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Ed Breitschwerdt, DVM, DACVIM

Professor, Internal Medicine

Contact:

ed_breitschwerdt@ncsu.edu
Office: 919.513.8277
Lab: Vector Borne Disease Diagnostics
Lab Phone: 919.513.8279

Dr. Edward B. Breitschwerdt is a professor of medicine and infectious diseases at North Carolina State University College of Veterinary Medicine. He is also an adjunct professor of medicine at Duke University Medical Center, and a Diplomate, American College of Veterinary Internal Medicine (ACVIM). Dr. Breitschwerdt directs the Intracellular Pathogens Research Laboratory in the Institute for Comparative Medicine at North Carolina State University. He also co-directs the Vector Borne Diseases Diagnostic Laboratory and is the director of the NCSU-CVM Biosafety Level 3 Laboratory.

A graduate of the University of Georgia, Breitschwerdt completed an internship and residency in Internal Medicine at the University of Missouri between 1974 and 1977. He has served as president of the Specialty of Internal Medicine and as chairman of the ACVIM Board of Regents. He is a former associate editor for the Journal of Veterinary Internal Medicine and was a founding member of the ACVIM Foundation.

Breitschwerdt’s clinical interests include infectious diseases, immunology, and nephrology. For over 30 years, his research has emphasized vector-transmitted, intracellular pathogens. Most recently, he has contributed to cutting-edge research in the areas of animal and human bartonellosis. In addition to authoring numerous book chapters and proceedings, Dr. Breitschwerdt’s research group has published more that 350 manuscripts in peer-reviewed scientific journals. In 2012, he received the North Carolina State University Alumni Association Outstanding Research Award and in 2013 he received the Holladay Medal, the highest award bestowed on a faculty member at North Carolina State University.
Certifications
Diplomate, American College of Veterinary Internal Medicine
Infectious Diseases
Dr. Breitschwerdt's research emphasis has been on vector-transmitted, intracellular pathogens. Since 1984, he has supervised a biosafety level P-3 research laboratory and co-supervised the Tick-transmitted Diagnostic Laboratory.

  • Molecular mechansims of Bartonella resistance to azithromycin, enrofloxacin and pradofloxacin.Biswas S, RG Maggi, MG Papich, EB Breitschwerdt: | J Antimicrob Chemother 65:581-582; 2010.
  • Bartonella vinsonii subsp. berkhoffii and Bartonella henselae in a father and daughter with neurological disease.Breitschwerdt EB, RG Maggi, PM Lantos, CW Woods, BC Hegarty, JM Bradley: | Parasites & Vectors 3: 29; 2010.
  • Isolation or PCR amplification of Bartonella koehlerae from human blood.Breitschwerdt EB, RG Maggi, BR Mozayeni, JM Bradley, BC Hegarty, PE Mascarelli: | Parasites & Vectors 3: 76; 2010.
  • Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and B. henselae to a child.Breitschwerdt EB, RG Maggi, P Farmer, PE Mascarelli: | J Clin Microbiol 48: 2289-2293, 2010.
  • Putative needle stick transmission of Bartonella vinsonii subsp. berkhoffii to a veterinarian.Oliveira AM, RG Maggi, CW Woods, EB Breitschwerdt: | J Vet Intern Med 24: 1229-1232; 2010.
  • Rickettsia rickettsii transmission by a lonestar tick, North Carolina.Breitschwerdt EB, BC Hegarty, RG Maggi, PM Lantos, DM Aslett, JM Bradley: | 2011 May [Epub ahead of print]
  • Bartonella spp. bacteremia in patients with neurological and neuro-cognitive dysfunction.Breitschwerdt EB, RG Maggi, WL Nicholson, NA Cherry, CW Woods: | J Clin Microbiol 46:2856-2861; 2008.
  • Detection of Bartonella henselae in the blood of two adult horses.Jones SL, RG Maggi, J Shuler, A Alward, EB Breitschwerdt: | J Vet Intern Med 22:495-498; 2008.
  • Use of broad range 16S rDNA PCR in clinical microbiology.Sontakke S, MB Cadenas, RG Maggi, PPVP Diniz, EB Breitschwerdt: | J Microbiol Meth 76:217-225; 2009.
  • Comparative medical features of canine and human bartonellosis.Breitschwerdt EB, RG Maggi. | Clin Microbiol Infect 15(Suppl.1):1-2; 2009.
  • Isolation of Bartonella vinsonii subsp berkhoffii genotype II from a boy with epitheloid hemangioendothelioma and a dog with hemangiopericytoma.Breitschwerdt EB, RG Maggi, M Varanat, KE Linder, G Weinberg: | J Clin Microbiol 47:1957-1960; 2009.
  • A confusing case of canine vector-bonre disease: clinical signs and progression in a dog co-infected with Ehrlichia canis and Bartonella vinsonii subsp. berkhoffii.Breitschwerdt EB, RG Maggi: | Parasitol and Vectors 26(Suppl 1):S3; 2009.
  • A ground hog, a novel Bartonella sequence and my father’s death.Breitschwerdt EB, RG Maggi, MB Cadenas, PPVP Diniz: | Emerg Infect Dis 15:2080-2086; 2009.
  • Comparative activity of pradofloxacin, enrofloxacin and azithromycin against Bartonella henselae isolates derived from cats and a human.Biswas S, RG Maggi, MG Papich, D Keil, EB Breitschwerdt: | J Clin Microbiol 48:617-618; 2010.
  • 2013. Extrauterine listeriosis in the gravid mouse influences embryonic growth and development. Suyemoto, M.M., Hamrick, T.S., Spears, P.A., Horton, J.A., Washington, I.D., Havell, E.A., Borst, L.A., and Orndorff, P.E. | PLoS 0ne 8(8):e72601.
  • 2011. In vitro properties of a Listeria monocytogenes bacteriophage resistant mutant predict its efficacy as a live oral vaccine strain.Spears, P.A., Suyemoto, M.M., Hamrick, T.S., Wolf, R., Havell, E.A., and Orndorff, P.E.  | Infect. Immun. 79:5001-5009.
  • Orndorff PE.Suyemoto MM, Spears PA, Hamrick TS, Barnes JA, Havell EA | PLoS One. 2010 Sep 27;5(9):e13000. doi: 10.1371/journal.pone.0013000.
  • Isolation of Bartonella vinsonii subsp berkhoffii genotype II from a boy with epitheloid hemangioendothelioma and a dog with hemangiopericytoma.Breitschwerdt EB, RG Maggi, M Varanat, KE Linder, G Weinberg: | J Clin Microbiol 47:1957-1960; 2009.
  • A confusing case of canine vector-bonre disease: clinical signs and progression in a dog co-infected with Ehrlichia canis and Bartonella vinsonii subsp. berkhoffii.Breitschwerdt EB, RG Maggi: | Parasitol and Vectors 26(Suppl 1):S3; 2009.
  • Comparative activity of pradofloxacin, enrofloxacin and azithromycin against Bartonella henselae isolates derived from cats and a human.Biswas S, RG Maggi, MG Papich, D Keil, EB Breitschwerdt: | J Clin Microbiol 48:617-618; 2010.
  • Molecular mechansims of Bartonella resistance to azithromycin, enrofloxacin and pradofloxacin.Biswas S, RG Maggi, MG Papich, EB Breitschwerdt: | J Antimicrob Chemother 65:581-582; 2010.
  • Bartonella vinsonii subsp. berkhoffii and Bartonella henselae in a father and daughter with neurological disease.Breitschwerdt EB, RG Maggi, PM Lantos, CW Woods, BC Hegarty, JM Bradley: | Parasites & Vectors 3: 29; 2010.
  • Isolation or PCR amplification of Bartonella koehlerae from human blood.Breitschwerdt EB, RG Maggi, BR Mozayeni, JM Bradley, BC Hegarty, PE Mascarelli: | Parasites & Vectors 3: 76; 2010.
  • Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and B. henselae to a child.Breitschwerdt EB, RG Maggi, P Farmer, PE Mascarelli: | J Clin Microbiol 48: 2289-2293, 2010.
  • Putative needle stick transmission of Bartonella vinsonii subsp. berkhoffii to a veterinarian.Oliveira AM, RG Maggi, CW Woods, EB Breitschwerdt: | J Vet Intern Med 24: 1229-1232; 2010.
  • Rickettsia rickettsii transmission by a lonestar tick, North Carolina.Breitschwerdt EB, BC Hegarty, RG Maggi, PM Lantos, DM Aslett, JM Bradley: | 2011 May [Epub ahead of print]
  • Bartonella spp. bacteremia in patients with neurological and neuro-cognitive dysfunction.Breitschwerdt EB, RG Maggi, WL Nicholson, NA Cherry, CW Woods: | J Clin Microbiol 46:2856-2861; 2008.
  • Detection of Bartonella henselae in the blood of two adult horses.Jones SL, RG Maggi, J Shuler, A Alward, EB Breitschwerdt: | J Vet Intern Med 22:495-498; 2008.
  • Use of broad range 16S rDNA PCR in clinical microbiology.Sontakke S, MB Cadenas, RG Maggi, PPVP Diniz, EB Breitschwerdt: | J Microbiol Meth 76:217-225; 2009.
  • Comparative medical features of canine and human bartonellosis.Breitschwerdt EB, RG Maggi. | Clin Microbiol Infect 15(Suppl.1):1-2; 2009.
  • 2011. In vitro properties of a Listeria monocytogenes bacteriophage resistant mutant predict its efficacy as a live oral vaccine strain. | Infect. Immun. 79:5001-5009.
  • Orndorff PE. | PLoS One. 2010 Sep 27;5(9):e13000. doi: 10.1371/journal.pone.0013000.
  • (2015) Relationship between degenerative joint disease, pain and Bartonella spp. seroreactivity in domesticated cats.Tomas A, Pultorak EL, Gruen ME, Breitschwerdt EB, Lascelles BDX. | Journal of Veterinary Internal Medicine. 2015 Jan;29(1):21-7. doi: 10.1111/jvim.12495. Epub 2014 Oct 18. PMID: 25327962
  • (2014) Bartonella henselae and Bartonella koehlerae DNA in birds9. Mascarelli PE, McQuillan M, Harms CA, Harms RV, Breitschwerdt EB. | Emerg Infec Dis 20: 490-492. http://dx.doi.org/10.3201/eid2003.130563
  • (2011) Assessment of urine solute and matrix effects on the performance of an enzyme-linked immunosorbent assay for measurement of interleukin-6 in dog urine.Wood MW, Nordone SK, Vaden SL, Breitschwerdt EB. | J Vet Diagn Invest, 2011, 23:316-320.
  • (2008) Bartonella species detection in captive, stranded and free-ranging cetaceans.Harms CA, Maggi RG, Breitschwerdt EB, Clemons-Chevis CL, Solangi M, Rotstein DS, Fair PA, Hansen LJ, Hohn AA, Lovewell GN, McLellan WA, Pabst DA, Rowles TK, Schwacke LH, Townsend FI, Wells RS. | Vet Res 39:59:00
  • (2008) Concurrent Hepatic Copper Toxicosis and Fanconi’s Syndrome in a Dog.Hill T, Breitschwerdt E, Cecere T, Vaden S. | J Vet Intern Med, 2008, 22:219-222.
  • (2004) The clinician investigator program in companion animal internal medicine at North Carolina State University.Bunch SE, Ford RB, Hawkins EC, Jackson MW, Vaden SL, Breitschwerdt EB. | J Vet Med Education, 2004; 31:423-432
  • (2001) Infection of fetal feline brain cells in culture with Bartonella henselae.Muñana KR, Vitek SM, Hegarty BC, Kordick DL, Breitschwerdt EB. | Infection and Immunity 2001;69:564-569.
  • (1997) A retrospective case-control study of acute renal failure in 99 dogs.Vaden SL, Levine JF, Breitschwerdt EB. | J Vet Intern Med. 1997; 11:58-64.
  • (1995) The effects of cyclosporine versus standard care in dogs with naturally occurring glomerulonephritis.Vaden SL, Breitschwerdt EB, Armstrong PJ, Correa MT, Brown C, Polzin DJ, Brace JJ, DiBartola SP, Barsanti JA, Crowell W, Jans H, Dimski DS, Bartges J. | J Vet Intern Med 1995; 9:259-266.
  • (1991) Primary ciliary dyskinesia in Bichon frise littermates.Vaden SL, Breitschwerdt EB, Henrickson CK, Metcalf MR, Cohn L, Craig WA. | J Am Anim Hosp Assoc 1991, 27:633-640.