Dr. Mark G. Papich is a Professor of Clinical Pharmacology and the Burroughs Wellcome Fund Professorship in Veterinary Pharmacology at North Carolina State University. He is the Supervisor of the Clinical Pharmacology Laboratory in the College of Veterinary Medicine at North Carolina State University. He is a diplomate in the American College of Veterinary Clinical Pharmacology (ACVCP), and has served as president of ACVCP. He is also a Fellow in the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT). He has served on various Expert Committees: the Council of Experts, and Chairman for the Veterinary Drugs Expert Committee for the United States Pharmacopeia (USP), and the USP Expert Committee on Antibiotics. He is a member and past Chairholder of the Clinical Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing subcommittee (VAST) and on the Expert Panel on Microbiology for CLSI. He served as a member of the Veterinary Medicine Advisory Committee of the Food and Drug Administration (FDA). He has taught veterinary pharmacology for over 25 years.
He has authored/edited eight books on veterinary pharmacology and is one of the editors of the 9th and 10th editions of Veterinary Pharmacology and Therapeutics. He is author or co-author of over 235 research papers published in refereed journals and has authored over 130 book chapters, and review papers. He has several awards including the Zoetis Distinguished Veterinary Teacher Award and the Faculty Award presented to the outstanding teacher by veterinary classes. He was also awarded the Pfizer Award for Research Excellence, the Excellence in Consensus Management by the Clinical and Laboratory Standards Institute (CLSI), the Lloyd E. Davis Award by the AAVPT, and the Huffman Leadership Award from NC State University. He has also delivered hundreds of presentations on veterinary pharmacology at national and international veterinary meetings, conferences and symposia.
Member of the AVMA, AAVPT, and ACVCP. Voting member of the CLSI Veterinary Antimicrobial Susceptibility Testing subcommittee, Member of the USP Expert Committee on Antibiotics and Expert Panel on Veterinary Drug Formulations.
Diplomate American College of Veterinary Clinical Pharmacology (ACVCP)
Area(s) of Expertise
COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, PHARMACOLOGY
The research program in veterinary clinical pharmacology at North Carolina State University College of Veterinary Medicine consists of studies designed to define and improve rational drug therapy in animals. The research emphasis includes studies in a wide variety of animal species, including dogs, cats, horses, ruminants, zoo animals, reptiles, fish, and birds. Current studies focus on the disposition of antibiotics, antifungal drugs, anti-inflammatory drugs, gastrointestinal drugs, and analgesic drugs in a variety of animal species. We also have studies on-going to investigate treatment of opioid overdose using animal models. Studies originate from our laboratory, or are performed in collaboration with clinical faculty at NCSU, and investigators at other veterinary colleges, zoos, or pharmaceutical companies. The Clinical Pharmacology Laboratory is equipped with state-of-the-art analytical equipment and has procedures for analyzing most medications administered to animals. The Laboratory maintains software licenses for current pharmacokinetic software capable of performing traditional compartmental modeling, non-compartmental pharmacokinetics, pharmacokinetic-pharmacodynamic (PK-PD) analysis, and nonlinear mixed-effects modeling (NLME) for population studies.
- Pharmacokinetics of a FDA-labeled dose of diclazuril administered orally once weekly to adult horses , JOURNAL OF EQUINE VETERINARY SCIENCE (2023)
- Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump , JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE (2022)
- Effects of housing environment on oral absorption of acetaminophen in healthy Beagles , AMERICAN JOURNAL OF VETERINARY RESEARCH (2022)
- Gastrointestinal transit time is faster in Beagle dogs compared to cats , JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2022)
- Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics , ADMET AND DMPK (2022)
- PHARMACOKINETICS OF A SINGLE DOSE OF INTRAMUSCULAR AND ORAL MELOXICAM IN YELLOW STINGRAYS (UROBATIS JAMAICENSIS) , JOURNAL OF ZOO AND WILDLIFE MEDICINE (2022)
- Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine , Journal of the American Veterinary Medical Association (2022)
- Veterinary antimicrobial prescribing practices for treatment of presumptive sporadic urinary tract infections in dogs examined at primary care practices in the United States (2010-2019) , JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2022)
- Ampicillin pharmacokinetics in azotemic and healthy dogs , JOURNAL OF VETERINARY INTERNAL MEDICINE (2021)
- Antimicrobial agent use in small animals what are the prescribing practices, use of PK‐PD principles, and extralabel use in the United States? , Journal of Veterinary Pharmacology and Therapeutics (2021)
- Research Area of Emphasis: Computational Biology and Bioinformatics
- CVM: Feline Health
- CVM: Focus Area
- Focus Area: Graduate Pharmacology
- Molecular Biomedical Sciences: MBS Faculty
- Molecular Biomedical Sciences: MBS Pharmacology
- Molecular Biomedical Sciences: MBS Researchers
- CVM: Molecular Biomedical Sciences
- Research Area of Emphasis: Pharmacology
- CVM: Research Area of Emphasis