Oncology

Apr 3, 2024

Enrolling Cats with Oral Squamous Cell Carcinoma

Principle Investigator Dr. Nolan Description **Currently only enrolling for Phase I only** NC State College of Veterinary Medicine is recruiting cats with oral squamous cell carcinoma (SCC) for a new clinical trial. The purpose is to evaluate a new drug meant to enhance standard radiation therapy (RT). All cats will be treated with a standard…

Jan 26, 2024

(Not Currently Enrolling) Dogs with Early Stage Oral Malignant Melanoma

Principle Investigator Dr. Michael Nolan Description NC State University Veterinary Hospital is looking for dogs with stage I or II with oral melanoma for a clinical trial using a new therapeutic drug (GM-1111) and standard-of-care radiotherapy. The purpose of this clinical trial is to evaluate whether the novel therapy has:1. Direct anti-cancer activity,2. Capacity to…

Oct 20, 2023

Now Enrolling Dogs with Invasive Bladder Cancer

Principle Investigator Dr. Paul Hess Description NC State Medical Oncology is enrolling patients for a clinical trial of an experimental immunotherapy for the treatment of bladder cancer. The primary purpose of this study is to investigate the safety and immune-stimulating properties of a novel therapy being developed at NCSU. Testing Requirements 8-day study (Monday –…

Aug 3, 2023

(CLOSED) Immunotherapy Clinical Trial for Patients with Oral Melanoma

Principal Investigator Dr. Michael Nolan Description NC State Veterinary Hospital is now recruiting dogs with oral malignant melanoma to evaluate the safety, tolerability, and efficacy of a novel immunotherapy. The immunotherapy is an antibody that aims to invigorate your dog’s immune system and help it eliminate cancer cells. Study Requirements Follow-up: After your screening appointment,…

Jul 18, 2023

Now Enrolling Canine Patients with Liver Tumors

Principle Investigator Dr. Mike Sano Description Does your dog have a liver tumor? We are now enrolling canine patients that have a liver tumor into a clinical trial that is using a new therapy called INSPIRE, which uses electrical pulses to safely destroy the cells within a tumor. This study has two treatment groups. One…

Jan 31, 2023

Screening urine samples from high-risk dog breeds for early bladder cancer

Principal Investigator Dr Shelly Vaden Description This study is screening urine samples from clinically healthy dogs at increased risk of bladder cancer, to determine if they test positive for a genetic marker of the disease (a specific mutation in the dog BRAF gene). The goal is to determine whether this BRAF Mutation Detection test can…

Jan 31, 2023

Therapeutic trials for canine bladder cancer (NOT CURRENTLY RECRUITING)

Principal Investigator Dr Shelly Vaden Description This study will investigate whether the administration of a dietary supplement slows the progression of canine bladder cancer (also known as transitional cell carcinoma/urothelial carcinoma, or TCC/UC) in dogs treated with standard of care therapy Testing Requirements Participants will be asked to: – bring their dog for an initial…

Jan 19, 2023

Now Enrolling Dogs with Bladder Cancer

Principal Investigator Dr. Michael Mastromauro Description NC State University College of Veterinary Medicine is enrolling in a clinical trial to investigate if a probiotic can improve cancer care and outcomes in dogs with bladder cancer. This is a placebo-controlled study, not all dogs will receive the probiotic, but all dogs will receivechemotherapy (vinblastine/piroxicam). Testing Requirements…

Dec 19, 2022

Phase 1 Dose Escalation of Single-Agent Mechlorethamine HCl in Dogs with Lymphoma

Principal Investigator Dr. Joanne Intile Description We are recruiting dogs with lymphoma to determine the optimal dose of a chemotherapy drug called mustargen. Enrolled dogs will receive one free dose of mustargen and undergo follow up blood work for up to two weeks afterwards. Dogs can then receive other chemotherapy drugs, either at NCSU CVM…

Aug 3, 2022

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principal Investigator Dr. Mike Sano Description This study is looking for dogs with 1-2 discrete mammary tumors measuring between 1-3cm to participate in a clinical trial that is investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. Owners will need to bring their dog…