Oncology

Jul 3, 2025

TRAP-Paclitaxel for Equine Eyelid Squamous Cell Carcinoma

Principle Investigator Dr. Annie Oh Description This is a dose-escalation clinical trial to determine the effectiveness of a novel chemotherapeutic drug, TRAP-Paclitaxel, for the treatment of equine squamous cell carcinoma (SCC). The study will consist of an initial visit with biopsy, and 1-3 injections of TRAP-Paclitaxel at a minimum of 6 weeks apart. Horses will…

Mar 6, 2025

Now Recruiting Dogs with Bone Cancer

Principle Investigator Dr. Nolan Description NC State is recruiting dogs with bone cancer (osteosarcoma) for a clinical trial that compares 2 radiotherapy approaches. Each enrolled dog will get a singledose of radiotherapy, followed within 3 weeks by standard surgery (limb amputation). Testing Requirements Large or giant breed dogs may be eligible if they have:– X-rays…

Apr 3, 2024

Enrolling Cats with Oral Squamous Cell Carcinoma

Principle Investigator Dr. Nolan Description **Currently enrolling for Phase 2** NC State College of Veterinary Medicine is recruiting cats with oral squamous cell carcinoma (SCC) for a new clinical trial. The purpose is to evaluate a new drug meant to enhance standard radiation therapy (RT). All cats will be treated with a standard course of…

Oct 20, 2023

Now Enrolling Dogs with Invasive Bladder Cancer

Principle Investigator Dr. Paul Hess Description NC State Medical Oncology is enrolling patients for a clinical trial of an experimental immunotherapy for the treatment of bladder cancer. The primary purpose of this study is to investigate the safety and immune-stimulating properties of a novel therapy being developed at NCSU. Testing Requirements 8-day study (Monday –…

Jul 18, 2023

Now Enrolling Canine Patients with Liver Tumors

Principle Investigator Dr. Mike Sano Description Does your dog have a liver tumor? We are now enrolling canine patients that have a liver tumor into a clinical trial that is using a new therapy called INSPIRE, which uses electrical pulses to safely destroy the cells within a tumor. This study has two treatment groups. One…

Jan 31, 2023

Screening urine samples from high-risk dog breeds for early bladder cancer – NOT CURRENTLY RECRUITING

Principal Investigator Dr Shelly Vaden Description This study is screening urine samples from clinically healthy dogs at increased risk of bladder cancer, to determine if they test positive for a genetic marker of the disease (a specific mutation in the dog BRAF gene). The goal is to determine whether this BRAF Mutation Detection test can…

Jan 31, 2023

Therapeutic trials for canine bladder cancer (NOT CURRENTLY RECRUITING)

Principal Investigator Dr Shelly Vaden Description This study will investigate whether the administration of a dietary supplement slows the progression of canine bladder cancer (also known as transitional cell carcinoma/urothelial carcinoma, or TCC/UC) in dogs treated with standard of care therapy Testing Requirements Participants will be asked to: – bring their dog for an initial…

Jan 19, 2023

Now Enrolling Dogs with Bladder Cancer

Principal Investigator Dr. Michael Mastromauro Description NC State University College of Veterinary Medicine is enrolling in a clinical trial to investigate if a probiotic can improve cancer care and outcomes in dogs with bladder cancer. This is a placebo-controlled study, not all dogs will receive the probiotic, but all dogs will receivechemotherapy (vinblastine/piroxicam). Testing Requirements…

Aug 3, 2022

INSPIRE THERAPY FOR CANINE MAMMARY CARCINOMA

Principal Investigator Dr. Mike Sano Description This study is looking for dogs with 1-2 discrete mammary tumors measuring between 1-3cm to participate in a clinical trial that is investigating a new therapy called INSPIRE, which uses electrical pulses to safely destroy the membranes of cells within a tumor. Owners will need to bring their dog…

Aug 3, 2022

Investigating the Efficacy of a Dietary Supplement in Delaying the Progression of Canine Urothelial Carcinoma/Bladder Cancer 

Principal Investigator Dr Shelly Vaden Description This study will investigate: 1. whether urine-based screening for a genetic marker (a specific mutation in the BRAF gene) can detect canine urothelial carcinoma/bladder cancer before the onset of clinical signs. 2. whether a dietary supplement delays the onset of clinical signs in dogs that have a detectable urinary…