evaluate how well a novel veterinary pain management product might treat the condition. Dogs with signs of CM/SM dogs will visit NC State Veterinary hospital for… 

Dec 19, 2022

Phase 1 Dose Escalation of Single-Agent Mechlorethamine HCl in Dogs with Lymphoma

Principal Investigator Dr. Joanne Intile Description We are recruiting dogs with lymphoma to determine the optimal dose of a chemotherapy drug called mustargen. Enrolled dogs will receive one free dose of mustargen and undergo follow up blood work for up to two weeks afterwards. Dogs can then receive other chemotherapy drugs, either at NCSU CVM… 

Sep 26, 2022

THE EFFECT OF A NEW COMBINATION OF DIETARY SUPPLEMENTS ON ACTIVITY AND ATTENTION IN AGING DOGS

Description The Canine Neuro-aging Program at NC State College of Veterinary Medicine is recruiting dogs 10 years of age and older to participate in a study on a combination of anti-aging supplements aimed to improve cognitive function, mobility, and quality of life in older dogs. The basis for this study is rooted in our desire to… 

Aug 3, 2022

LONGITUDINAL STUDY OF NEURO-AGING IN DOGS

Principal Investigator Natasha Olby Description Canine Cognitive Dysfunction is an age-related neurobehavioral condition that shares similar features to Alzheimer’s disease observed in humans. The progression of this devastating disease ultimately leads to the decline in cognitive function, severely affecting comfort of life for dogs and their owners. The purpose of this study is to track… 

Aug 3, 2022

EARLY INTERVENTION FOR DOBERMAN PINSCHERS AT RISK OF DEVELOPING DILATED CARDIOMYOPATHY

Principal Investigator Kathryn Meurs Description We recently identified a genetic mutation in the Titin gene as a common cause of fatal dilated cardiomyopathy in the Doberman pinscher. Dogs that develop the disease frequently die of the disease either from refractory congestive heart failure or sudden cardiac death. Previous studies have demonstrated that medical intervention of… 

Aug 3, 2022

DOGS DIAGNOSED WITH PRIMARY SPONTANEOUS PNEUMOTHORAX

Principal Investigator Valery Scharf Description NC State University College of Veterinary Medicine is evaluating the feasibility of thoracoscopy (minimally invasive surgery) for the identification and localization of pulmonary bullae associated with spontaneous pneumothorax. The current approach to this disease is open surgical exploration via a median sternotomy; by demonstrating the ability of thoracoscopy to identify pulmonary… 

Aug 3, 2022

CLINICAL TRIAL FOR DOGS WITH PRIMARY ANGLE CLOSURE GLAUCOMA

Principal Investigator Hans Westermeyer Testing Requirements Your dog will receive an exam from the NC State Ophthalmology Service 1 month after study enrollment and once every 3 months thereafter. Each visit will include: sedation, a complete ophthalmic exam, photography and ultrasound of the eye’s drainage apparatus, retinal thickness measurement, and quantitative pupillary light reflex evaluation. A… 

Aug 3, 2022

MEDICAL RESOLUTION OF GALLBLADDER MUCOCELE FORMATION IN DOGS

Principal Investigator Jody Gookin Testing Requirements – Exclusive feeding of Royal Canin Gastrointestinal Low Fat dry or canned food with a 10% snack allowance for up to 1 year (paid for by study). Your dog’s feeding plan will be prescribed and monitored by a veterinary nutritionist. – Oral administration of up to 15 capsules of… 

Aug 3, 2022

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principal Investigator Kyle Mathews Description This study is looking for dogs with 1-2 discrete mammary tumors measuring between 1-3cm to participate in a clinical trial that is investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. Owners will need to bring their dog to… 

Aug 3, 2022

Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer 

Principal Investigator Dr Shelly Vaden Description This study will investigate: 1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs. 2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary…