Dr. Kaeser studied biology at the Eberhard Karls University Tübingen (Germany) with a focus on molecular biology, virology and microbiology. He became interested in immunology; so he decided to pursue his Diploma thesis and subsequent PhD thesis at an immunological institute.
In 2004, Dr. Kaeser joined one of the best swine immunology laboratories worldwide – the Institute of Immunology of Prof. Armin Saalmüller at the Vetmeduni Vienna. His research emphasis was the analysis of the porcine cellular immune response with a focus on CD4+ cells – T-helper and regulatory T cells. He also strongly promoted flow cytometry by his active participation in the Austrian Society for Cytometry and his work on the production of fluorescence-conjugated antibodies for pigs. This work facilitated multi-color flow cytometry for swine: for the first time, a comprehensive phenotypical and functional analysis of the porcine cellular immune response became available.
In 2013, Dr. Kaeser joined the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) in Saskatoon, Canada, to use this technology for biomedical research. Under the supervision of Dr. François Meurens and Volker Gerdts, he successfully established the pig as a model to study genital genital chlamydia infections – both, the porcine pathogen Chlamydia suis (Cs) and the human pathogen Chlamydia trachomatis (Ct).
In 2016, Dr. Kaeser joined NC State as an Assistant Professor in Swine Immunology at the College of Veterinary Medicine and the department of Population Health and Pathobiology. Dr. Kaeser uses his expertise in studying the adaptive immune response and the development of immunological memory in pigs not only to promote animal health but also to use swine as a biomedical animal model for food allergy (eosinophilic esophagitis, EoE) and Ct.
The animal health component of Dr. Kaeser’s research is focused on studying heterologous immunity to various strains of the most important transmittable pig disease – the porcine reproductive and respiratory syndrome virus (PRRSV). Dr. Kaeser collaborates with a strong group of swine researchers to limit the impact of PRRSV on the NC, US, and world-wide swine industry – Drs. Glen Almond and Juliana Bonin-Ferreira (swine health and production), Elisa Crisci (swine virology), Gustavo Machado (epidemiology), Tatiane Watanabe (pathology), and Monique Pairis-Garcia (animal welfare).
Dr. Kaeser is also well-integrated into the research community of the Research Triangle including the University of North Carolina (UNC): he uses this network of renown experts in the field to drive interdisciplinary research for both biomedical projects – EoE and Ct. Together with EoE experts (e.g. Evan Dellon, UNC), swine gastrointestinal experts (Anthony Blikslager and Liara Gonzalez), nutrition experts (Jack Odle) and other immunologists (Scott Laster), he uses the pig for studying EoE including the development of pre- and intervention strategies. For the Ct project, Dr. Kaeser collaborates with international Ct experts like Toni Darville (UNC) and Kenneth Beagley (Queensland University of Technology, Australia) and vaccine development experts like Volker Gerdts (VIDO-InterVac, Canada). This collaborations aims to use a unique model of Cs-pre-exposed outbred pigs to develop vaccines against Ct.
The main biomedical research goal of Dr. Kaeser is to promote the swine model for biomedical research and to use collaborations for the development and testing of pre- and intervention strategies against transmittable and non-transmittable human diseases.
– American Association of Veterinary Immunologists (AAVI)
– Edward Jenner Vaccine Society
– German Society of Immunology (DGfI)
– Austrian Society for Cytometry (ÖGfZ)
– Chlamydia Basic Research Society
– Conference of Research Workers in Animal Diseases (CRWAD)
In addition, am a member of the “Young Investigator Program class of 2015” from the journal “Vaccine” (https://www.journals.elsevier.com/vaccine/tobias-kaser/) and acted as a guest editor for their special issue on the World Vaccine Congress 2016.
Area(s) of Expertise
IMMUNOLOGY, INFECTIOUS DISEASES
The overall goal of my lab is to study memory immune responses in pigs to facilitate the development of vaccines and intervention strategies for porcine and human diseases. My lab currently consists of one lab manager and two PhD students, representing the three research foci of my lab: i) We study the porcine adaptive immune response to heterologous PRRSV strains to evaluate the capacity of vaccines to provide cross-protection. ii) and iii), we use the pig as a model to study human food allergy and Chlamydia trachomatis infections.
We use in vivo trials in combination with in vitro re-stimulation assays to study pathogen load, the production of neutralizing antibodies, and the induction and function of memory immune cells using qPCR, fluorescent microscopy, and up to 9-color flow cytometry.
- Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(-/-)IL2RG(y/-) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation , FRONTIERS IN VETERINARY SCIENCE (2022)
- Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine , FRONTIERS IN MICROBIOLOGY (2022)
- Host-Pathogen Interactions of Chlamydia trachomatis in Porcine Oviduct Epithelial Cells , PATHOGENS (2021)
- Maternal Autogenous Inactivated Virus Vaccination Boosts Immunity to PRRSV in Piglets , VACCINES (2021)
- Swine as biomedical animal model for T-cell research-Success and potential for transmittable and non-transmittable human diseases , MOLECULAR IMMUNOLOGY (2021)
- Maternal Autogenous Inactivated Virus Vaccination Boosts the Piglet Humoral and Cell-Mediated Immunity to PRRSV via Transfer of Neutralizing Antibodies and Interferon-Gamma Producing B Cells , (2020)
- Mucosal Vaccination with UV-Inactivated Chlamydia suis in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ+ Effector Memory Cells , Vaccines (2020)
- Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine gamma delta T Cells , FRONTIERS IN IMMUNOLOGY (2019)
- The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) , Viruses (2019)
- Contribution of the swine model in the study of human sexually transmitted infections , Infection, Genetics and Evolution (2018)
- CVM: Focus Area
- Focus Area: Food Animal
- Focus Area: Graduate Infectious Diseases
- Focus Area: Graduate Population Medicine
- Research Area of Emphasis: Immunology
- Focus Area: Immunology
- Research Area of Emphasis: Infectious Diseases
- Population Health and Pathobiology: PHP Faculty
- Population Health and Pathobiology: PHP Swine Health
- CVM: Population Health and Pathobiology
- CVM: Research Area of Emphasis