Dr. Mark G. Papich is a Professor of Clinical Pharmacology and the Burroughs Wellcome Fund Professorship in Veterinary Pharmacology at North Carolina State University. He is the Supervisor of the Clinical Pharmacology Laboratory in the College of Veterinary Medicine at North Carolina State University. He is a diplomate in the American College of Veterinary Clinical Pharmacology (ACVCP), and has served as president of ACVCP. He has served on various Expert Committees: the Council of Experts, and Chairman for the Veterinary Drugs Expert Committee for the United States Pharmacopeia (USP), and is a current member of the USP Expert Committee on Antibiotics. He is a member of the AVMA Committee on Antibiotics (CoA). He is a member and past Chairholder of the Clinical Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing subcommittee (VAST) and chair of CLSI working groups. He served as a member of the Veterinary Medicine Advisory Committee of the Food and Drug Administration (FDA). He has taught veterinary pharmacology for over 30 years.
He has authored/edited eight books on veterinary pharmacology and is one of the editors of the 9th and 10th editions of Veterinary Pharmacology and Therapeutics. He is author or co-author of over 275 research papers published in refereed journals and has authored over 135 book chapters, and review papers (h-index 56). He has several awards including the Zoetis Distinguished Veterinary Teacher Award and the Faculty Award presented to the outstanding teacher by veterinary classes. He was also awarded the Pfizer Award for Research Excellence, the Excellence in Consensus Management by the Clinical and Laboratory Standards Institute (CLSI), the Lloyd E. Davis Award by the AAVPT, the Distinguished Fellow Award from AAVPT, and the Huffman Leadership Award from NC State University. He has also delivered hundreds of presentations on veterinary pharmacology at national and international veterinary meetings, conferences and symposia.
American Veterinary Medical Association (AVMA), American Academy of Veterinary Pharmacology and Therapeutics (AAVPT, Distinguished Fellow), American College of Veterinary Clinical Pharmacology (ACVCP), United States Pharmacopeia (USP), and Clinical and Laboratory Standards Institute (CLSI).
American College of Veterinary Clinical Pharmacology (ACVCP)
Area(s) of Expertise
COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, PHARMACOLOGY
The research program in veterinary clinical pharmacology at North Carolina State University College of Veterinary Medicine consists of studies designed to define and improve rational drug therapy in animals. The research emphasis includes studies in a wide variety of animal species, including dogs, cats, horses, ruminants, zoo animals, reptiles, fish, and birds. Current studies focus on the disposition of antibiotics, antifungal drugs, anti-inflammatory drugs, gastrointestinal drugs, and analgesic drugs in a variety of animal species. We also have studies on-going to investigate treatment of opioid overdose using animal models. Studies originate from our laboratory, or are performed in collaboration with clinical faculty at NCSU, and investigators at other veterinary colleges, zoos, or pharmaceutical companies. The Clinical Pharmacology Laboratory is equipped with state-of-the-art analytical equipment and has procedures for analyzing most medications administered to animals. The Laboratory maintains software licenses for current pharmacokinetic software capable of performing traditional compartmental modeling, non-compartmental pharmacokinetics, pharmacokinetic-pharmacodynamic (PK-PD) analysis, and nonlinear mixed-effects modeling (NLME) for population studies.
- The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses , JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2024)
- Antimicrobial agents in small animal dermatology for treating staphylococcal infections , JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2023)
- Effects of storage up to 1 year on the in vitro antimicrobial activity of preformulated antibiotic-impregnated calcium sulfate beads , VETERINARY SURGERY (2023)
- Pharmacokinetics of a FDA-labeled dose of diclazuril administered orally once weekly to adult horses , JOURNAL OF EQUINE VETERINARY SCIENCE (2023)
- Pharmacokinetics of pimobendan after oral administration to dogs with myxomatous mitral valve disease , JOURNAL OF VETERINARY INTERNAL MEDICINE (2023)
- Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function , JOURNAL OF VETERINARY INTERNAL MEDICINE (2023)
- Population pharmacokinetics of single dose oral pimobendan in the ferret (Mustela putorius furo) , JOURNAL OF EXOTIC PET MEDICINE (2023)
- Revision of fluoroquinolone breakpoints used for interpretation of antimicrobial susceptibility testing of canine bacterial isolates , AMERICAN JOURNAL OF VETERINARY RESEARCH (2023)
- THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ORAL PONAZURIL IN THE TREATMENT OF SYSTEMIC ISOSPOROSIS IN PASSERINE BIRDS , JOURNAL OF ZOO AND WILDLIFE MEDICINE (2023)
- Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump , JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE (2022)
- Research Area of Emphasis: Computational Biology and Bioinformatics
- CVM: Feline Health
- CVM: Focus Area
- Focus Area: Graduate Pharmacology
- Molecular Biomedical Sciences: MBS Faculty
- Molecular Biomedical Sciences: MBS Pharmacology
- Molecular Biomedical Sciences: MBS Researchers
- CVM: Molecular Biomedical Sciences
- Research Area of Emphasis: Pharmacology
- CVM: Research Area of Emphasis