Now Enrolling Dogs with Early Stage Oral Malignant Melanoma
Principle Investigator
Description
NC State University Veterinary Hospital is looking for dogs with stage I or II with oral melanoma for a clinical trial using a new therapeutic drug (GM-1111) and standard-of-care radiotherapy.
The purpose of this clinical trial is to evaluate whether the novel therapy has:
1. Direct anti-cancer activity,
2. Capacity to enhance the effectiveness of radiation therapy in the tumor, and
3. Ability to protect against side effects of radiation therapy.
The clinical trial will also collect safety data.
Testing Requirements
– Radiation therapy: Given as four-once weekly treatments. This treatment is intended to reduce pain and shrink the tumor. Although unlikely, the treatment may cause irritation of the skin, that looks and feels like a sunburn – we can give medicine to help with that, if needed. Similar irritation could affect the lining of the mouth and throat.
– GM-1111: Owners will give an injection under the skin, once daily for 6 weeks.
Enrollment Start
01/26/2024
Enrollment Finish
01/31/2025
Eligibility
• Weigh more than 3 kilograms (6.6 pounds).
• Histopathologic diagnosis of oral malignant melanoma.
• MUST have an oral tumor (< 4 cm diameter) present at enrollment.
• No metastatic disease.
Flyer
Contact
Ashley Fuhrer: 919-515-3634 or cvmclinicalstudies@ncsu.edu
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